HLA-C Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-17922
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | HLA-JY3,D6S204,HLAC,Psoriasis Susceptibility 1,HLA-C Alpha Chain,PSORS1,MHC,HLA-C抗体 |
| Swissprot | P10321 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Synthetic peptide of human HLA-C |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:25-1:100 |
| Concentration | 0.66mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Membrane, MHC I |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described . |
客户发表文献
- 文献: Functional HLA-C expressing trophoblast spheroids as a model to study placental–maternal immune interactions during human implantation
样品类型: Early pregnancy trophoblast tissue,Sw71 cell
