HLA-DRA Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-17927
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | DR alpha chain,DR alpha chain precursor,DRA,DRB1,DRB4,Histocompatibility antigen HLA DR alpha,HLA class II histocompatibility antigen,HLA class II histocompatibility antigen DR alpha chain,HLA DR1B,HLA DR3B,HLA DRA,HLA DRA1,HLA DRB1,HLA DRB3,HLA DRB4,HLA DRB5,HLA-DRA,HLADR4B,HLADRA1,HLADRB,Major histocompatibility complex class II DR alpha,Major histocompatibility complex class II DR beta 1,Major histocompatibility complex class II DR beta 3,Major histocompatibility complex class II DR beta 4,Major histocompatibility complex class II DR beta 5,MGC117330,MHC cell surface glycoprotein,MHC class II antigen DRA,MHC II,MLRW,HLA-DRA抗体 |
| Swissprot | P01903 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Synthetic peptide of human HLA-DRA |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:100 |
| Concentration | 0.9mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cell membrane. Endoplasmic reticulum membrane. Golgi apparatus>trans-Golgi network membrane. Endosome membrane. Lysosome membrane. Late endosome membrane. The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. |
