HP Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-14133
宿主: Rabbit
反应性: H,M,R
应用: WB,IHC
Overview
| Synonyms | Binding peptide,BP,Haptoglobin alpha chain,Haptoglobin alpha(1S) beta,Haptoglobin alpha(2FS) beta,Haptoglobin beta chain,Haptoglobin,alpha polypeptide,Haptoglobin,beta polypeptide,HP,HP2 ALPHA2,HP2ALPHA2,HPA1S,HPT,HPT,MGC111141,Zonulin,HP抗体 |
| Swissprot | P00738 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein of human HP |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:200-1:1000; |
| Concentration | 0.4 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Secreted. |
| Tissue specificity | Expressed by the liver and secreted in plasma. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. |
Images
Western Blot analysis of Human brain gliomas tissue using HP Polyclonal Antibody at dilution of 1:400
Immunohistochemistry of paraffin-embedded Human lung cancer using HP Polyclonal Antibody at dilution of 1:25
Immunohistochemistry of paraffin-embedded Human tonsil using HP Polyclonal Antibody at dilution of 1:25
