HRAS Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-53241
宿主: Rabbit
反应性: H,M,R
应用: WB,IHC
Overview
| Synonyms | C BAS/HAS,c H ras,C HA RAS1,c has/bas p21 protein,c ras Ki 2 activated oncogene,c-H-ras,CTLO,GTP and GDP binding peptide B,GTPase HRas,N-terminally processed,H Ras 1,H RASIDX,H-Ras-1,Ha Ras,Ha Ras1 proto oncoprotein,Ha-Ras,HAMSV,Harvey rat sarcoma viral oncogene homolog,Harvey rat sarcoma viral oncoprotein,HRAS,HRAS1,K ras,N ras,p19 H RasIDX protein,p21ras,Ras family small GTP binding protein H Ras,RASH,RASH1,Transformation gene oncogene HAMSV,Transforming protein p21,v Ha ras Harvey rat sarcoma viral oncogene homolog,VH Ras,vHa RAS,HRAS抗体 |
| Swissprot | P01112 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic peptide of human HRAS |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:25-1:50; |
| Concentration | 0.66mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cell membrane. Golgi apparatus membrane. The active GTP-bound form is localized most strongly to membranes than the inactive GDP-bound form (By similarity). Shuttles between the plasma membrane and the Golgi apparatus. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. |
