HSPB1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-19503
宿主: Rabbit
反应性: H
应用: WB,IHC
Overview
| Synonyms | Heat shock 27kDa protein,28 kDa heat shock protein,CMT2F,DKFZp586P1322,epididymis secretory protein Li 102,Estrogen regulated 24 kDa protein,Estrogen-regulated 24 kDa protein,Heat shock 25kDa protein 1,Heat shock 27 kDa protein,Heat shock 27kD protein 1,Heat shock 27kDa protein 1,Heat shock 28kDa protein 1,Heat Shock Protein 27,Heat shock protein beta 1,Heat shock protein beta-1,heat shock protein family B (small) member 1,HEL-S-102,HMN2B,HS.76067,Hsp 25,HSP 27,Hsp 28,Hsp B1,Hsp25,HSP27,Hsp28,HspB1,HSPB1,SRP27,Stress responsive protein 27,Stress-responsive protein 27,HSPB1抗体 |
| Swissprot | P04792 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Synthetic peptide of human HSPB1 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:25-1:100; |
| Concentration | 0.5mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Nucleus. Cytoplasm>cytoskeleton>spindle. Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. |
Images
Western blot analysis of 293T cell lysates using HSPB1 Polyclonal Antibody at dilution of 1:250
Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using HSPB1 Polyclonal Antibody at dilution of 1:25(×200)
Immunohistochemistry of paraffin-embedded Human gastric cancer tissue using HSPB1 Polyclonal Antibody at dilution of 1:25(×200)
