IGF2BP3 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-19509
宿主: Rabbit
反应性: H
应用: WB,IHC
Overview
| Synonyms | Cancer/testis antigen 98,CT98,DKFZp686F1078,hKOC,IF2B3,IGF II mRNA binding protein 3,IGF-II mRNA-binding protein 3,IGF2 mRNA binding protein 3,IGF2 mRNA-binding protein 3,IGF2BP3,IMP 3,IMP-3,Insulin like growth factor 2 mRNA binding protein 3,Insulin-like growth factor 2 mRNA-binding protein 3,KH domain containing protein overexpressed in cancer,KH domain-containing protein overexpressed in cancer,KOC 1,KOC1,VICKZ 3,VICKZ family member 3,VICKZ3,IGF2BP3抗体 |
| Swissprot | O00425 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Synthetic peptide of human IGF2BP3 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:25-1:100; |
| Concentration | 0.8mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus. Cytoplasm. Found in lamellipodia of the leading edge, in the perinuclear region, and beneath the plasma membrane. The subcytoplasmic localization is cell specific and regulated by cell contact and growth. Localized at the connecting piece and the tail of the spermatozoa. Colocalized with CD44 mRNA in RNP granules. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. |
Images
Western blot analysis of 293T and Hela cell lysates using IGF2BP3 Polyclonal Antibody at dilution of 1:350
Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using IGF2BP3 Polyclonal Antibody at dilution of 1:30(×200)
Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using IGF2BP3 Polyclonal Antibody at dilution of 1:30(×200)
