IL37 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-18110
宿主: Rabbit
反应性: H
应用: WB,IHC
Overview
| Synonyms | FIL1,FIL1 zeta,FIL1(ZETA),FIL1Z,IL 1 zeta,IL 1F7,IL 1F7b (IL 1H4,IL 1H,IL 1RP1),IL 1H4,IL 1RP1,IL 1X,IL 1X protein,IL-1 zeta,IL-1F7,IL-1H,IL-1H4,IL-1RP1,IL-1X,IL-37,IL1F7 (canonical product IL 1F7b),IL1F7,IL1F7,IL1H4,IL1RP1,Interleukin 1 family member 7,interleukin 1 family,member 7 (zeta),Interleukin 1 homolog 4,Interleukin 1 related protein,Interleukin 1 superfamily z,Interleukin 1 zeta,Interleukin 37,Interleukin-1 family member 7,Interleukin-1 homolog 4,Interleukin-1 zeta,Interleukin-1-related protein,Interleukin-23,IL37抗体 |
| Swissprot | Q9NZH6 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Synthetic peptide of human IL37 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:20-1:100; |
| Concentration | 1.5mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm>cytosol. Nucleus. Secreted. Stimulation with IL1B leads to colocalization with SMAD3 mostly in perinuclear regions. Only the CASP1-cleaved mature form translocates into the nucleus upon LPS stimulation. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. IL37 (Interleukin 37) is a Protein Coding gene. Diseases associated with IL37 include Rheumatoid Arthritis. Among its related pathways are Innate Immune System and Toll-Like receptor Signaling Pathways. GO annotations related to this gene include cytokine activity and interleukin-1 receptor binding. An important paralog of this gene is IL36G. |
