IL4R Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-52020
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | CD124,IL 4R alpha,IL-4 receptor subunit alpha,IL-4-binding protein,IL-4R subunit alpha,IL-4R-alpha,IL-4RA,IL4-BP,Il4r,IL4R nirs variant 1,IL4RA,IL4RA,Interleukin 4 receptor alpha chain,Interleukin 4 receptor,sIL4Ralpha/prot,Soluble IL-4 receptor subunit alpha,Soluble IL-4R-alpha,Soluble interleukin-4 receptor subunit alpha,IL4R抗体 |
| Swissprot | P24394 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Synthetic peptide of human IL4R |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:30-1:150 |
| Concentration | 1.26mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Secreted and Cell membrane. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. |
