IL-17A Polyclonal Antibody
| 规格： | / 25μL / 100μL |
| 价格： | / ￥800 / ￥2100 |
货号：D-AB-10453L
货期：咨询
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | CTLA 8;CTLA-8;CTLA8;Cytotoxic T lymphocyte associated antigen 8;Cytotoxic T lymphocyte associated protein 8;Cytotoxic T lymphocyte associated serine esterase 8;Cytotoxic T-lymphocyte-associated antigen 8;IL 17A;IL-17;IL-17A;IL17;IL17;Il17a;Interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8);Interleukin 17A;Interleukin-17A;Interleukin17;Interleukin17A;OTTHUMP00000016597;OTTMUSP00000046003 |
| Swissprot | Q61453 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Recombinant Rat IL-17A protein expressed by E.coli |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:500-1:1000 |
| Concentration | 1mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Secreted |
| Isotype | IgG |
| Purification | Antigen Affinity Purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,1% BSA and 50% glycerol,pH7.4 |
| Background | IL17A,also named as IL-17,is a proinflammatory cytokine. IL-17,synthesized only by memory T cells and natural killer cells,has pleiotropic effects,mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2),as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis,psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein,that is widely expressed on epithelial cells,fibroblasts,B and T cells,and monocytic cells. In psoriatic skin lesions,both Th17 cells and their downstream effector molecules,e.g. IL-17 and IL-22,are highly increased. |
