INPP5D Polyclonal Antibody
| 规格： | / 60μL / 120μL / 200μL |
| 价格： | / ￥1380 / ￥2220 / ￥3300 |
货号：E-AB-70200
宿主: Rabbit
反应性: M,R
应用: IHC
Overview
| Synonyms | Inositol polyphosphate 5 phosphatase of 145kDa,4,5-trisphosphate 5-phosphatase 1,hp51CN,Inositol polyphosphate 5 phosphatase 145kDa,Inositol polyphosphate 5 phosphatase,Inositol polyphosphate-5-phosphatase of 145 kDa,INPP5D,MGC104855,MGC142140,MGC142142,p150Ship,Phosphatidylinositol 3,4,5 trisphosphate 5 phosphatase 1,Phosphatidylinositol-3,SH2 containing inositol phosphatase isoform b,SH2 domain containing inositol 5' phosphatase 1,SH2 domain containing inositol phosphatase 1,SH2 domain-containing inositol phosphatase 1,SH2 domain-containing inositol-5''-phosphatase 1,SHIP-1,SHIP1,SHIP1,Signaling inositol polyphosphate 5 phosphatase SIP 145,SIP-145,SIP145,INPP5D抗体 |
| Swissprot | Q9ES52,P97573 |
| Source | Rabbit |
| Reactivity | Mouse,Rat |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse SHIP1 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:200-1:1000 |
| Concentration | 430 μg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Membrane. Translocates to the plasma membrane when activated, translocation is probably due to different mechanisms depending on the stimulus and cell type. Partly translocated via its SH2 domain which mediates interaction with tyrosine phosphorylated receptors such as the FC-gamma-RIIB receptor (FCGR2B) or CD16/FCGR3. Tyrosine phosphorylation may also participate to membrane localization. |
| Tissue specificity | Specifically expressed in immune and hematopoietic cells. Levels vary considerably within this compartment. Lost during erythropoiesis when erythroid cells become Ter119+. Increases substantially with T-cell maturation and when resting B-cells are activated. Also present in mature granulocytes, monocyte/macrophages, mast cells and platelets. Isoform 5 is the only form expressed in embryonic stem (ES) cells and is coexpressed with other isoforms in hematopoietic stem cells, and disappears with differentiation.Highest expression level in stroma of bone marrow. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
| Background | This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants. |
