IRGM Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-11336
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | IFI1,Iigp3,Iipg3,Immunity related GTPase family M protein 1,Immunity related GTPase family,M,Immunity-related GTPase family M protein 1,Immunity-related GTPase family M protein,Interferon inducible protein 1,Interferon-inducible protein 1,Irgm,IRGM,IRGM1,LPS-stimulated RAW 264.7 macrophage protein 47 homolog,LRG 47,LRG-47,LRG-47-like protein,LRG47,MGC149263,MGC149264,IRGM抗体 |
| Swissprot | A1A4Y4 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Recombinant protein of human IRGM |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 0.4 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Golgi apparatus membrane. Cell membrane. Cytoplasmic vesicle>phagosome membrane. Cytoplasmic vesicle>autophagosome membrane. Cell projection>phagocytic cup. Behaves like an integral membrane protein (By similarity). Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing autophagosomes (By similarity). Preferentially associated with cis- and medial-Golgi. |
| Tissue specificity | Widely expressed (at protein level). Expressed in several tissues including colon, small bowel and peripheral blood leukocytes. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis. |
