JUN Polyclonal Antibody
| 规格： | / 60μL / 120μL / 200μL |
| 价格： | / ￥1380 / ￥2220 / ￥3300 |
货号：E-AB-70029
宿主: Rabbit
反应性: H,M
应用: IHC
Overview
| Synonyms | Activator protein 1,AP 1,AP1,cJun,Enhancer Binding Protein AP1,Jun Activation Domain Binding Protein,JUN,Jun oncogene,JUN protein,Jun proto oncogene,JUN,JUNC,Oncogene JUN,p39,Proto oncogene c jun,Proto oncogene cJun,Proto-oncogene c-jun,Transcription Factor AP 1,Transcription factor AP-1,Transcription Factor AP1,V jun avian sarcoma virus 17 oncogene homolog,V jun sarcoma virus 17 oncogene homolog (avian),V jun sarcoma virus 17 oncogene homolog,V-jun avian sarcoma virus 17 oncogene homolog,vJun Avian Sarcoma Virus 17 Oncogene Homolog,JUN抗体 |
| Swissprot | P05412,P05627,P17325 |
| Source | Rabbit |
| Reactivity | Human,Mouse |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse c- JUN |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:500-1:2000; |
| Concentration | 1.15 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus |
| Tissue specificity | Highest expression level in amniotic fluid |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
| Background | JUN is also named as c-Jun and AP1,belongs to the bZIP family and Jun subfamily. JUN,the most extensively studied protein of the activator protein-1 (AP-1) complex,is involved in numerous cell activities,such as proliferation,apoptosis,survival,tumorigenesis and tissue morphogenesis. JUN is a transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. It promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. JUN is a basic leucine zipper (bZIP) transcription factor that acts as homo- or heterodimer,binding to DNA and regulating gene transcription. In additon,extracellular signals can induce post-translational modifications of JUN,resulting in altered transcriptional activity and target gene expression. More over,it has uncovered multiple layers of a complex regulatory scheme in which JUN is able to crosstalk,amplify and integrate different signals for tissue development and disease. Jun is predominantly nuclear,ubiquitinated Jun colocalizes with lysosomal proteins. |
Images
Immunohistochemistry analysis of paraffin-embedded human lung cancer using JUN Polyclonal Antibody at dilution of 1:500.
Immunohistochemistry analysis of paraffin-embedded human liver cancer using JUN Polyclonal Antibody at dilution of 1:500.
Immunohistochemistry analysis of paraffin-embedded Mouse spleen using JUN Polyclonal Antibody at dilution of 1:1000.
