KCNA1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-12529
宿主: Rabbit
反应性: H,M,R
应用: WB
Overview
| Synonyms | AEMK,EA1,Episodic ataxia with myokymia,HBK1,HUK1,Kca1 1,Kcna1,KCNA1,Kcpvd,KV1.1,MBK1,mceph,MGC124402,MGC126782,MGC138385,MK1,MK1,mouse,homolog of KV1.1,Potassium channel protein 1,Potassium voltage gated channel shaker related subfamily member 1,Potassium voltage gated channel subfamily A member 1,Potassium voltage gated channel,shaker related subfamily,member 1 (episodic ataxia with myokymia),Potassium voltage-gated channel subfamily A member 1,RBK1,RCK1,Shak,Shaker related subfamily member 1,Voltage gated potassium channel subunit Kv1.1,Voltage-gated K(+) channel HuKI,Voltage-gated potassium channel HBK1,Voltage-gated potassium channel subunit Kv1.1,KCNA1抗体 |
| Swissprot | Q09470 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic peptide of human KCNA1 |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:500-1:2000; |
| Concentration | 0.4 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Membrane. |
| Tissue specificity | Detected adjacent to nodes of Ranvier in juxtaparanodal zones in spinal cord nerve fibers, but also in paranodal regions in some myelinated spinal cord axons (at protein level) (PubMed:11086297). Detected in the islet of Langerhans (PubMed:21483673). |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK). |
