KDM2A Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-17949
宿主: Rabbit
反应性: H,M
应用: IHC
Overview
| Synonyms | [Histone-H3]-lysine-36 demethylase 1A,CXXC-type zinc finger protein 8,CXXC8,F box / LRR repeat protein 11,F box and leucine rich repeat protein 11,F box protein FBL7,F-box and leucine-rich repeat protein 11,F-box protein FBL7,F-box protein Lilina,F-box/LRR-repeat protein 11,FBL11,FBL7,FBXL11,JHDM1A,JmjC domain-containing histone demethylation protein 1A,Jumonji C domain containing histone demethylase 1A ,kdm2a,KDM2A,LILINA,Lysine (K) specific demethylase 2A,Lysine-specific demethylase 2A,KDM2A抗体 |
| Swissprot | Q9Y2K7 |
| Source | Rabbit |
| Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human KDM2A |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:300 |
| Concentration | 1.62mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus>nucleoplasm. Punctate expression throughout the nucleoplasm and enriched in the perinucleolar region. Specifically nucleates at CpG islands where it's presence results in chromatin depleted in H3K36me2. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. |
