KISS1R Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-13366
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | AXOR 12,AXOR12,G protein coupled receptor 54,G-protein coupled receptor 54,G-protein coupled receptor OT7T175,GPCR 54,GPCR54,GPR 54,GPR54,hOT7T175,Hypogonadotropin 1,Hypogonadotropin-1,Hypogonadotropin1,KISS 1 receptor,KISS 1R,KiSS-1 receptor,KiSS-1R,KISS1 receptor,Kiss1r,Kisspeptins receptor,KISSR,Metastin receptor,OT7T175,KISS1R抗体 |
| Swissprot | Q969F8 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Synthetic peptide of human KISS1R |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cell membrane. |
| Tissue specificity | Most highly expressed in the pancreas, placenta and spinal cord, with lower-level of expression in peripheral blood leukocytes, kidney, lung, fetal liver, stomach, small intestine, testes, spleen, thymus, adrenal glands and lymph nodes. In the adult brain, expressed in the superior frontal gyrus, putamen, caudate nucleus, cingulate gyrus, nucleus accumbens, hippocampus, pons and amygdala, as well as the hypothalamus and pituitary. Expression levels are higher in early (7-9 weeks) than term placentas. Expression levels were increased in both early placentas and molar pregnancies and were reduced in choriocarcinoma cells. Expressed at higher levels in first trimester trophoblasts than at term of gestation. Also found in the extravillous trophoblast suggesting endocrine/paracrine activation mechanism. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | The protein encoded by this gene is a galanin-like G protein-coupled receptor that binds metastin, a peptide encoded by the metastasis suppressor gene KISS1. The tissue distribution of the expressed gene suggests that it is involved in the regulation of endocrine function, and this is supported by the finding that this gene appears to play a role in the onset of puberty. Mutations in this gene have been associated with hypogonadotropic hypogonadism and central precocious puberty. |
