KRAS Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-40187
宿主: Rabbit
反应性: H,M
应用: WB
Overview
| Synonyms | c Ki ras2,c Kirsten ras protein,c-K-ras,c-Ki-ras,Cellular c Ki ras2 proto oncogene,Cellular transforming proto oncogene,CFC2,cK Ras,GTPase KRas,K RAS p21 protein,K RAS2A,K RAS2B,K RAS4A,K RAS4B,K-Ras 2,KI RAS,Ki-Ras,KIRSTEN MURINE SARCOMA VIRUS 2,Kirsten rat sarcoma 2 viral (v Ki ras2) oncogene homolog,Kirsten rat sarcoma viral oncogene homolog,KRAS,KRAS proto oncogene,GTPase,KRAS1,KRAS2,N-terminally processed,NS,NS3,Oncogene KRAS2,p21ras,PR310 c K ras oncogene,PR310 cK ras oncogene,RALD,RASK,RASK2,Transforming protein p21,v Ki ras2 Kirsten rat sarcoma 2 viral oncogene homolog,v Ki ras2 Kirsten rat sarcoma viral oncogene homolog,KRAS抗体 |
| Swissprot | P01116 |
| Source | Rabbit |
| Reactivity | Human,Mouse |
| Immunogen | Recombinant Human GTPase KRas protein |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB 1:500-1:2000 |
| Concentration | 2mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cell membrane. |
| Tissue specificity | Highest expression level in colon |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% Proclin300, 50% glycerol, pH7.4. |
| Background | KRAS,also called p21,is a member of the Ras superfamily of proteins. It is located on human chromosome 12,and contains four coding exons and a 5' non-coding exon (PMID: 12778136). KRAS is a membrane-anchored guanosine triphosphate/guanosine diphosphate (GTP/GDP)-binding protein and is widely expressed in most human cells. Like other members of the Ras family,the KRAS protein is a GTPase,and it is involved in intracellular signal transduction and mainly responsible for EGFR-signaling activation (PMID: 19117687). KRAS mutations have been found in various malignancies,including lung adenocarcinoma,mucinous adenoma,ductal carcinoma of the pancreas and colorectal carcinoma. KRAS has two isoforms,a and b. |
