LEPR Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-53262
宿主: Rabbit
反应性: H
应用: WB,IHC
Overview
| Synonyms | CD 295,CD295,CD295 antigen,Db,Fa,HuB219,LEP R,LEP-R,LEPR,LEPR,LEPRD,Leptin receptor,Leptin receptor fatty,Leptin receptor gene related protein,Leptin receptor precursor,Leptin receptor precursor,OB R gene related protein,OB receptor,OB-R,OB-RGRP,obl,Obr,LEPR抗体 |
| Swissprot | P48357 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Synthetic peptide of human LEPR |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:40-1:200; |
| Concentration | 0.84mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Secreted and Cell membrane. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021). |
