LMNA Polyclonal Antibody
| 规格： | / 50μL / 100μL |
| 价格： | / ￥1010 / ￥1640 |
货号：D-AB-10192L
货期：咨询
宿主: Rabbit
反应性: H,M
应用: WB
Overview
| Synonyms | 70 kDa lamin,Cardiomyopathy dilated 1A (autosomal dominant),CDCD1,CDDC,CMD1A,CMT2B1,EMD2,FPL,FPLD,FPLD2,HGPS,IDC,Lamin A,Lamin A/C,Lamin A/C like 1,Lamin,Lamin C,Lamin-A/C,LDP1,LFP,LGMD1B,Limb girdle muscular dystrophy 1B (autosomal dominant),LMN 1,LMN A,LMN C,LMN1,LMNA,LMNA,LMNC,LMNL1,Prelamin A/C,PRO1,Renal carcinoma antigen NY REN 32,Renal carcinoma antigen NY-REN-32,Renal carcinoma antigen NYREN32 |
| Swissprot | P02545 |
| Source | Rabbit |
| Reactivity | Human,Mouse |
| Immunogen | Recombinant Human LMNA protein expressed by E.coli |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:500-1:1000; |
| Concentration | 1mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus. Nucleus envelope. Farnesylation of prelamin-A/C facilitates nuclear envelope targeting and subsequent cleaveage by ZMPSTE24/FACE1 to remove the farnesyl group produces mature lamin-A/C, which can then be inserted into the nuclear lamina. EMD is required for proper localization of non-farnesylated prelamin-A/C. |
| Tissue specificity | In the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is prevalent in medial vascular smooth muscle celle (VSMCs) from aged individuals and in atherosclerotic lesions, where it often colocalizes with senescent and degenerate VSMCs. Prelamin-A/C expression increases with age and disease. In normal aging, the accumulation of prelamin-A/C is caused in part by the down-regulation of ZMPSTE24/FACE1 in response to oxidative stress. |
| Isotype | IgG |
| Purification | Antigen Affinity Purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,1% protective protein and 50% glycerol,pH7.4 |
| Background | The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. |
