MAD1L1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-14200
宿主: Rabbit
反应性: H,M
应用: WB,IHC
Overview
| Synonyms | hMAD1,HsMAD1,MAD1,MAD1 mitotic arrest deficient like 1 (yeast),MAD1-like protein 1,MAD1L1,MD1L1,Mitotic arrest deficient 1,Mitotic arrest deficient 1-like protein 1,Mitotic checkpoint MAD1 protein homolog,Mitotic spindle assembly checkpoint protein MAD1,PIG9,Tax binding protein 181,Tax-binding protein 181,TP53I9,Tumor protein p53 inducible protein 9,TXBP181,MAD1L1抗体 |
| Swissprot | Q9Y6D9 |
| Source | Rabbit |
| Reactivity | Human,Mouse |
| Immunogen | Recombinant protein of human MAD1L1 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000; |
| Concentration | 0.2 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus. Chromosome>centromere>kinetochore. Cytoplasm>cytoskeleton>microtubule organizing center>centrosome. Cytoplasm>cytoskeleton>spindle. From the beginning to the end of mitosis, it is seen to move from a diffusely nuclear distribution to the centrosome, to the spindle midzone and finally to the midbody. Colocalizes with NEK2 at the kinetochore. |
| Tissue specificity | Expressed weakly at G0/G1 and highly at late S and G2/M phase. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts witHuman, MouseAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Three transcript variants encoding the same protein have been found for this gene. |
