MAP2K2 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-12553
宿主: Rabbit
反应性: H,M,R
应用: WB,IHC
Overview
| Synonyms | Cardiofaciocutaneous syndrome,CFC syndrome,CFC4,Dual specificity mitogen activated protein kinase kinase 2,Dual specificity mitogen-activated protein kinase kinase 2,ERK activator kinase 2,FLJ26075,MAP kinase kinase 2,map2k2,MAPK / ERK kinase 2,MAPK/ERK kinase 2,MAPKK 2,MAPKK2,MEK 2,MEK2,Microtubule associated protein kinase kinase 2,Mitogen activated protein kinase kinase 2,Mitogen activated protein kinase kinase 2 p45,MKK 2,MKK2,MP2K2,OTTHUMP00000165826,OTTHUMP00000165827,PRKMK 2,PRKMK2,MAP2K2抗体 |
| Swissprot | P36507 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic peptide of human MAP2K2 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:1000-1:5000;IHC,,1:100-1:300; |
| Concentration | 1 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoskeleton,microtubule,Cytosol,Endoplasmic reticulum,endoplasmic reticulum,Endosome,early endosome,late endosome,Extracellular region or secreted,extracellular region,Golgi apparatus,Golgi apparatus,Mitochondrion,Nucleus,Peroxisome,peroxisomal membrane,Plasma Membrane,cytoplasmic side of Plasma Membrane,Other locations:cell-cell junction,focal adhesion,perinuclear region of cytoplasm |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. |
Images
Western Blot analysis of Hela, NIH/3T3 and Jurkat cell using MAP2K2 Polyclonal Antibody at dilution of 1:1900
Immunohistochemistry of paraffin-embedded Human gastic cancer using MAP2K2 Polyclonal Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded Human ovarian cancer using MAP2K2 Polyclonal Antibody at dilution of 1:100
