MCTS1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-15193
宿主: Rabbit
反应性: H
应用: WB,IHC
Overview
| Synonyms | FLJ39637,Malignant T cell-amplified sequence 1,MCT 1,MCT-1,MCT1,MCTS 1,MCTS1,MCTS1,Multiple copies T cell malignancies 1,Multiple copies T cell malignancies,Multiple copies T-cell malignancies,Oncogene MCT 1,Oncogene MCT1,MCTS1抗体 |
| Swissprot | Q9ULC4 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Recombinant protein of human MCTS1 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:200-1:1000;IHC,,1:100-1:300; |
| Concentration | 0.2 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Nuclear relocalization after DNA damage. |
| Tissue specificity | Ubiquitous. Over-expressed in T-cell lymphoid cell lines and in non-Hodgkin lymphoma cell lines as well as in a subset of primary large B-cell lymphomas. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | MCTS1 (malignant T cell amplified sequence 1), also known as MCT1, is a 181 amino acid protein that is ubiquitously expressed and localizes to the cytoplasm of cells. MCTS1 may play a role in cell cycle regulation by decreasing cell doubling time and by shortening the duration of G1 transit time and G1/S transition. The protein level of Cdk4 and Cdk6 kinases activity and cyclin D1 is enhanced by expression of MCTS1. As a translation enhancer, MCTS1 recruits DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile. MCTS1 promotes lymphoid tumor development and contributes to the pathogenesis and progression of breast cancer. MCTS1 positively regulates phosphorylation of ERK1 and ERK2. |
Images
Western Blot analysis of Jurkat and PC3 cell using MCTS1 Polyclonal Antibody at dilution of 1:200
Immunohistochemistry of paraffin-embedded Human thyroid cancer using MCTS1 Polyclonal Antibody at dilution of 1:60
Immunohistochemistry of paraffin-embedded Human brain using MCTS1 Polyclonal Antibody at dilution of 1:60
