MICA Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-18241
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | HLA class I antigen,FLJ36918,FLJ60820,MGC111087,MGC21250,MHC class I chain related gene A protein,MHC class I chain related protein A,MHC class I chain related protein A HLA B HLA C,MHC class I polypeptide related sequence A,MHC class I polypeptide-related sequence A,MHC class I related protein,MIC A,MIC-A,micA,MICA,OTTHUMP00000029088,OTTHUMP00000044528,OTTHUMP00000165170,OTTHUMP00000165172,PERB11.1,Stress inducible class I homolog,MICA抗体 |
| Swissprot | Q29983 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Fusion protein of human MICA |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 0.6mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cell membrane. Cytoplasm. Expressed on the cell surface in gastric epithelium, endothelial cells and fibroblasts and in the cytoplasm in keratinocytes and monocytes. Infection with human adenovirus 5 suppresses cell surface expression due to the adenoviral E3-19K protein which causes retention in the endoplasmic reticulum. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. |
