MICU1 Monoclonal Antibody
| 规格： | / 20μL / 60μL / 120μL |
| 价格： | / ￥580 / ￥1420 / ￥2310 |
货号：E-AB-22114
宿主: Mouse
反应性: H,M,R
应用: WB,IHC-p,IF
Overview
| Synonyms | Allergen Hom s 4,ara CALC,atopy related autoantigen,atopy related autoantigen CALC,Atopy-related autoantigen CALC,CALC,calcium binding atopy related autoantigen 1,Calcium uptake protein 1,calcium uptake protein 1,mitochondrial,Calcium-binding atopy-related autoantigen 1,CBARA1,EFHA3,FLJ12684,MICU1,MICU1,mitochondrial,mitochondrial calcium uptake 1,MPXPS,MICU1抗体 |
| Swissprot | Q9BPX6 |
| Source | Mouse |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant Protein |
| Application | WB(Detection kit: E-IR-R304),IHC-p(Detection kit: E-IR-R213),IF |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:100-1:200;IF,,1:100-1:300; |
| Concentration | 1mg/mL |
| Clonality | Monoclonal |
Properties
| Cellular localization | Mitochondrion inner membrane. |
| Tissue specificity | Expressed in epithelial cell line. Strongly expressed in epidermal keratinocytes and dermal endothelial cells. |
| Clone No | Clone:4E7 |
|---|---|
| Isotype | IgG |
| Purification | Protein A purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.4 |
| Background | This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described. MICU1 (Mitochondrial Calcium Uptake 1) is a Protein Coding gene. Diseases associated with MICU1 include Myopathy With Extrapyramidal Signs and Fish Allergy. Among its related pathways are Ca, cAMP and Lipid Signaling. GO annotations related to this gene include calcium ion binding and protein heterodimerization activity. An important paralog of this gene is MICU3. |
Images
Western Blot analysis of 1) MCF7, 2) Mouse brain, 3) Rat brain with MICU1 Monoclonal Antibody.
Immunohistochemistry of paraffin-embedded Mouse testis tissue using MICU1 Monoclonal Antibody at dilution of 1:200.
Immunofluorescence analysis of Human appendix tissue using MICU1 Monoclonal Antibody at dilution of 1:200.
