MKP-3 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-10308
宿主: Rabbit
反应性: H,M,R
应用: WB,IHC
Overview
| Synonyms | Dual specificity phosphatase 6,Dual specificity phosphatase 6 isoform a,Dual specificity protein phosphatase 6,Dual specificity protein phosphatase PYST1,DUS6,DUSP 6,DUSP 6a,Dusp6,DUSP6a,HH19,MAP kinase phosphatase 3,Mitogen activated protein kinase phosphatase 3,Mitogen-activated protein kinase phosphatase 3,MKP 3,MKP-3,MKP3,PYST 1,PYST1,Serine/threonine specific protein phosphatase,DUSP6抗体 |
| Swissprot | Q16828 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein of human DUSP6 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000; |
| Concentration | 0.4 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. |
Images
Western Blot analysis of Jurkat cell and Human fetal kidney tissue using MKP-3 Polyclonal Antibody at dilution of 1:450
Immunohistochemistry of paraffin-embedded Human ovarian cancer using MKP-3 Polyclonal Antibody at dilution of 1:25
Immunohistochemistry of paraffin-embedded Human tonsil using MKP-3 Polyclonal Antibody at dilution of 1:25
