MLANA Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-19522
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | Antigen LB39 AA,Antigen LB39-AA,Antigen SK29 AA,Antigen SK29-AA,MAR1,MART 1,MART-1,MART1,Melan A,Melan A protein,Melanoma antigen recognized by T cells 1,Melanoma antigen recognized by T-cells 1,MLAN A,MLANA,OTTHUMP00000021036,OTTHUMP00000021037,OTTHUMP00000021038,Protein Melan-A,MLANA抗体 |
| Swissprot | Q16655 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Synthetic peptide of human MLANA |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:40-1:250 |
| Concentration | 1mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Endoplasmic reticulum membrane. Golgi apparatus. Golgi apparatus>trans-Golgi network membrane. Melanosome. Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | Melan-A is a melanocyte differentiation antigen,recognized by autologous cytotoxic T lymphocytes. Melan-A is also called MART-1 (melanoma antigen recognized by T cells). The Melan-A/MART-1 gene encodes this protein,20-22 kDa,associated with endoplasmic reticulum and melanosomes. The function of the protein is unknown. Melan-A,isolated as a melanoma-specific antigen,is a transmembrane protein,which is expressed in skin,retina and the majority of cultured melanocytes as well as in melanomas. Melan A is expressed in more than 85% of melanomas. |
