MMP2 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-13064
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | 72 kDa gelatinase,72kD type IV collagenase,CLG 4,CLG 4A,CLG4,CLG4A,Collagenase Type 4 alpha,Collagenase type IV A,Gelatinase A,Gelatinase alpha,Gelatinase neutrophil,Matrix metallopeptidase 2 gelatinase A 72kDa gelatinase 72kDa type IV collagenase,Matrix metalloproteinase 2 (gelatinase A,72kDa gelatinase,72kDa type IV collagenase),Matrix Metalloproteinase 2,Matrix metalloproteinase II,Matrix metalloproteinase-2,MMP 2,MMP II,MMP-2,MMP2,MMP2,MONA,Neutrophil gelatinase,PEX,TBE 1,TBE-1,MMP2抗体 |
| Swissprot | P08253 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic peptide of human MMP2 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 1.2 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Secreted>extracellular space>extracellular matrix. Membrane. Nucleus. Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas. Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes. |
| Tissue specificity | Produced by normal skin fibroblasts. PEX is expressed in a number of tumors including gliomas, breast and prostate. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. |
