MMP2 Polyclonal Antibody
| 规格： | / 60μL / 120μL / 200μL |
| 价格： | / ￥1380 / ￥2220 / ￥3300 |
货号：E-AB-70057
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | 72 kDa gelatinase,72kD type IV collagenase,CLG 4,CLG 4A,CLG4,CLG4A,Collagenase Type 4 alpha,Collagenase type IV A,Gelatinase A,Gelatinase alpha,Gelatinase neutrophil,Matrix metallopeptidase 2 gelatinase A 72kDa gelatinase 72kDa type IV collagenase,Matrix metalloproteinase 2 (gelatinase A,72kDa gelatinase,72kDa type IV collagenase),Matrix Metalloproteinase 2,Matrix metalloproteinase II,Matrix metalloproteinase-2,MMP 2,MMP II,MMP-2,MMP2,MMP2,MONA,Neutrophil gelatinase,PEX,TBE 1,TBE-1,MMP2抗体 |
| Swissprot | P08253,P33436,P33434 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse MMP2 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:500-1:2000; |
| Concentration | 0.82 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Secreted>extracellular space>extracellular matrix. Membrane. Nucleus. Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas. Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes. |
| Tissue specificity | Produced by normal skin fibroblasts. PEX is expressed in a number of tumors including gliomas, breast and prostate.Highest expression level in mucosa of stomach. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
| Background | MMP2,also named as CLG4A,Gelatinase Am,TBE-1 and PEX,belongs to the peptidase M10A family. It is ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature,angiogenesis,tissue repair,tumor invasion,inflammation,and atherosclerotic plaque rupture. MMP2 contributes to myocardial oxidative stress by regulating the activity of GSK3beta. It cleaves GSK3beta in vitro. MMP2 can be cleaved into PEX chain(~60kd).Western blot analysis showed that the 72 kDa and 62 kDa proteinase activities were pro-MMP2 and the active enzyme,respectively. |
Images
Immunohistochemistry analysis of paraffin-embedded human colon cancer using MMP2 Polyclonal Antibody at dilution of 1:500.
Immunohistochemistry analysis of paraffin-embedded rat colon using MMP2 Polyclonal Antibody at dilution of 1:500.
Immunohistochemistry analysis of paraffin-embedded mouse uterus using MMP2 Polyclonal Antibody at dilution of 1:500.
Immunohistochemistry analysis of paraffin-embedded Human Spleen using MMP2 Polyclonal Antibody(Elabscience® Product Detected by Lifespan).
