Mouse IL-1β(Interleukin 1 Beta) ELISA Kit
小鼠白介素1β(IL-1β)酶联免疫吸附测定试剂盒
| 规格： | / 96T / 48T / 96T*5 |
| 价格： | / ￥2400 / ￥1650 / ￥10200 |
货号：E-EL-M0037
反应性: 小鼠
检测范围: 7.81~500 pg/mL
灵敏度: 4.69 pg/mL
用途
该试剂盒用于体外定量检测小鼠serum, plasma and other biological fluids中IL-1β浓度
检测原理
本试剂盒采用双抗体夹心ELISA法。用抗小鼠IL-1β抗体包被于酶标板上，实验时样品或标准品中的小鼠IL-1β会与包被抗体结合，游离的成分被洗去。依次加入生物素化的抗小鼠IL-1β抗体和辣根过氧化物酶标记的亲和素。抗小鼠IL-1β抗体与结合在包被抗体上的小鼠IL-1β结合、生物素与亲和素特异性结合而形成免疫复合物，游离的成分被洗去。加入显色底物(TMB)，TMB在辣根过氧化物酶的催化下呈现蓝色，加终止液后变成黄色。用酶标仪在450nm波长处测OD值，IL-1β浓度与OD450值之间呈正比，通过绘制标准曲线计算出样品中IL-1β的浓度。
| 反应类型 | 夹心法 |
| 规格 | 96T |
| 反应时间 | 3.5h |
| 反应性 | 小鼠 |
| 检测方法 | Colormetric |
| 检测范围 | 7.81—500 pg/mL |
| 灵敏度 | 4.69 pg/mL |
| 样本体积 | 100μL |
| 样本类型 | serum, plasma and other biological fluids |
特异性
可检测样本中的小鼠IL-1β，且与其它相关蛋白无明显交叉反应。
重复性
板内，板间变异系数均<10%。
典型数据
由于实验操作条件的不同（如操作者、移液技术、洗板技术和稳定条件等），标准曲线的OD值会有所差异。以下数据和曲线仅供参考，实验者需根据自己的实验建立标准曲线。
| (pg/mL) | O.D | Average | Corrected |
|---|---|---|---|
| 500 | 2.468 2.484 |
2.476 | 2.417 |
| 250 | 1.547 1.603 |
1.575 | 1.516 |
| 125 | 0.953 0.951 |
0.952 | 0.893 |
| 62.5 | 0.47 0.492 |
0.481 | 0.422 |
| 31.25 | 0.246 0.236 |
0.241 | 0.182 |
| 15.63 | 0.167 0.155 |
0.161 | 0.102 |
| 7.81 | 0.107 0.115 |
0.111 | 0.052 |
| 0 | 0.056 0.062 |
0.059 | -- |
精密度
板内精密度:低浓度样本,中浓度样本和高浓度样本分别在1块板子上检测20次。
板间精密度:低浓度样本,中浓度样本和高浓度样本分别在3块板子上检测20次。
| Intra-assay Precision | Inter-assay Precision | |||||
|---|---|---|---|---|---|---|
| Sample | 1 | 2 | 3 | 1 | 2 | 3 |
| n | 20 | 20 | 20 | 20 | 20 | 20 |
| Mean (pg/mL) |
26.40 | 59.30 | 201.20 | 27.30 | 57.80 | 199.40 |
| Standard
deviation |
1.70 | 3.20 | 10.10 | 1.80 | 2.40 | 8.80 |
| C V (%) | 6.44 | 5.40 | 5.02 | 6.59 | 4.15 | 4.41 |
回收率
分别往5个不同样本中添加已知浓度的目标蛋白，做回收实验，得出回收率范围和平均回收率。
| Sample Type | Range (%) | Average Recovery (%) |
|---|---|---|
| Serum (n=5) | 88-103 | 96 |
| EDTA plasma (n=5) | 91-104 | 97 |
| Cell culture media (n=5) | 91-107 | 98 |
线性
分别往5个样本中添加已知浓度的目标蛋白，做回收实验，得出回收率范围及平均回收率。将5个样本分别稀释2倍，4倍，8倍，16倍做回收实验，得出回收率范围及平均回收率。
| Serum (n=5) | EDTA plasma (n=5) | Cell culture media (n=5) | ||
|---|---|---|---|---|
| 1:2 | Range (%) | 89-101 | 96-107 | 85-99 |
| Average (%) | 95 | 101 | 92 | |
| 1:4 | Range (%) | 98-112 | 86-98 | 92-109 |
| Average (%) | 105 | 93 | 100 | |
| 1:8 | Range (%) | 98-116 | 86-99 | 93-105 |
| Average (%) | 106 | 91 | 100 | |
| 1:16 | Range (%) | 98-113 | 85-97 | 91-104 |
| Average (%) | 107 | 91 | 97 |
试剂盒组成及保存
未拆封的试剂盒可在4℃保存一周；如果一周以后才使用试剂盒，请拆开试剂盒按照下表中的条件分别保存各组分。
| 中文名称 | 英文名称 | 规格 | 保存条件 |
|---|---|---|---|
| ELISA酶标板(可拆卸) | Micro ELISA Plate(Dismountable) | 8 孔×12 条 | -20℃，可存放6个月 |
| 冻干标准品 | Reference Standard | 2 支 | |
| 浓缩生物素化抗体(100×) | Concentrated Biotinylated Detection Ab | 1支 120 μL | |
| 浓缩HRP酶结合物(100×) | Concentrated HRP Conjugate | 1支 120 μL | -20℃(避光)，可存放6个月 |
| 标准品&样品稀释液 | Reference Standard & Sample Diluent | 1瓶 20 mL | 4℃.可存放6个月 |
| 生物素化抗体稀释液 | Biotinylated Detection Ab Diluent | 1瓶 14 mL | |
| 酶结合物稀释液 | HRP Conjugate Diluent | 1瓶 14 mL | |
| 浓缩洗涤液(25×) | Concentrated Wash Buffer (25×) | 1瓶 30 mL | |
| 底物溶液(TMB) | Substrate Reagent | 1瓶 10 mL | 4℃(避光) |
| 反应终止液 | Stop Solution | 1瓶 10 mL | 4℃ |
| 封板覆膜 | Plate Sealer | 5 张 | |
| 产品说明书 | Product Description | 1 份 | |
| 质检报告 | Certificate of Analysis | 1 份 |
说明：所有试剂瓶盖须旋紧以防止蒸发和微生物的污染。
试剂体积以实际发货版说明书为准。相关试剂在分装时会比标签上标明的体积稍多一些，请在使用时量取而非直接倒出。
试验所需自备物品
- 1. 酶标仪(450nm波长滤光片)
- 2. 高精度移液器，EP管及一次性吸头：0.5-10 μL, 2-20 μL, 20-200 μL, 200-1000 μL
- 3. 37℃恒温箱，双蒸水或去离子水
- 4. 吸水纸
操作步骤
|
|
1.对应板孔中加入100μL标准品工作液或样本，37℃孵育90分钟 |
| 2.弃掉板内液体后，立即加入100μL生物素化抗体工作液，37℃孵育60分钟 | |
| 3.弃掉板内液体，洗板3次 | |
| 4.每孔加入100μL HRP酶结合物工作液，37℃孵育30分钟，弃掉板内液体，洗板5次 | |
| 5.每孔加入90μL底物溶液，37℃孵育15分钟 | |
| 6.每孔加入50μL终止液 | |
| 7.立即在450nm波长下读数，处理数据 |
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样品类型: Tissue homogenate - 文献: Pseudolaric acid B ameliorates synovial inflammation and vessel formation by stabilizing PPARγ to inhibit NF-κB signalling pathway
样品类型: Raw 264.7 cells - 文献: A comparative study of fermented buffalo and camel milk with anti-inflammatory, ACE-inhibitory and anti-diabetic properties and release of bio active peptides with molecular interactions: In vitro, in silico and molecular study
样品类型: RAW 264.7 cell - 文献: Tetrahydrocurcumin improves lipopolysaccharide-induced myocardial dysfunction by inhibiting oxidative stress and inflammation via JNK/ERK signaling pathway regulation
样品类型: serum - 文献: Bioactive constituents of Mosla chinensis-cv. Jiangxiangru ameliorate inflammation through MAPK signaling pathways and modify intestinal microbiota in DSS-induced colitis mice
样品类型: colon tissue - 文献: Bioactivity-guided isolation of the major anthocyanin from Lycium ruthenicum Murr. fruit and its antioxidant activity and neuroprotective effects in vitro and in vivo
样品类型: hippocampus - 文献: Bioactives and their metabolites from Tetrastigma hemsleyanum leaves ameliorate DSS-induced colitis via protecting intestinal barrier, mitigating oxidative stress and regulating gut microbiota
样品类型: colon tissue - 文献: Full-length transcriptome analysis reveals the mechanism of acupuncture at PC6 improves cardiac function in myocardial ischemia model
样品类型: serum - 文献: Anti-inflammatory effects of anemonin on acute ulcerative colitis via targeted regulation of protein kinase C-θ
样品类型: colon tissues - 文献: A novel mechanism of diabetic vascular endothelial dysfunction: Hypoadiponectinemia-induced NLRP3 inflammasome activation
样品类型: Serum,Cell culture supernatant - 文献: Encapsulation of Functional Plant Oil by Spray Drying: Physicochemical Characterization and Enhanced Anti-Colitis Activity
样品类型: serum - 文献: Selective GSK3β Inhibition Mediates an Nrf2-Independent Anti-inflammatory Microglial Response
样品类型: SIM-A9 cell - 文献: Broccoli microgreens juice reduces body weight by enhancing insulin sensitivity and modulating gut microbiota in high-fat diet-induced C57BL/6J obese mice
样品类型: Serum - 文献: Oral administration of 3,3′-diselenodipropionic acid prevents thoracic radiation induced pneumonitis in mice by suppressing NF-kB/IL-17/G-CSF/neutrophil axis
样品类型: Bronchoalveolar Lavage Fluid,Tissue homogenate - 文献: LncRNA Tug1 Contributes Post-stroke NLRP3 Inflammasome-Dependent Pyroptosis via miR-145a-5p/Tlr4 Axis
样品类型: serum,BV-2 cell - 文献: Investigating the mechanisms of Modified Xiaoyaosan (tiaogan-liqi prescription) in suppressing the progression of atherosclerosis, by means of integrative pharmacology and experimental validation
样品类型: Plasma - 文献: CHIP ameliorates cerebral ischemia-reperfusion injury by attenuating necroptosis and inflammation
样品类型: brain - 文献: Baicalin ameliorates neuroinflammation-induced depressive-like behavior through inhibition of toll-like receptor 4 expression via the PI3K/AKT/FoxO1 pathway
样品类型: hippocampus tissue,BV2 cells,primary microglia cells - 文献: Sustained activation of NLRP3 inflammasome contributes to delayed wound healing in aged mice
样品类型: serum - 文献: Caspase-8 is involved in pyroptosis, necroptosis and the maturation and release of IL-1β in Aspergillus fumigatus keratitis
样品类型: RAW264.7 cells - 文献: C1q/tumor necrosis factor-related protein-6 exerts protective effects on myocardial ischemia–reperfusion injury through the modulation of the Akt-GSK-3β-Nrf2 signaling cascade
样品类型: cardiac muscle tissues,cardiomyocytes - 文献: Spatial Training Ameliorates Long-Term Alzheimer’s Disease-Like Pathological Deficits by Reducing NLRP3 Inflammasomes in PR5 Mice
样品类型: Tissue homogenate - 文献: Procyanidin B2 Attenuates Nicotine-Induced Hepatocyte Pyroptosis through a PPARγ-Dependent Mechanism
样品类型: serums,hepatocytes - 文献: Friedelin Alleviates the Pathogenesis of Collagenase-Induced Tendinopathy in Mice by Promoting the Selective Autophagic Degradation of p65
样品类型: serum,tenocytes - 文献: Drug D, a Diosgenin Derive, Inhibits L-Arginine-Induced Acute Pancreatitis through Meditating GSDMD in the Endoplasmic Reticulum via the TXNIP/HIF-1α Pathway
样品类型: pancreatic tissue - 文献: A Lard and Soybean Oil Mixture Alleviates Low-Fat–High-Carbohydrate Diet-Induced Nonalcoholic Fatty Liver Disease in Mice
样品类型: liver - 文献: Salidroside Ameliorates Alzheimer's Disease by Targeting NLRP3 Inflammasome-Mediated Pyroptosis
样品类型: brain tissue,PC12 cell - 文献: Agomelatine Prevents Amyloid Plaque Deposition, Tau Phosphorylation, and Neuroinflammation in APP/PS1 Mice
样品类型: hippocampus tissue - 文献: TNF‐α/HMGB1 inflammation signalling pathway regulates pyroptosis during liver failure and acute kidney injury
样品类型: serum - 文献: Systemic exosomal miR-193b-3p delivery attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage in mice
样品类型: brain - 文献: Wu-Mei-Wan Ameliorates Murine Ulcerative Colitis by Regulating Macrophage Polarization
样品类型: Serum - 文献: The Effect of Shionone on Sepsis-Induced Acute Lung Injury by the ECM1/STAT5/NF-κB Pathway
样品类型: serum,RAW264.7 cell - 文献: Oroxylin a Attenuates Limb Ischemia by Promoting Angiogenesis via Modulation of Endothelial Cell Migration
样品类型: muscle，serum - 文献: Naringin Interferes Doxorubicin-Induced Myocardial Injury by Promoting the Expression of ECHS1
样品类型: heart tissue - 文献: Ethyl 2-Succinate-Anthraquinone Attenuates Inflammatory Response and Oxidative Stress via Regulating NLRP3 Signaling Pathway.
样品类型: blood - 文献: Anti-Epileptic Effect of Crocin on Experimental Temporal Lobe Epilepsy in Mice
样品类型: cortex,hippocampus - 文献: Rice Protein Peptides Alleviate Dextran Sulfate Sodium-Induced Colitis via the Keap1–Nrf2 Signaling Pathway and Regulating Gut Microbiota
样品类型: colon tissue - 文献: Terazosin Stimulates Pgk1 to Remedy Gastrointestinal Disorders
样品类型: colon tissue - 文献: N-Acetyl cysteine effectively alleviates Coxsackievirus B-Induced myocarditis through suppressing viral replication and inflammatory response
样品类型: heart - 文献: MiR-146b-5p/TRAF6 axis is essential for Ginkgo biloba L. extract GBE to attenuate LPS-induced neuroinflammation
样品类型: BV-2 cell - 文献: Metformin Alleviates LPS-Induced Acute Lung Injury by Regulating the SIRT1/NF-κB/NLRP3 Pathway and Inhibiting Endothelial Cell Pyroptosis
样品类型: lung tissue,Pulmonary ECs - 文献: PGC-1 silencing compounds the perturbation of mitochondrial function caused by mutant SOD1 in skeletal muscle of ALS mouse model
样品类型: Serum - 文献: A Natural Plant Ingredient, Menthone, Regulates T Cell Subtypes and Lowers Pro-inflammatory Cytokines of Rheumatoid Arthritis
样品类型: blood - 文献: Xiaoyaosan prevents atherosclerotic vulnerable plaque formation through heat shock protein/glucocorticoid receptor axis-mediated mechanism
样品类型: serum - 文献: Vascular endothelial Cdc42 deficiency delays skin wound-healing processes by increasing IL-1β and TNF-α expression
样品类型: skin tissues - 文献: Upregulation of the P2X7 receptor promotes Ca2+ accumulation and inflammatory response in post-stroke depression
样品类型: serum - 文献: Ameliorative effects of snake (Deinagkistrodon acutus) oil and its main fatty acids against UVB-induced skin photodamage in mice
样品类型: skin - 文献: Sesamin suppresses advanced glycation end products induced microglial reactivity using BV2 microglial cell line as a model
样品类型: Cell culture medium - 文献: Selenium Supplementation Protects Against Arsenic-Trioxide-Induced Cardiotoxicity Via Reducing Oxidative Stress and Inflammation Through Increasing NAD+ Pool
样品类型: heart tissue - 文献: Preparation, Characterization, and Immuno-Enhancing Activity of Polysaccharides from Glycyrrhiza uralensis
样品类型: Cell culture supernatant,Cell sample - 文献: Protective Effect of Prunus mume Fermented with Mixed Lactic Acid Bacteria in Dextran Sodium Sulfate-Induced Colitis
样品类型: colon tissue,serum - 文献: Benzoylaconine Modulates LPS-Induced Responses Through Inhibition of Toll-Like Receptor-Mediated NF-κB and MAPK Signaling in RAW264.7 Cells
样品类型: RAW264.7 cells - 文献: Resveratrol ameliorates nutritional steatohepatitis through the mmu‑miR‑599/PXR pathway
样品类型: serum - 文献: Melatonin attenuates prostatic inflammation and pelvic pain via Sirt1-dependent inhibition of the NLRP3 inflammasome in an EAP mouse model
样品类型: serum - 文献: Upregulation of FAM129B protects cardiomyocytes from hypoxia/reoxygenation-induced injury by inhibiting apoptosis, oxidative stress, and inflammatory response via enhancing Nrf2/ARE activation
样品类型: cardiomyocytes - 文献: Inhibition of USP15 ameliorates high-glucose-induced oxidative stress and inflammatory injury in podocytes through regulation of the Keap1/Nrf2 signaling
样品类型: MPC5 cell - 文献: Effects of 2,4-dichlorophenoxyacetic acid on the expression of NLRP3 inflammasome and autophagy-related proteins as well as the protective effect of Lycium barbarum polysaccharide in neonatal rats
样品类型: BV2 cell - 文献: 2,4-dichlorophenoxyacetic acid induces ROS activation in NLRP3 inflammatory body-induced autophagy disorder in microglia and the protective effect of Lycium barbarum polysaccharide
样品类型: BV2 cell - 文献: Ageratina adenophora induces mice hepatotoxicity via ROS-NLRP3-mediated pyroptosis
样品类型: Serum,Tissue homogenate - 文献: Extracellular Histone H3 Induces Pyroptosis During Sepsis and May Act Through NOD2 and VSIG4/NLRP3 Pathways
样品类型: Cell culture supernatant - 文献: Didymin Ameliorates Liver Fibrosis by Alleviating Endoplasmic Reticulum Stress and Glycerophospholipid Metabolism: Based on Transcriptomics and Metabolomics
样品类型: liver - 文献: Melatonin as an inducer of arecoline and their coordinated roles in anti-oxidative activity and immune responses
样品类型: Plasma - 文献: Flaxseed oligosaccharides alleviate DSS-induced colitis through modulation of gut microbiota and repair of the intestinal barrier in mice
样品类型: Serum,Tissue homogenate - 文献: Akebia trifoliata pericarp extract ameliorates inflammation through NF-κB/MAPK signaling pathways and modifies gut microbiota
样品类型: colon tissue - 文献: Salidroside Ameliorates Renal Interstitial Fibrosis by Inhibiting the TLR4/NF-κB and MAPK Signaling Pathways
样品类型: Serum - 文献: O-alkyl and o-benzyl hesperetin derivative-1L attenuates inflammation and protects against alcoholic liver injury via inhibition of BRD2-NF-κB signaling pathway
样品类型: serum,RAW264.7 cell - 文献: Immunization With a Secreted Esterase Protects Mice Against Multiple Serotypes (M1, M3, and M28) of Group A Streptococcus
样品类型: skin - 文献: Algal Oil Rich in n-3 PUFA Alleviates DSS-Induced Colitis via Regulation of Gut Microbiota and Restoration of Intestinal Barrier
样品类型: serum - 文献: Exploring the potential of Lactobacillus and Saccharomyces for biofunctionalities and the release of bioactive peptides from whey protein fermentate
样品类型: RAW264.7 cell - 文献: Exploring potentials of antioxidative, anti-inflammatory activities and production of bioactive peptides in lactic fermented camel milk
样品类型: RAW 264.7 cell - 文献: Antioxidative, antimicrobial and anti-inflammatory activities and release of ultra-filtered antioxidative and antimicrobial peptides during fermentation of sheep milk: In-vitro, in-silico and molecular interaction studies
样品类型: RAW 264.7 murine macrophage cell - 文献: Glycyrrhiza uralensis water extract enhances dendritic cell maturation and antitumor efficacy of HPV dendritic cell-based vaccine
样品类型: Cell culture supernatant - 文献: Identification and molecular mechanisms of novel antioxidative peptides from fermented camel milk (Kachchi breed, India) with anti-inflammatory activity in raw macrophages cell lines
样品类型: RAW 264.7 cells - 文献: Antidiabetic, angiotensin-converting enzyme inhibitory and anti-inflammatory activities of fermented camel milk and characterisation of novel bioactive peptides from lactic-fermented camel milk with molecular interaction study
样品类型: RAW 264.7 cell - 文献: Calcium channel antagonists interfere with the mechanism of action of elastin-derived peptide VGVAPG in mouse cortical astrocytes in vitro
样品类型: astrocyte cell - 文献: Green Pea (Pisum sativum L.) Hull Polyphenol Extracts Ameliorate DSS-Induced Colitis through Keap1/Nrf2 Pathway and Gut Microbiota Modulation
样品类型: colon - 文献: Tanshinol alleviates ulcerative colitis by promoting the expression of VLDLR
样品类型: colon - 文献: Modulation of LPA1 receptor-mediated neuronal apoptosis by Saikosaponin-d: A target involved in depression
样品类型: hippocampus tissue - 文献: Adenosine receptor A2B mediates alcoholic hepatitis by regulating cAMP levels and the NF-KB pathway
样品类型: serum,RAW264.7 cell - 文献: The protective effect of the PDE-4 inhibitor rolipram on intracerebral haemorrhage is associated with the cAMP/AMPK/SIRT1 pathway
样品类型: Brain tissue - 文献: Studies on the mitochondrial, immunological and inflammatory effects of solvent fractions of Diospyros mespiliformis Hochst in Plasmodium berghei-infected mice
样品类型: Serum - 文献: Hepatoprotective effect of Thymus vulgaris extract on sodium nitrite-induced changes in oxidative stress, antioxidant and inflammatory marker expression
样品类型: Serum - 文献: The therapeutic potential of chondroitin sulfate in Aspergillus fumigatus keratitis
样品类型: corneas,RAW 264.7 cell - 文献: The Expression and Bioinformatics Analysis of Circular RNAs in Endometritis Mouse Uterus Tissues
样品类型: uterine tissue - 文献: Eriodictyol and Homoeriodictyol Improve Memory Impairment in Aβ25–35-Induced Mice by Inhibiting the NLRP3 Inflammasome
样品类型: brain - 文献: Lactobacillus acidophilus Exerts Neuroprotective Effects in Mice with Traumatic Brain Injury
样品类型: Serum,Tissue homogenate - 文献: Peripheral Administration of a Cell-Penetrating MOTS-c Analogue Enhances Memory and Attenuates Aβ1–42- or LPS-Induced Memory Impairment through Inhibiting Neuroinflammation
样品类型: Tissue homogenate(hippocampus) - 文献: Seizure-induced neuroinflammation contributes to ectopic neurogenesis and aggressive behavior in pilocarpine-induced status epilepticus mice
样品类型: Cell lysate - 文献: Research on the effect and underlying molecular mechanism of Cangzhu in the treatment of gouty arthritis
样品类型: RAW264.7-cell - 文献: Phillygenin inhibited LPS-induced RAW 264.7 cell inflammation by NF-κB pathway
样品类型: Cell culture supernatant - 文献: Laccase-mediated functionalization of natamycin by gallic acids for the therapeutic effect on Aspergillus fumigatus keratitis
样品类型: corneas,RAW264.7 cell - 文献: Intervention of 3-aminobenzamide against Dextran Sulphate Sodium induced colitis in mice: Investigations on molecular mechanisms
样品类型: Colon - 文献: Structural characterization and immunomodulatory activity of a glucan from Radix Codonopsis
样品类型: Cell culture supernatant - 文献: Antioxidative mechanisms and anticolitic potential of Desmodium styracifolium (Osb.) Merr. in DSS-induced colitic mice
样品类型: colonic tissue - 文献: Dihydrokaempferol attenuates CCl4-induced hepatic fibrosis by inhibiting PARP-1 to affect multiple downstream pathways and cytokines
样品类型: serum - 文献: Terpene-rich fractions of Ficus mucoso (Welw) modulate lipopolysaccharide-induced inflammatory mediators and aberrant permeability of the inner mitochondrial membrane in murine animal model
样品类型: serum - 文献: Polysaccharides from Dicliptera chinensis ameliorate liver disturbance by regulating TLR‐4/NF‐κB and AMPK/Nrf2 signalling pathways
样品类型: Serum,Tissue homogenate - 文献: MG53 Protects hUC-MSCs against Inflammatory Damage and Synergistically Enhances Their Efficacy in Neuroinflammation Injured Brain through Inhibiting NLRP3/Caspase-1/IL-1β Axis
样品类型: Serum - 文献: Autophagy Activation Represses Pyroptosis through the IL-13 and JAK1/STAT1 Pathways in a Mouse Model of Moderate Traumatic Brain Injury
样品类型: Plasma - 文献: Integrative Analysis of Transcriptome and Metabolome to Illuminate the Protective Effects of Didymin against Acute Hepatic Injury
样品类型: Serum - 文献: Study on the protective effect and mechanism of Dicliptera chinensis (L.) Juss (Acanthaceae) polysaccharide on immune liver injury induced by LPS
样品类型: Tissue homogenate - 文献: Anti-inflammatory Effect of a Limonin Derivative In Vivo and Its Mechanisms in RAW264.7 Cells
样品类型: Raw 264.7 cell - 文献: Intranasal MMI-0100 Attenuates Aβ1−42- and LPS-Induced Neuroinflammation and Memory Impairments via the MK2 Signaling Pathway
样品类型: Tissue homogenate - 文献: Electroacupuncture Ameliorates Intestinal Barrier Destruction in Mice With Bile Duct Ligation–Induced Liver Injury by Activating the Cholinergic Anti-Inflammatory Pathway
样品类型: plasma - 文献: Lipopolysaccharide exacerbates chronic restraint stress-induced neurobehavioral deficits: Mechanisms by redox imbalance, ASK1-related apoptosis, autophagic dysregulation
样品类型: serum,brain - 文献: Isorhamnetin Ameliorates Aspergillus fumigatus Keratitis by Reducing Fungal Load, Inhibiting Pattern-Recognition Receptors and Inflammatory Cytokines
样品类型: Tissue homogenate(corneas) - 文献: Salidroside ameliorates Parkinson's disease by inhibiting NLRP3-dependent pyroptosis
样品类型: Cell culture supernatant,Tissue homogenate - 文献: Lipopolysaccharide upregulates miR-132/212 in Hirschsprung-associated enterocolitis, facilitating pyroptosis by activating NLRP3 inflammasome via targeting Sirtuin 1 (SIRT1)
样品类型: Serum - 文献: Reactive Oxygen Species Are Involved in the Development of Gastric Cancer and Gastric Cancer-Related Depression through ABL1-Mediated Inflammation Signaling Pathway
样品类型: blood - 文献: Neuroprotective Effects of Savinin on LPS-Induced Neuroinflammation In Vivo via Regulating MAPK/NF-κB Pathway and NLRP3 Inflammasome Activation
样品类型: Serum - 文献: Monkfish (Lophius litulon) Peptides Ameliorate High-Fat-Diet-Induced Nephrotoxicity by Reducing Oxidative Stress and Inflammation via Regulation of Intestinal Flora
样品类型: renal tissue - 文献: Design, Synthesis, and Anti-Inflammatory Activities of 12-Dehydropyxinol Derivatives
样品类型: RAW264.7 cell - 文献: The selective STING inhibitor H-151 preserves myocardial function and ameliorates cardiac fibrosis in murine myocardial infarction
样品类型: serum - 文献: Senescence marker protein 30 (SMP30) protects against high glucose-induced apoptosis, oxidative stress and inflammatory response in retinal ganglion cells by enhancing Nrf2 activation via regulation of Akt/GSK-3β pathway
样品类型: RGCs - 文献: Role of vitamin D/VDR nuclear translocation in down-regulation of NF-κB/NLRP3/caspase-1 axis in lupus nephritis
样品类型: serum,Mouse renal tubular epithelial cells (mRTECs) - 文献: RGFP966 is protective against lipopolysaccharide-induced depressive-like behaviors in mice by inhibiting neuroinflammation and microglial activation
样品类型: hippocampal tissue - 文献: Quercetin ameliorates Aspergillus fumigatus keratitis by inhibiting fungal growth, toll-like receptors and inflammatory cytokines
样品类型: Tissue homogenate(corneas) - 文献: Protective effect of combination of anakinra and MCC950 against acute lung injury is achieved through suppression of the NF-κB-mediated-MAPK and NLRP3-caspase pathways
样品类型: Tissue homogenate(lung),Bronchoalveolar Lavage Fluid - 文献: Oxymatrine inhibits neuroinflammation by Regulating M1/M2 polarization in N9 microglia through the TLR4/NF-κB pathway
样品类型: N9 microglial cell - 文献: New insights into the treatment mechanisms of Vitamin D on PM2.5-induced toxicity and inflammation in mouse renal tubular epithelial cells
样品类型: mRTECs - 文献: Inhibition of P2Y6 receptor expression in Kupffer cells alleviates alcoholic steatohepatitis in mice
样品类型: serum,RAW264.7 cell - 文献: High-density lipoprotein reduces microglia activation and protects against experimental autoimmune encephalomyelitis in mice
样品类型: plasma,BV2 microglial cell - 文献: Empagliflozin, a sodium glucose cotransporter-2 inhibitor, ameliorates peritoneal fibrosis via suppressing TGF-β/Smad signaling
样品类型: peritoneal dialysis solution,Cell culture supernatant - 文献: Disulfiram inhibits IL-1β secretion and inflammatory cells recruitment in Aspergillus fumigatus keratitis
样品类型: primary macrophage - 文献: COX-2-PGE2 signaling pathway contributes to hippocampal neuronal injury and cognitive impairment in PTZ-kindled epilepsy mice
样品类型: Tissue homogenate - 文献: Bixin protects mice against bronchial asthma though modulating PI3K/Akt pathway
样品类型: BALF - 文献: Atractyloside-A ameliorates spleen deficiency diarrhea by interfering with TLR4/MyD88/NF-κB signaling activation and regulating intestinal flora homeostasis
样品类型: colon tissue - 文献: Astragaloside IV ameliorates steroid-induced osteonecrosis of the femoral head by repolarizing the phenotype of pro-inflammatory macrophages
样品类型: Tissue homogenate - 文献: Artesunate attenuates atherosclerosis by inhibiting macrophage M1-like polarization and improving metabolism
样品类型: plasma - 文献: ACT001 suppressing M1 polarization against inflammation via NF-κB and STAT1 signaling pathways alleviates acute lung injury in mice
样品类型: BALF - 文献: Perillaldehyde: A promising antifungal agent to treat oropharyngeal candidiasis
样品类型: Tissue homogenate - 文献: Arsenic Trioxide in Synergy with Vitamin D Rescues the Defective VDR-PPAR- Functional Module of Autophagy in Rheumatoid Arthritis
样品类型: serum - 文献: CaMK4‐dependent phosphorylation of Akt/mTOR underlies Th17 excessive activation in experimental autoimmune prostatitis
样品类型: Cell culture supernatant,Tissue homogenate,serum - 文献: IL-37 alleviates Coxsackievirus B3-induced viral myocarditis via inhibiting NLRP3 inflammasome-mediated pyroptosis
样品类型: serum - 文献: lncRNA SNHG12 Inhibition Based on Microsystem Cell Imaging Technology Protects the Endothelium from LPS-Induced Inflammation by Inhibiting the Expression of miR-140-3p Target Gene fndc5
样品类型: BALF,PMVEC - 文献: Rhamnetin ameliorates macrophage-mediated inflammation and pro-atherosclerosis pathways in apolipoprotein E-deficient mice
样品类型: aorta - 文献: L-Carnitine Alleviates the Myocardial Infarction and Left Ventricular Remodeling through Bax/Bcl-2 Signal Pathway
样品类型: plasma - 文献: MiR-181-5p protects mice from sepsis via repressing HMGB1 in an experimental model
样品类型: Serum - 文献: Effect of β-casomorphin-7 on myocardial hypertrophy in hyperthyroidism-induced cardiomyopathy
样品类型: Serum,Tissue homogenate - 文献: Bexarotene Improve Depression-Like Behaviour in Mice by Protecting Against Neuro-inflammation and Synaptic Damage
样品类型: Tissue homogenate - 文献: Knockdown of PHLDA1 Alleviates Necrotizing Enterocolitis by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis Through Enhancing Nrf2 Signaling
样品类型: intestinal tissues - 文献: MMI-0100 Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice through Targeting MK2 Pathway
样品类型: colon - 文献: MMI-0100 Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice through Targeting MK2 Pathway
样品类型: colon - 文献: Design, Synthesis and Investigation of the Potential Anti-Inflammatory Activity of 7-O-Amide Hesperetin Derivatives
样品类型: Cell culture supernatant - 文献: Diosgenin glucoside protects against myocardial injury in diabetic mice by inhibiting RIP140 signaling
样品类型: serum,cardiac tissue - 文献: 6-Gingerol attenuates macrophages pyroptosis via the inhibition of MAPK signaling pathways and predicts a good prognosis in sepsis
样品类型: Cell culture supernatant - 文献: The preventive effect of low-dose aspirin in a PPAR-γ antagonist treated mouse model of preeclampsia
样品类型: plasma - 文献: β-arrestin2 Mediates the Arginine Vasopressin-Induced Expression of IL-1β in Murine Hearts
样品类型: serum,heart - 文献: Interaction of mannose binding lectin and other pattern recognition receptors in human corneal epithelial cells during Aspergillus fumigatus infection
样品类型: Tissue homogenate - 文献: B-cell-specific mammalian target of rapamycin complex 1 activation results in severe osteoarthritis in mice
样品类型: serum - 文献: Anti-Nociceptive and Anti-Inflammatory Activities of the Ethyl Acetate Extract of Belamcanda chinensis (L.) Redouté in Raw 264.7 Cells in vitro and Mouse Model in vivo
样品类型: RAW264.7 cell - 文献: Exosomes derived from synovial fibroblasts under hypoxia aggravate rheumatoid arthritis by regulating Treg/Th17 balance:
样品类型: Cell culture medium - 文献: Repression of Toll-like receptor-4 by microRNA-149-3p is associated with smoking-related COPD
样品类型: Cell culture supernatant - 文献: The protective effects of Chinese yam polysaccharide against obesity-induced insulin resistance
样品类型: Serum - 文献: Anti-fatigue activity of purified anthocyanins prepared from purple passion fruit (P. edulis Sim) epicarp in mice
样品类型: Tissue homogenate - 文献: Role of Interleukin-17 in Pathogenesis of Intestinal Fibrosis in Mice
样品类型: blood - 文献: miR-128-3p Inhibits NRP1 Expression and Promotes Inflammatory Response to Acute Kidney Injury in Sepsis
样品类型: TCMK-1 cell - 文献: Osthole prevents acetaminophen-induced liver injury in mice
样品类型: Tissue homogenate - 文献: Molecular mechanisms of the analgesic action of Wu-tou Decoction on neuropathic pain in mice revealed using microarray and network analysis
样品类型: Tissue homogenate - 文献: Diet-Derived Advanced Glycation End Products (dAGEs) Induce Proinflammatory Cytokine Expression in Cardiac and Renal Tissues of Experimental Mice: Protective Effect of Curcumin
样品类型: serum - 文献: Saffron extract attenuates neuroinflammation in rmTBI mouse model by suppressing NLRP3 inflammasome activation via SIRT1
样品类型: brain - 文献: Blockade of high mobility group box 1 involved in the protective of curcumin on myocardial injury in diabetes in vivo and in vitro
样品类型: Serum - 文献: Pancreastatin inhibitor PSTi8 protects the obesity associated skeletal muscle insulin resistance in diet induced streptozotocin-treated diabetic mice
样品类型: plasma - 文献: A Herbal Mixture from Propolis, Pomegranate, and Grape Pomace Endowed with Anti-Inflammatory Activity in an In Vivo Rheumatoid Arthritis Model
样品类型: serum - 文献: The protective effects of S14G-humanin (HNG) against mono-sodium urate (MSU) crystals- induced gouty arthritis
样品类型: BMDMs - 文献: The protective effects of Pimavanserin against cerebral ischemia-induced brain injury
样品类型: brain tissue - 文献: Synergetic protective effect of berberine and ginsenoside Rb1 against tumor necrosis factor alpha−induced inflammation in adipocytes
样品类型: 3T3-L1 preadipocyte - 文献: Shikonin combined with methotrexate regulate macrophage polarization to treat psoriasis
样品类型: RAW264.7 cell - 文献: Protective effect of dexmedetomidine in cecal ligation perforation-induced acute lung injury through HMGB1/RAGE pathway regulation and pyroptosis activation
样品类型: bronchoalveolar lavage fluid (BALF) - 文献: Guizhi Fuling pill attenuates liver fibrosis in vitro and in vivo via inhibiting TGF-β1/Smad2/3 and activating IFN-γ/Smad7 signaling pathways
样品类型: liver tissue - 文献: Blocking the CD38/cADPR pathway plays a double-edged role in LPS stimulated microglia
样品类型: Cell culture supernatant - 文献: Anti-inflammatory effect of a novel synthetic compound 1-((4-fluorophenyl)thio)isoquinoline in RAW264.7 macrophages and a zebrafish model
样品类型: Cell culture supernatant - 文献: MicroRNA-27a alleviates LPS-induced acute lung injury in mice via inhibiting inflammation and apoptosis through modulating TLR4/MyD88/NF-κB pathway
样品类型: bronchoalveolar lavage fluid (BALF),RAW 264.7 cells - 文献: The Elastin-Derived Peptide VGVAPG Does Not Activate the Inflammatory Process in Mouse Cortical Astrocytes In Vitro
样品类型: mouse astrocyte cell - 文献: Regulation of CD39 expression in ATP-P2Y2R-mediated alcoholic liver steatosis and inflammation
样品类型: Serum,Cell culture supernatant - 文献: Icariin targets Nrf2 signaling to inhibit microglia-mediated neuroinflammation
样品类型: primary microglia,BV2 cells - 文献: Tetrahydroxy stilbene glucoside alleviates palmitic acid-induced inflammation and apoptosis in cardiomyocytes by regulating miR-129-3p/Smad3 signaling
样品类型: Cell culture supernatant - 文献: Honokiol alleviates sepsis-induced acute kidney injury in mice by targeting the miR-218-5p/heme oxygenase-1 signaling pathway
样品类型: Serum - 文献: Biological evaluation of naturally occurring bulbocodin D as a potential multi-target agent for Alzheimer’s disease
样品类型: Cell culture supernatant - 文献: Overexpression of lncRNA Gm43050 alleviates apoptosis and inflammation response induced by sevoflurane treatment by regulating miR-640/ZFP91
样品类型: primary hippocampal neurons - 文献: Development, optimisation and evaluation of chitosan nanoparticles of alendronate against Alzheimer’s disease in intracerebroventricular streptozotocin model for brain delivery
样品类型: Tissue homogenate - 文献: iTRAQ-based proteomics and in vitro experiments reveals essential roles of ACE and AP-N in the renin–angiotensin system-mediated congenital ureteropelvic junction obstruction
样品类型: Serum,Cell sample - 文献: Portulaca Extract Attenuates Development of Dextran Sulfate Sodium Induced Colitis in Mice through Activation of PPARγ
样品类型: serum - 文献: Lidocaine relieves spinal cord ischemia-reperfusion injury via long non-coding RNA MIAT-mediated Notch1 downregulation
样品类型: serum,BV2 cell - 文献: Aspergillus fumigatus Increased PAR-2 Expression and Elevated Proinflammatory Cytokines Expression Through the Pathway of PAR-2/ERK1/2 in Cornea
样品类型: Tissue homogenate - 文献: Suppressive Effects of Gelsemine on Anxiety-like Behaviors Induced by Chronic Unpredictable Mild Stress in Mice
样品类型: brain tissue - 文献: Curcumin amends Ca 2+ dysregulation in microglia by suppressing the activation of P2X7 receptor
样品类型: brain,serum - 文献: MiR-340-5p alleviates neuroinflammation and neuronal injury via suppressing STING in subarachnoid hemorrhage
样品类型: brain tissue,microglia - 文献: VX765, a Specific Caspase-1 Inhibitor, Alleviates Lung Ischemia Reperfusion Injury by Suppressing Endothelial Pyroptosis and Barrier Dysfunction
样品类型: lung tissue,serum,PMVEC - 文献: Protective Effect of Luteolin on D-Galactosamine (D-Gal)/Lipopolysaccharide (LPS) Induced Hepatic Injury by in Mice
样品类型: serum,liver - 文献: Effect and Mechanism of Mycobacterium tuberculosis Lipoprotein LpqH in NLRP3 Inflammasome Activation in Mouse Ana-1 Macrophage
样品类型: Cell supernatant - 文献: Attractylone attenuates sepsis‐associated encephalopathy and cognitive dysfunction by inhibiting microglial activation and neuroinflammation
样品类型: Cell culture supernatant,Tissue homogenate - 文献: The protective effect of formononetin on cognitive impairment in streptozotocin (STZ)-induced diabetic mice
样品类型: Serum,Tissue homogenate - 文献: Honokiol Reduces Fungal Load, Toll-Like Receptor-2, and Inflammatory Cytokines in Aspergillus fumigatus Keratitis
样品类型: Cell culture supernatant - 文献: Curcumin prevents osteocyte apoptosis by inhibiting M1‐type macrophage polarization in mice model of glucocorticoid‐associated osteonecrosis of the femoral head
样品类型: peripheral blood - 文献: (3α)-3-(tiglinoyloxy)-ent-kaur-16-en-19-oic acid, isolated from Wedelia trilobata L., exerts an anti-inflammatory effect via the modulation of NF-κB, MAPK and mTOR pathway and autophagy in LPS-stimulated macrophages
样品类型: Cell culture supernatant - 文献: NLRP6 Induces Lung Injury and Inflammation Early in Brucella and Influenza Coinfection
样品类型: lung tissues - 文献: Effects of Different Radiation Sources on the Performance of Collagen-Based Corneal Repair Materials and Macrophage Polarization
样品类型: RAW264.7 macrophages - 文献: Curcumin Reduces Cognitive Deficits by Inhibiting Neuroinflammation through the Endoplasmic Reticulum Stress Pathway in Apolipoprotein E4 Transgenic Mice
样品类型: Tissue homogenate(Brain) - 文献: Verapamil Ameliorates Hepatic Metaflammation by Inhibiting Thioredoxin-Interacting Protein/NLRP3 Pathways
样品类型: Serum - 文献: Dendrobium Nobile Lindl Polysaccharides Attenuate UVB-Induced Photodamage by Regulating Oxidative Stress, Inflammation and Mmps Expression in Mice Model
样品类型: skin - 文献: The modulatory impacts of Glycyrrhiza glabra extract against methotrexate-induced testicular dysfunction and oxidative stress
样品类型: serum - 文献: Upregulated galectin-3 is not a critical disease mediator of cardiomyopathy induced by β2-adrenoceptor overexpression
样品类型: left ventricle (LV) tissues - 文献: Methamphetamine induced neuroinflammation in mouse brain and microglial cell line BV2: Roles of the TLR4/TRIF/Peli1 signaling axis
样品类型: Cell culture supernatant,Tissue homogenate - 文献: Sulforaphane protects myocardium from ischemia-reperfusion injury by regulating CaMKIIN2 and CaMKIIδ
样品类型: H9c2 cell - 文献: Loss of serine/threonine protein kinase 25 in retinal ganglion cells ameliorates high glucose-elicited damage through regulation of the AKT-GSK-3β/Nrf2 pathway
样品类型: retina ganglion cell - 文献: Pharmacological Postconditioning by Protocatechuic Acid Attenuates Brain Injury in Ischemia–Reperfusion (I/R) Mice Model: Implications of Nuclear Factor Erythroid-2-Related Factor Pathway
样品类型: brain - 文献: NLRP3 inflammasome up-regulates major histocompatibility complex class I expression and promotes inflammatory infiltration in polymyositis
样品类型: Raw 264.7 cell - 文献: SIRT1 activation by butein attenuates sepsis-induced brain injury in mice subjected to cecal ligation and puncture via alleviating inflammatory and oxidative stress
样品类型: Serum,Tissue homogenate - 文献: Effects of taraxasterol against ethanol and high-fat diet-induced liver injury by regulating TLR4/MyD88/NF-κB and Nrf2/HO-1 signaling pathways
样品类型: Serum - 文献: DHCR24 overexpression modulates microglia polarization and inflammatory response via Akt/GSK3β signaling in Aβ25–35 treated BV-2 cells
样品类型: Cell sample - 文献: Viphyllin™, a standardized extract from black pepper seeds, mitigates intestinal inflammation, oxidative stress, and anxiety-like behavior in DSS-induced colitis mice
样品类型: colon tissue - 文献: Exploring the potential of Lacticaseibacillus paracasei M11 on antidiabetic, anti-inflammatory, and ACE inhibitory effects of fermented dromedary camel milk (Camelus dromedaries) and the release of antidiabetic and anti-hypertensive peptides
样品类型: RAW 264.7 cells - 文献: CDGSH iron sulfur domain 2 mitigates apoptosis, oxidative stress and inflammatory response caused by oxygen–glucose deprivation/reoxygenation in HT22 hippocampal neurons by Akt-Nrf2-activated pathway
样品类型: HT22 neurons - 文献: Artesunate alleviates intracerebral hemorrhage secondary injury by inducing ferroptosis in M1-polarized microglia and suppressing inflammation through AMPK/mTORC1/GPX4 pathway
样品类型: brain tissues - 文献: Comparison of the structural characteristics and immunostimulatory activities of polysaccharides from wild and cultivated Pleurotus feruleus
样品类型: serum - 文献: The osteoimmunomodulatory effect of nanostructured TiF
x
/TiO
x
coating on osteogenesis induction
样品类型: RAW264.7 cells - 文献: IGF2 inhibits hippocampal over-activated microglia and alleviates depression-like behavior in LPS- treated male mice
样品类型: Serum - 文献: Acetaldehyde dehydrogenase 2 activation attenuates sepsis-induced brain injury through NLRP3 inflammasome regulation
样品类型: HT22 cell - 文献: Sodium P-aminosalicylic Acid Attenuates Manganese-Induced Neuroinflammation in BV2 Microglia by Modulating NF-κB Pathway
样品类型: Cell culture supernatant(BV2 Cells) - 文献: Borate Ameliorates Sodium Nitrite-Induced Oxidative Stress Through Regulation of Oxidant/Antioxidant Status: Involvement of the Nrf2/HO-1 and NF-κB Pathways
样品类型: Serum - 文献: Pepsin-Soluble Collagen from the Skin of Lophius litulo: A Preliminary Study Evaluating Physicochemical, Antioxidant, and Wound Healing Properties
样品类型: serum - 文献: In vitro and in vivo biocompatibility study of surface modified TiN deposited on Ti6Al4V using high-power impulse magnetron sputtering technique
样品类型: skin - 文献: Hesperidin alleviates chronic restraint stress and lipopolysaccharide-induced Hippocampus and Frontal cortex damage in mice: Role of TLR4/NF-κB, p38 MAPK/JNK, Nrf2/ARE signaling
样品类型: Serum - 文献: Effects of different doses of omega-3 polyunsaturated fatty acids on gut microbiota and immunity
样品类型: serum - 文献: Adiponectin Inhibits NLRP3 Inflammasome Activation in Nonalcoholic Steatohepatitis via AMPK-JNK/ErK1/2-NFκB/ROS Signaling Pathways
样品类型: Tissue homogenate(liver tissue) - 文献: Blocking PI3K/AKT signaling inhibits bone sclerosis in subchondral bone and attenuates post‐traumatic osteoarthritis
样品类型: serum,preosteoblasts - 文献: Assessment of novel azaanthraquinone derivatives as potent multi-target inhibitors of inflammation and amyloid-β aggregation in Alzheimer’s disease
样品类型: Cell culture medium - 文献: Saikosaponin-d attenuated lipopolysaccharide-induced depressive-like behaviors via inhibiting microglia activation and neuroinflammation
样品类型: Cell sample,Tissue homogenate - 文献: NLRP12 negatively regulates EtOH-induced liver macrophage activation via NF-κB pathway and mediates hepatocyte apoptosis in alcoholic liver injury
样品类型: serum,RAW 264.7 cell - 文献: Myricitrin pretreatment ameliorates mouse liver ischemia reperfusion injury
样品类型: Serum - 文献: miR-129-5p alleviates LPS-induced acute kidney injury via targeting HMGB1/TLRs/NF-kappaB pathway
样品类型: Serum - 文献: Inhibition of LOX-1 prevents inflammation and photoreceptor cell death in retinal degeneration
样品类型: Cell culture supernatant - 文献: Inhibition of HMGB1 involved in the protective of salidroside on liver injury in diabetes mice
样品类型: Cell culture supernatant,Serum,Tissue homogenate - 文献: Didymin ameliorates dexamethasone-induced non-alcoholic fatty liver disease by inhibiting TLR4/NF-κB and PI3K/Akt pathways in C57BL/6J mice
样品类型: Tissue homogenate - 文献: Betulin alleviates on myocardial inflammation in diabetes mice via regulating Siti1/NLRP3/NF-κB pathway
样品类型: serum,heart - 文献: 4-hydroxybenzo[d]oxazol-2(3H)-one ameliorates LPS/D-GalN-induced acute liver injury by inhibiting TLR4/NF-κB and MAPK signaling pathways in mice
样品类型: Tissue homogenate - 文献: Platinum nanoparticles Protect Against Lipopolysaccharide-Induced Inflammation in Microglial BV-2 Cells via Decreased Oxidative Damage and Increased Phagocytosis
样品类型: BV-2 cell - 文献: Latexin deficiency in mice up-regulates inflammation and aggravates colitis through HECTD1/Rps3/NF-κB pathway
样品类型: Serum - 文献: Effects of Pulsed Electromagnetic Field Therapy at Different Frequencies on Bone Mass and Microarchitecture in Osteoporotic Mice
样品类型: serum - 文献: Hybrids of oxoisoaporphine–tetrahydroisoquinoline: novel multi-target inhibitors of inflammation and amyloid-β aggregation in Alzheimer’s disease
样品类型: Cell culture medium - 文献: Integrating Network Pharmacology and Component Analysis Study on Anti-Atherosclerotic Mechanisms of Total Flavonoids of Engelhardia roxburghiana Leaves in Mice
样品类型: Thoracic aortas - 文献: Role of Brd4 in the production of inflammatory cytokines in mouse macrophages treated with titanium particles
样品类型: Cell culture supernatant - 文献: Antihypernociceptive and neuroprotective effects of Combretin A and Combretin B on streptozotocin-induced diabetic neuropathy in mice
样品类型: Serum,Spinal cord - 文献: Coenzyme Q10 alleviates sevoflurane‑induced neuroinflammation by regulating the levels of apolipoprotein E and phosphorylated tau protein in mouse hippocampal neurons
样品类型: Tissue homogenate - 文献: Lipofundin Mediates the Major Inhibition of Intravenous Propofol in IL‐1β Secretion and Phagocytosis of Staphylococcus aureus‐Infected Macrophages
样品类型: Cell culture medium - 文献: Atrial Natriuretic Peptide (ANP) Suppress λ-Carrageenan-Induced Acute Paw Edema by Modulating Pro-inflammatory Genes in Swiss Albino Mice
样品类型: paw tissue - 文献: Frequent exposure to varied home cage sizes alters pain sensitivity and some key inflammation-related biomarkers
样品类型: Tissue homogenate - 文献: FSC231 can alleviate paclitaxel-induced neuralgia by inhibiting PICK1 and affecting related factors
样品类型: Tissue homogenate - 文献: miR-1929-3p Overexpression Alleviates Murine Cytomegalovirus-Induced Hypertensive Myocardial Remodeling by Suppressing Ednra/NLRP3 Inflammasome Activation
样品类型: serum,heart - 文献: Ghrelin ameliorates intestinal barrier dysfunction in experimental colitis by inhibiting the activation of nuclear factor-kappa B
样品类型: Tissue homogenate - 文献: Death-associated protein kinase 1 correlates with podocyte apoptosis and renal damage and can be mediated by miR-361.
样品类型: renal podocytes - 文献: Aerobic exercise alleviates ventilator-induced lung injury by inhibiting NLRP3 inflammasome activation
样品类型: lung tissues - 文献: The immunostimulatory activity of polysaccharides from Glycyrrhiza uralensis
样品类型: Tissue homogenate - 文献: Effect and mechanism of citral against methicillin‐resistant Staphylococcus aureus in vivo
样品类型: Serum - 文献: Knockout of MD1 contributes to sympathetic hyperactivity and exacerbates ventricular arrhythmias following heart failure with preserved ejection fraction via NLRP3 inflammasome activation
样品类型: Tissue homogenate - 文献: HMGB1 augments cognitive impairment in sepsis-associated encephalopathy by binding to MD-2 and promoting NLRP3-induced neuroinflammation
样品类型: brain,serum - 文献: Gentiopicroside abrogates lipopolysaccharide-induced depressive-like behavior in mice through tryptophan-degrading pathway
样品类型: Plasma - 文献: LincRNA‑EPS increases TGF‑β expression to inhibit the Wnt/β‑catenin pathway, VSMC osteoblastic differentiation and vascular calcification in diabetic mice
样品类型: serum - 文献: Effects of sepsis on the metabolism of sphingomyelin and cholesterol in mice with liver dysfunction
样品类型: Plasma - 文献: Clostridium butyricum protects intestinal barrier function via upregulation of tight junction proteins and activation of the Akt/mTOR signaling pathway in a mouse model of dextran sodium sulfate‑induced colitis
样品类型: Serum - 文献: MiR-223-3p and miR-22-3p inhibit monosodium urate-induced gouty inflammation by targeting NLRP3
样品类型: Tissue homogenate(air pouch) - 文献: Upregulation of BRD7 protects podocytes against high glucose-induced apoptosis by enhancing Nrf2 in a GSK-3β-dependent manner
样品类型: MPC-5 cell - 文献: Isolation, characterization and anti-inflammatory mechanism of probiotics in lipopolysaccharide-stimulated RAW 264.7 macrophages
样品类型: RAW 264.7 cell - 文献: -infected RAW264.7 cells
样品类型: cell - 文献: Bushen Huoxue Acupuncture Inhibits NLRP1 Inflammasome-Mediated Neuronal Pyroptosis in SAMP8 Mouse Model of Alzheimer’s Disease
样品类型: Cell lysate - 文献: Upregulated TSG-6 Expression in ADSCs Inhibits the BV2 Microglia-Mediated Inflammatory Response
样品类型: BV2 cells - 文献: Activation of Paraventricular Melatonin Receptor 2 Mediates Melatonin-Conferred Cardioprotection Against Myocardial Ischemia/Reperfusion Injury
样品类型: PVN tissue - 文献: Camelina sativa Oil Treatment Alleviates Castor Oil-Induced Diarrhea in ICR Mice by Regulating Intestinal Flora Composition
样品类型: plasma - 文献: Biejiajian Pill Ameliorates Diabetes-Associated Atherosclerosis through Inhibition of the NLRP3 Inflammasome
样品类型: serum - 文献: Sodium P-aminosalicylic Acid Inhibits Manganese-Induced Neuroinflammation in BV2 Microglial Cells via NLRP3-CASP1 Inflammasome Pathway
样品类型: Cell sample - 文献: IL-37 alleviates alveolar bone resorption and inflammatory response through the NF-κB/NLRP3 signaling pathway in male mice with periodontitis
样品类型: periodontal tissue - 文献: Downregulating Gasdermin D Reduces Severe Acute Pancreatitis Associated with Pyroptosis
样品类型: Serum - 文献: Fu Fang Zhen Zhu Tiao Zhi Capsules Protect against Myocardial Ischemia by Inhibiting Cardiomyocyte Pyroptosis.
样品类型: serum,cardiomyocyte - 文献: Exploring the Muscle Metabolomics in the Mouse Model of Sepsis-Induced Acquired Weakness
样品类型: serum - 文献: Anti-inflammatory Mechanism of Action of Benzoylmesaconine in Lipopolysaccharide-Stimulated RAW264.7 Cells
样品类型: RAW264.7 cell - 文献: Chrysosplenol D protects mice against LPS-induced acute lung injury by inhibiting oxidative stress, inflammation, and apoptosis via TLR4-MAPKs/NF-κB signaling pathways:
样品类型: Bronchoalveolar Lavage Fluid - 文献: Corilagin potential in inhibiting oxidative and inflammatory stress in LPS-induced murine macrophage cell lines (RAW 264.7)
样品类型: RAW 264.7 cell - 文献: The effect of maternal obesity on the expression and functionality of placental P-glycoprotein: Implications in the individualized transplacental digoxin treatment for fetal heart failure
样品类型: Plasma - 文献: Impact of Thymus vulgaris extract on sodium nitrite-induced alteration of renal redox and oxidative stress: Biochemical, molecular, and immunohistochemical study
样品类型: Serum,Tissue homogenate(kidney) - 文献: Broccoli microgreens have hypoglycemic effect by improving blood lipid and inflammatory factors while modulating gut microbiota in mice with type 2 diabetes
样品类型: serum - 文献: The Berberis vulgaris L. extract berberine exerts its anti-oxidant effects to ameliorate cholesterol overloading–induced cell apoptosis in the primary mice hepatocytes: an in vitro study
样品类型: serum - 文献: Hace1 overexpression mitigates myocardial hypoxia/reoxygenation injury via the effects on Keap1/Nrf2 pathway
样品类型: Primary cardiac cells - 文献: Protective effects of endotoxin tolerance on peripheral lipopolysaccharide-induced neuroinflammation and dopaminergic neuronal injury
样品类型: substantia nigra (SN) - 文献: Liraglutide attenuates lipopolysaccharide-induced acute lung injury in mice
样品类型: Bronchoalveolar Lavage Fluid - 文献: hnRNPK knockdown alleviates NLRP3 inflammasome priming by repressing FLIP expression in Raw264.7 macrophages
样品类型: Cell culture supernatant - 文献: Formononetin Ameliorates Cognitive Disorder via PGC-1α Pathway in Neuroinflammation Conditions in High-Fat Diet-Induced Mice
样品类型: hippocampus - 文献: Phytochemical, Cytotoxicity, Antioxidant and Anti-Inflammatory Effects of Psilocybe Natalensis Magic Mushroom
样品类型: Cell culture supernatant - 文献: miR-124/MCP-1 signaling pathway modulates the protective effect of itraconazole on acute kidney injury in a mouse model of disseminated candidiasis
样品类型: serum - 文献: Shen-ling-bai-zhu-san ameliorates inflammation and lung injury by increasing the gut microbiota in the murine model of Streptococcus pneumonia-induced pneumonia.
样品类型: Tissue homogenate - 文献: Isomangiferin Attenuates Renal Injury in Diabetic Mice via Inhibiting Inflammation
样品类型: Serum,Tissue homogenate - 文献: Capparis spinosa Fruit Ethanol Extracts Exert Different Effects on the Maturation of Dendritic Cells
样品类型: Cell culture supernatant - 文献: MiR-590-3p Attenuates Acute Kidney Injury by Inhibiting Tumor Necrosis Factor Receptor-Associated Factor 6 in Septic Mice
样品类型: Serum - 文献: Ablation of GSDMD Improves Outcome of Ischemic Stroke Through Blocking Canonical and Non-canonical Inflammasomes Dependent Pyroptosis in Microglia
样品类型: BV2 cell - 文献: Neurotoxic 18-kDa apolipoprotein E fragment production contributes to anesthetic sevoflurane-induced tau phosphorylation and neuroinflammation in vitro:
样品类型: neurons - 文献: Exposure time determines the protective effect of Trichinella spiralis on experimental colitis
样品类型: Serum - 文献: Establishment and Mechanism Study of a Primary Ovarian Insufficiency Mouse Model Using Lipopolysaccharide
样品类型: serum - 文献: Sinomenine Attenuates Cartilage Degeneration by Regulating miR-223-3p/NLRP3 Inflammasome Signaling
样品类型: Serum,Cell culture supernatant - 文献: Atractylon treatment prevents sleep-disordered breathing-induced cognitive dysfunction by suppression of chronic intermittent hypoxia-induced M1 microglial activation
样品类型: Cell culture supernatant - 文献: α‑rhamnrtin‑3‑α‑rhamnoside exerts anti‑inflammatory effects on lipopolysaccharide‑stimulated RAW264.7 cells by abrogating NF‑κB and activating the Nrf2 signaling pathway
样品类型: RAW264.7 cell - 文献: Gastrodin attenuates neuroinflammation in DOI‐induce Tourette syndrome in rats
样品类型: Serum,Tissue homogenate - 文献: Gastrodin alleviates Tourette syndrome via Nrf‐2/HO‐1/HMGB1/NF‐кB pathway
样品类型: Tissue homogenate - 文献: Expression and role of calcitonin gene-related peptide in mouse Aspergillus fumigatus keratitis
样品类型: Cell culture supernatant - 文献: Gentiopicroside protects neurons from astrocyte-mediated inflammatory injuries by inhibition of nuclear factor-κB and mitogen-activated protein kinase signaling pathways
样品类型: Cell culture supernatant - 文献: Gallincin ameliorates colitis-associated inflammation and barrier function in mice based on network pharmacology prediction:
样品类型: homogenized colonic tissue - 文献: Anti-inflammatory effects of astaxanthin against fungal keratitis
样品类型: Tissue homogenate(Corneas) - 文献: miR‑148a inhibits pro‑inflammatory cytokines released by intervertebral disc cells by regulating the p38/MAPK pathway
样品类型: Cell culture supernatant - 文献: NLRP3 inflammasome signaling as an early molecular response is negatively controlled by miR-186 in CFA-induced prosopalgia mice
样品类型: Serum,Tissue homogenate - 文献: LncRNA TUG1 reverses LPS-induced cell apoptosis and inflammation of macrophage via targeting MiR-221-3p/SPRED2 axis
样品类型: Tissue homogenate - 文献: Chemerin-9 Peptide Enhances Memory and Ameliorates Aβ1-42-induced Object Memory Impairment in Mice
样品类型: hippocampus - 文献: The association between inflammation, the microbiome and urethane-induced pulmonary adenocarcinoma Corrigendum in /10.3892/ol.2018.9063
样品类型: Serum - 文献: Impact of Lesinurad and allopurinol on experimental Hyperuricemia in mice: biochemical, molecular and Immunohistochemical study
样品类型: Serum - 文献: Subcutaneous administration of casein attenuates atherosclerotic progression in male apoE-/- mice fed with high-fat diet
样品类型: Plasma - 文献: Antioxidant and Anti-Inflammatory Activities of Kigelia africana (Lam.) Benth.
样品类型: RAW 264.7 cell - 文献: Synergistic protection of matrine and lycopene against lipopolysaccharide‑induced acute lung injury in mice
样品类型: lung - 文献: Kisspeptin‑13 inhibits bleomycin‑induced pulmonary fibrosis through GPR54 in mice
样品类型: lung - 文献: Kisspeptin‑13 inhibits bleomycin‑induced pulmonary fibrosis through GPR54 in mice
样品类型: lung - 文献: Oral supplementation with ursolic acid ameliorates sepsis-induced acute kidney injury in a mouse model by inhibiting oxidative stress and inflammatory responses
样品类型: Serum - 文献: Embelin inhibits abdominal aortic aneurysm through decreasing IL‑6‑induced STAT3 and NF‑κB inactivation
样品类型: Aortic tissues - 文献: Dioscin prevents LPS‑induced acute lung injury through inhibiting the TLR4/MyD88 signaling pathway via upregulation of HSP70
样品类型: Serum,Tissue homogenate - 文献: Protective effects on acute hypoxic-ischemic brain damage in mfat-1 transgenic mice by alleviating neuroinflammation
样品类型: brain tissue - 文献: Antihypernociceptive, Anxiolytic, and Antidepressant Properties of Aqueous and Ethanol Extracts of Dissotis thollonii Cogn. (Melastomataceae) in Mice
样品类型: Serum,Tissue homogenate - 文献: Anti-hypernociceptive effects of methanol extract of Boswellia dalzielii on STZ-induced diabetic neuropathic pain
样品类型: serum,sciatic nerves - 文献: Effect of ganoderic acid on diethylnitrosamine-induced liver cancer in mice
样品类型: serum - 文献: Antioxidant and anti-inflammatory effects of an ethanol fraction from the Schisandra chinensis baillon hot water extract fermented using Lactobacilius paracasei subsp. tolerans
样品类型: RAW 264.7 cells - 文献: A Comparative Study of the Effects upon LPS Induced Macrophage RAW264.7 Inflammation in vitro of the Lipids of Hippocampus trimaculatus Leach
样品类型: Cell culture supernatant
