Mouse IL-6(Interleukin 6) ELISA Kit
小鼠白介素6(IL-6)酶联免疫吸附测定试剂盒
| 规格： | / 96T / 48T / 96T*5 |
| 价格： | / ￥2400 / ￥1650 / ￥10200 |
货号：E-EL-M0044
反应性: 小鼠
检测范围: 31.25~2000 pg/mL
灵敏度: 18.75 pg/mL
用途
该试剂盒用于体外定量检测小鼠serum, plasma and other biological fluids中IL-6浓度
检测原理
本试剂盒采用双抗体夹心ELISA法。用抗小鼠IL-6抗体包被于酶标板上，实验时样品或标准品中的小鼠IL-6会与包被抗体结合，游离的成分被洗去。依次加入生物素化的抗小鼠IL-6抗体和辣根过氧化物酶标记的亲和素。抗小鼠IL-6抗体与结合在包被抗体上的小鼠IL-6结合、生物素与亲和素特异性结合而形成免疫复合物，游离的成分被洗去。加入显色底物(TMB)，TMB在辣根过氧化物酶的催化下呈现蓝色，加终止液后变成黄色。用酶标仪在450nm波长处测OD值，IL-6浓度与OD450值之间呈正比，通过绘制标准曲线计算出样品中IL-6的浓度。
| 反应类型 | 夹心法 |
| 规格 | 96T |
| 反应时间 | 3.5h |
| 反应性 | 小鼠 |
| 检测方法 | Colormetric |
| 检测范围 | 31.25—2000 pg/mL |
| 灵敏度 | 18.75 pg/mL |
| 样本体积 | 100μL |
| 样本类型 | serum, plasma and other biological fluids |
特异性
可检测样本中的小鼠IL-6，且与其它相关蛋白无明显交叉反应。
重复性
板内，板间变异系数均<10%。
典型数据
由于实验操作条件的不同（如操作者、移液技术、洗板技术和稳定条件等），标准曲线的OD值会有所差异。以下数据和曲线仅供参考，实验者需根据自己的实验建立标准曲线。
| (pg/mL) | O.D | Average | Corrected |
|---|---|---|---|
| 2000 | 2.471 2.503 |
2.487 | 2.427 |
| 1000 | 1.682 1.72 |
1.701 | 1.641 |
| 500 | 0.945 0.915 |
0.93 | 0.87 |
| 250 | 0.421 0.441 |
0.431 | 0.371 |
| 125 | 0.267 0.243 |
0.255 | 0.195 |
| 62.5 | 0.17 0.154 |
0.162 | 0.102 |
| 31.25 | 0.109 0.115 |
0.112 | 0.052 |
| 0 | 0.05 0.070 |
0.06 | -- |
精密度
板内精密度:低浓度样本,中浓度样本和高浓度样本分别在1块板子上检测20次。
板间精密度:低浓度样本,中浓度样本和高浓度样本分别在3块板子上检测20次。
| Intra-assay Precision | Inter-assay Precision | |||||
|---|---|---|---|---|---|---|
| Sample | 1 | 2 | 3 | 1 | 2 | 3 |
| n | 20 | 20 | 20 | 20 | 20 | 20 |
| Mean (pg/mL) |
99.40 | 174.50 | 952.80 | 105.30 | 162.70 | 1040.70 |
| Standard
deviation |
6.40 | 7.70 | 50.50 | 6.50 | 8.10 | 38.50 |
| C V (%) | 6.44 | 4.41 | 5.30 | 6.17 | 4.98 | 3.70 |
回收率
分别往5个不同样本中添加已知浓度的目标蛋白，做回收实验，得出回收率范围和平均回收率。
| Sample Type | Range (%) | Average Recovery (%) |
|---|---|---|
| Serum (n=5) | 86-100 | 93 |
| EDTA plasma (n=5) | 88-101 | 94 |
| Cell culture media (n=5) | 89-104 | 95 |
线性
分别往5个样本中添加已知浓度的目标蛋白，做回收实验，得出回收率范围及平均回收率。将5个样本分别稀释2倍，4倍，8倍，16倍做回收实验，得出回收率范围及平均回收率。
| Serum (n=5) | EDTA plasma (n=5) | Cell culture media (n=5) | ||
|---|---|---|---|---|
| 1:2 | Range (%) | 91-106 | 91-103 | 98-111 |
| Average (%) | 98 | 98 | 104 | |
| 1:4 | Range (%) | 94-109 | 88-103 | 98-110 |
| Average (%) | 100 | 94 | 104 | |
| 1:8 | Range (%) | 94-108 | 87-98 | 95-106 |
| Average (%) | 101 | 93 | 100 | |
| 1:16 | Range (%) | 97-113 | 84-97 | 97-109 |
| Average (%) | 105 | 91 | 103 |
试剂盒组成及保存
未拆封的试剂盒可在4℃保存一周；如果一周以后才使用试剂盒，请拆开试剂盒按照下表中的条件分别保存各组分。
| 中文名称 | 英文名称 | 规格 | 保存条件 |
|---|---|---|---|
| ELISA酶标板(可拆卸) | Micro ELISA Plate(Dismountable) | 8 孔×12 条 | -20℃，可存放6个月 |
| 冻干标准品 | Reference Standard | 2 支 | |
| 浓缩生物素化抗体(100×) | Concentrated Biotinylated Detection Ab | 1支 120 μL | |
| 浓缩HRP酶结合物(100×) | Concentrated HRP Conjugate | 1支 120 μL | -20℃(避光)，可存放6个月 |
| 标准品&样品稀释液 | Reference Standard & Sample Diluent | 1瓶 20 mL | 4℃.可存放6个月 |
| 生物素化抗体稀释液 | Biotinylated Detection Ab Diluent | 1瓶 14 mL | |
| 酶结合物稀释液 | HRP Conjugate Diluent | 1瓶 14 mL | |
| 浓缩洗涤液(25×) | Concentrated Wash Buffer (25×) | 1瓶 30 mL | |
| 底物溶液(TMB) | Substrate Reagent | 1瓶 10 mL | 4℃(避光) |
| 反应终止液 | Stop Solution | 1瓶 10 mL | 4℃ |
| 封板覆膜 | Plate Sealer | 5 张 | |
| 产品说明书 | Product Description | 1 份 | |
| 质检报告 | Certificate of Analysis | 1 份 |
说明：所有试剂瓶盖须旋紧以防止蒸发和微生物的污染。
试剂体积以实际发货版说明书为准。相关试剂在分装时会比标签上标明的体积稍多一些，请在使用时量取而非直接倒出。
试验所需自备物品
- 1. 酶标仪(450nm波长滤光片)
- 2. 高精度移液器，EP管及一次性吸头：0.5-10 μL, 2-20 μL, 20-200 μL, 200-1000 μL
- 3. 37℃恒温箱，双蒸水或去离子水
- 4. 吸水纸
操作步骤
|
|
1.对应板孔中加入100μL标准品工作液或样本，37℃孵育90分钟 |
| 2.弃掉板内液体后，立即加入100μL生物素化抗体工作液，37℃孵育60分钟 | |
| 3.弃掉板内液体，洗板3次 | |
| 4.每孔加入100μL HRP酶结合物工作液，37℃孵育30分钟，弃掉板内液体，洗板5次 | |
| 5.每孔加入90μL底物溶液，37℃孵育15分钟 | |
| 6.每孔加入50μL终止液 | |
| 7.立即在450nm波长下读数，处理数据 |
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样品类型: Dendritic cells (DCs) - 文献: Selenium-enriched oolong tea (Camellia sinensis) extract exerts anti-inflammatory potential via targeting NF-κB and MAPK pathways in macrophages
样品类型: RAW264.7 cell - 文献: Fargesin ameliorates osteoarthritis via macrophage reprogramming by downregulating MAPK and NF-κB pathways
样品类型: Serum,Cell culture supernatant - 文献: A novel polysaccharide from Acorus tatarinowii protects against LPS-induced neuroinflammation and neurotoxicity by inhibiting TLR4-mediated MyD88/NF-κB and PI3K/Akt signaling pathways
样品类型: Cell culture supernatant - 文献: Size, surface charge and flexibility of vinegar-baked Radix Bupleuri polysaccharide affecting the immune response
样品类型: RAW264.7 cell - 文献: Regulatory role of NKG2D+ NK cells in intestinal lamina propria by secreting double-edged Th1 cytokines in ulcerative colitis
样品类型: Tissue homogenate - 文献: Glioblastoma progression is assisted by induction of immunosuppressive function of pericytes through interaction with tumor cells
样品类型: Cell culture supernatant - 文献: Emodin inhibits lipid accumulation and inflammation in adipose tissue of high-fat diet-fed mice by inducing M2 polarization of adipose tissue macrophages
样品类型: serum,macrophage cells - 文献: The dichloromethane extract of Callicarpa longissima rich in diterpenoid phenols exerts anti-inflammatory effect via inhibiting the TLR4/NF-κB signaling pathway
样品类型: RAW264.7 cells - 文献: Orally administered MOTS-c analogue ameliorates dextran sulfate sodium-induced colitis by inhibiting inflammation and apoptosis
样品类型: plasma - 文献: Lian-Qu formula treats metabolic syndrome via reducing fat synthesis, insulin resistance and inflammation
样品类型: serum - 文献: High fiber multigrain supplementation improved disease activity score, circulating inflammatory and oxidative stress biomarkers in rheumatoid arthritis (RA) patients: A randomized human clinical trial
样品类型: blood - 文献: DNMT3b-mediated methylation of ZSWIM3 enhances inflammation in alcohol-induced liver injury via regulating TRAF2-mediated NF-κB pathway
样品类型: RAW264.7 cell - 文献: Inhibition of phosphodiesterase-4 in the spinal dorsal horn ameliorates neuropathic pain via cAMP-cytokine-Cx43 signaling in mice
样品类型: spinal cord - 文献: PEA-OXA ameliorates allodynia, neuropsychiatric and adipose tissue remodeling induced by social isolation
样品类型: Mesenchymal stromal cells (MSCs) - 文献: Twelve novel sesquiterpenes with anti-inflammatory and cholesterol-lowering activities from burdock leaves
样品类型: RAW264.7 cell - 文献: Probiotic Bacillus cereus Alleviates Dextran Sulfate Sodium-Induced Colitis in Mice through Improvement of the Intestinal Barrier Function, Anti-Inflammation, and Gut Microbiota Modulation
样品类型: colon tissue - 文献: Laminaria japonica Polysaccharide Suppresses Atherosclerosis via Regulating Autophagy-Mediated Macrophage Polarization
样品类型: aortic,Raw264.7 cell - 文献: Industrially Produced Rice Protein Ameliorates Dextran Sulfate Sodium-Induced Colitis via Protecting the Intestinal Barrier, Mitigating Oxidative Stress, and Regulating Gut Microbiota
样品类型: Colon tissue - 文献: Algal Oil Rich in Docosahexaenoic Acid Alleviates Intestinal Inflammation Induced by Antibiotics Associated with the Modulation of the Gut Microbiome and Metabolome
样品类型: Tissue homogenate(colon) - 文献: Fecal Microbiota Transplantation Protects the Intestinal Mucosal Barrier by Reconstructing the Gut Microbiota in a Murine Model of Sepsis
样品类型: serum - 文献: Up-regulation of the human-specific CHRFAM7A gene protects against renal fibrosis in mice with obstructive nephropathy
样品类型: serum - 文献: Osteocytic cells exposed to titanium particles increase sclerostin expression and inhibit osteoblastic cell differentiation mostly via direct cell-to-cell contact
样品类型: MLO-Y4 cell,MC3T3-E1cell - 文献: Synthesis of mitochondria-targeted ferulic acid amide derivatives with antioxidant, anti-inflammatory activities and inducing mitophagy
样品类型: RAW264.7 cell - 文献: Verapamil inhibits early acute liver failure through suppressing the NLRP3 inflammasome pathway
样品类型: Tissue homogenate - 文献: Pseudolaric acid B ameliorates synovial inflammation and vessel formation by stabilizing PPARγ to inhibit NF-κB signalling pathway
样品类型: Raw 264.7 cells - 文献: Oxidized high-density lipoprotein enhances endocrine disorders and ovarian damage in rats
样品类型: granulosa cells (GCs) - 文献: A comparative study of fermented buffalo and camel milk with anti-inflammatory, ACE-inhibitory and anti-diabetic properties and release of bio active peptides with molecular interactions: In vitro, in silico and molecular study
样品类型: RAW 264.7 cell - 文献: Bioactive constituents of Mosla chinensis-cv. Jiangxiangru ameliorate inflammation through MAPK signaling pathways and modify intestinal microbiota in DSS-induced colitis mice
样品类型: colon tissue - 文献: Combined royal jelly 10-hydroxydecanoic acid and aspirin has a synergistic effect against memory deficit and neuroinflammation
样品类型: BV-2 cell - 文献: Bioactivity-guided isolation of the major anthocyanin from Lycium ruthenicum Murr. fruit and its antioxidant activity and neuroprotective effects in vitro and in vivo
样品类型: hippocampus - 文献: Bioactives and their metabolites from Tetrastigma hemsleyanum leaves ameliorate DSS-induced colitis via protecting intestinal barrier, mitigating oxidative stress and regulating gut microbiota
样品类型: colon tissue - 文献: Astilbin from Smilax glabra Roxb. alleviates high-fat diet-induced metabolic dysfunction
样品类型: serum - 文献: Anti-inflammatory effects of anemonin on acute ulcerative colitis via targeted regulation of protein kinase C-θ
样品类型: colon tissues - 文献: Inhibitory activity of gintonin on inflammation in human IL-1β-stimulated fibroblast-like synoviocytes and collagen-induced arthritis in mice
样品类型: serum - 文献: The Effects of Angelica Sinensis Polysaccharide on Tumor Growth and Iron Metabolism by Regulating Hepcidin in Tumor-Bearing Mice
样品类型: Serum - 文献: Encapsulation of Functional Plant Oil by Spray Drying: Physicochemical Characterization and Enhanced Anti-Colitis Activity
样品类型: serum - 文献: Maternal exposure to a glyphosate-based herbicide impairs placental development through endoplasmic reticulum stress in mice
样品类型: Placental tissue - 文献: Melatonin Derivatives Combat with Inflammation-related Cancer by Targeting the Main Culprit STAT3
样品类型: Cell culture supernatant - 文献: Selective GSK3β Inhibition Mediates an Nrf2-Independent Anti-inflammatory Microglial Response
样品类型: SIM-A9 cell - 文献: Broccoli microgreens juice reduces body weight by enhancing insulin sensitivity and modulating gut microbiota in high-fat diet-induced C57BL/6J obese mice
样品类型: Serum - 文献: Corilagin Interferes With Toll-Like Receptor 3-Mediated Immune Response in Herpes Simplex Encephalitis
样品类型: brain tissues,BV-2 cells - 文献: Oral administration of 3,3′-diselenodipropionic acid prevents thoracic radiation induced pneumonitis in mice by suppressing NF-kB/IL-17/G-CSF/neutrophil axis
样品类型: Bronchoalveolar Lavage Fluid,Tissue homogenate - 文献: Investigating the mechanisms of Modified Xiaoyaosan (tiaogan-liqi prescription) in suppressing the progression of atherosclerosis, by means of integrative pharmacology and experimental validation
样品类型: Plasma - 文献: CHIP ameliorates cerebral ischemia-reperfusion injury by attenuating necroptosis and inflammation
样品类型: brain - 文献: Activation of Angiotensin-converting Enzyme 2 Protects Against Lipopolysaccharide-induced Glial Activation by Modulating Angiotensin-converting Enzyme 2/Angiotensin (1–7)/Mas Receptor Axis
样品类型: BV2 cell - 文献: Baicalin ameliorates neuroinflammation-induced depressive-like behavior through inhibition of toll-like receptor 4 expression via the PI3K/AKT/FoxO1 pathway
样品类型: hippocampus tissue,BV2 cells,primary microglia cells - 文献: C1q/tumor necrosis factor-related protein-6 exerts protective effects on myocardial ischemia–reperfusion injury through the modulation of the Akt-GSK-3β-Nrf2 signaling cascade
样品类型: cardiac muscle tissues,cardiomyocytes - 文献: Friedelin Alleviates the Pathogenesis of Collagenase-Induced Tendinopathy in Mice by Promoting the Selective Autophagic Degradation of p65
样品类型: serum,tenocytes - 文献: Systemic exosomal miR-193b-3p delivery attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage in mice
样品类型: brain - 文献: Wu-Mei-Wan Ameliorates Murine Ulcerative Colitis by Regulating Macrophage Polarization
样品类型: Serum - 文献: The Effect of Shionone on Sepsis-Induced Acute Lung Injury by the ECM1/STAT5/NF-κB Pathway
样品类型: serum,RAW264.7 cell - 文献: Naringin Interferes Doxorubicin-Induced Myocardial Injury by Promoting the Expression of ECHS1
样品类型: heart tissue - 文献: Excessive Intake of Longan Arillus Alters gut Homeostasis and Aggravates Colitis in Mice
样品类型: Serum - 文献: Ethyl 2-Succinate-Anthraquinone Attenuates Inflammatory Response and Oxidative Stress via Regulating NLRP3 Signaling Pathway.
样品类型: blood - 文献: Emodin Attenuates Lipopolysaccharide-Induced Acute Liver Injury via Inhibiting the TLR4 Signaling Pathway in vitro and in vivo
样品类型: Cell culture supernatant - 文献: Activation of G protein‐coupled receptor 30 protects neurons by regulating autophagy in astrocytes
样品类型: astrocytes - 文献: Tuftsin ameliorates splenic inflammatory injury by promoting neuropilin-1 in severe acute pancreatitis
样品类型: serum - 文献: Inflammation-targeted sialic acid-dexamethasone conjugates for reducing the side effects of glucocorticoids
样品类型: kidney - 文献: Nimbolide attenuates gut dysbiosis and prevents bacterial translocation by improving intestinal barrier integrity and ameliorating inflammation in hepatocellular carcinoma
样品类型: plasma - 文献: Rice Protein Peptides Alleviate Dextran Sulfate Sodium-Induced Colitis via the Keap1–Nrf2 Signaling Pathway and Regulating Gut Microbiota
样品类型: colon tissue - 文献: Farnesol-Loaded Liposomes Protect the Epidermis and Dermis from PM2.5-Induced Cutaneous Injury
样品类型: L929 fibroblasts cells - 文献: N-Acetyl cysteine effectively alleviates Coxsackievirus B-Induced myocarditis through suppressing viral replication and inflammatory response
样品类型: heart - 文献: MiR-146b-5p/TRAF6 axis is essential for Ginkgo biloba L. extract GBE to attenuate LPS-induced neuroinflammation
样品类型: BV-2 cell - 文献: Midazolam Ameliorates Acute Liver Injury Induced by Carbon Tetrachloride via Enhancing Nrf2 Signaling Pathway
样品类型: liver - 文献: Metformin Improves the Senescence of Renal Tubular Epithelial Cells in a High-Glucose State Through E2F1
样品类型: renal cortical - 文献: PGC-1 silencing compounds the perturbation of mitochondrial function caused by mutant SOD1 in skeletal muscle of ALS mouse model
样品类型: Serum - 文献: The Influence of Acanthamoeba–Legionella Interaction in the Virulence of Two Different Legionella Species
样品类型: Cell culture supernatant - 文献: A Natural Plant Ingredient, Menthone, Regulates T Cell Subtypes and Lowers Pro-inflammatory Cytokines of Rheumatoid Arthritis
样品类型: blood - 文献: Xiaoyaosan prevents atherosclerotic vulnerable plaque formation through heat shock protein/glucocorticoid receptor axis-mediated mechanism
样品类型: serum - 文献: Ameliorative effects of snake (Deinagkistrodon acutus) oil and its main fatty acids against UVB-induced skin photodamage in mice
样品类型: skin - 文献: Structural analysis and immunoregulation activity comparison of five polysaccharides from Angelica sinensis
样品类型: Cell culture supernatant - 文献: Sesamin suppresses advanced glycation end products induced microglial reactivity using BV2 microglial cell line as a model
样品类型: Cell culture medium - 文献: Geniposide protects depression through BTK/JAK2/STAT1 signaling pathway in lipopolysaccharide-induced depressive mice
样品类型: Serum,Cell culture supernatant,Tissue homogenate - 文献: Ex vivo tolerization and M2 polarization of macrophages dampens both pro- and anti-inflammatory cytokine production in response to diabetic wound fluid stimulation
样品类型: wound fluid,J774A.1 monocytic cell - 文献: Selenium Supplementation Protects Against Arsenic-Trioxide-Induced Cardiotoxicity Via Reducing Oxidative Stress and Inflammation Through Increasing NAD+ Pool
样品类型: heart tissue - 文献: The effect of geniposide on chronic unpredictable mild stress‐induced depressive mice through BTK/TLR4/NF‐κB and BDNF/TrkB signaling pathways
样品类型: Serum,Tissue homogenate,Cell culture supernatant - 文献: Protective Effect of Prunus mume Fermented with Mixed Lactic Acid Bacteria in Dextran Sodium Sulfate-Induced Colitis
样品类型: colon tissue,serum - 文献: Cannabinoid Analogue WIN 55212–2 Protects Paraquat-Induced Lung Injury and Enhances Macrophage M2 Polarization
样品类型: BALF - 文献: Benzoylaconine Modulates LPS-Induced Responses Through Inhibition of Toll-Like Receptor-Mediated NF-κB and MAPK Signaling in RAW264.7 Cells
样品类型: RAW264.7 cells - 文献: FXII regulates the formation of deep vein thrombosis via the PI3K/AKT signaling pathway in mice
样品类型: femoral vein tissue,plasma - 文献: Upregulation of FAM129B protects cardiomyocytes from hypoxia/reoxygenation-induced injury by inhibiting apoptosis, oxidative stress, and inflammatory response via enhancing Nrf2/ARE activation
样品类型: cardiomyocytes - 文献: Inhibition of USP15 ameliorates high-glucose-induced oxidative stress and inflammatory injury in podocytes through regulation of the Keap1/Nrf2 signaling
样品类型: MPC5 cell - 文献: Effects of 2,4-dichlorophenoxyacetic acid on the expression of NLRP3 inflammasome and autophagy-related proteins as well as the protective effect of Lycium barbarum polysaccharide in neonatal rats
样品类型: BV2 cell - 文献: C1q/tumor necrosis factor-related protein 9 protects cultured chondrocytes from IL-1β-induced inflammatory injury by inhibiting NLRP3 inflammasome activation via the AdipoR1/AMPK axis
样品类型: chondrocytes - 文献: 2,4-dichlorophenoxyacetic acid induces ROS activation in NLRP3 inflammatory body-induced autophagy disorder in microglia and the protective effect of Lycium barbarum polysaccharide
样品类型: BV2 cell - 文献: Preventive effect of tilapia skin collagen hydrolysates on ulcerative colitis mice based on metabonomic and 16S rRNA gene sequencing
样品类型: serum - 文献: Didymin Ameliorates Liver Fibrosis by Alleviating Endoplasmic Reticulum Stress and Glycerophospholipid Metabolism: Based on Transcriptomics and Metabolomics
样品类型: liver - 文献: The Preventive and Curative Effects of Lactobacillus reuteri NK33 and Bifidobacterium adolescentis NK98 on Immobilization Stress-Induced Anxiety/Depression and Colitis in Mice
样品类型: blood,BV-2 cells - 文献: Polyphenol rich extracts of finger millet and kodo millet ameliorate high fat diet-induced metabolic alterations
样品类型: Cell culture supernatant - 文献: Flaxseed oligosaccharides alleviate DSS-induced colitis through modulation of gut microbiota and repair of the intestinal barrier in mice
样品类型: Serum,Tissue homogenate - 文献: Akebia trifoliata pericarp extract ameliorates inflammation through NF-κB/MAPK signaling pathways and modifies gut microbiota
样品类型: colon tissue - 文献: Salidroside Ameliorates Renal Interstitial Fibrosis by Inhibiting the TLR4/NF-κB and MAPK Signaling Pathways
样品类型: Serum - 文献: Resveratrol Plays a Protective Role against Premature Ovarian Failure and Prompts Female Germline Stem Cell Survival
样品类型: Serum,Cell culture supernatant - 文献: A probiotic treatment increases the immune response induced by the nasal delivery of spore-adsorbed TTFC
样品类型: Cell culture supernatant - 文献: H5N1 avian influenza virus without 80–84 amino acid deletion at the NS1 protein hijacks the innate immune system of dendritic cells for an enhanced mammalian pathogenicity
样品类型: Cell culture supernatant - 文献: Novel Biomedical Functions of Surfactin A from Bacillus subtilis in Wound Healing Promotion and Scar Inhibition
样品类型: Cell culture supernatant - 文献: Modulation of Gut Microbiota by Fucoxanthin During Alleviation of Obesity in High-Fat Diet-Fed Mice
样品类型: Serum,Tissue homogenate - 文献: O-alkyl and o-benzyl hesperetin derivative-1L attenuates inflammation and protects against alcoholic liver injury via inhibition of BRD2-NF-κB signaling pathway
样品类型: serum,RAW264.7 cell - 文献: TSG-6 Inhibits Oxidative Stress and Induces M2 Polarization of Hepatic Macrophages in Mice With Alcoholic Hepatitis via Suppression of STAT3 Activation
样品类型: serum - 文献: Hyperoside Attenuates Bleomycin-Induced Pulmonary Fibrosis Development in Mice.
样品类型: Tissue Slice - 文献: Pulsed Electromagnetic Fields Protect Against Brain Ischemia by Modulating the Astrocytic Cholinergic Anti-inflammatory Pathway
样品类型: brain tissue,primary astrocytes - 文献: Algal Oil Rich in n-3 PUFA Alleviates DSS-Induced Colitis via Regulation of Gut Microbiota and Restoration of Intestinal Barrier
样品类型: serum - 文献: Exploring the potential of Lactobacillus and Saccharomyces for biofunctionalities and the release of bioactive peptides from whey protein fermentate
样品类型: RAW264.7 cell - 文献: Exploring potentials of antioxidative, anti-inflammatory activities and production of bioactive peptides in lactic fermented camel milk
样品类型: RAW 264.7 cell - 文献: Antioxidative, antimicrobial and anti-inflammatory activities and release of ultra-filtered antioxidative and antimicrobial peptides during fermentation of sheep milk: In-vitro, in-silico and molecular interaction studies
样品类型: RAW 264.7 murine macrophage cell - 文献: Glycyrrhiza uralensis water extract enhances dendritic cell maturation and antitumor efficacy of HPV dendritic cell-based vaccine
样品类型: Cell culture supernatant - 文献: Identification and molecular mechanisms of novel antioxidative peptides from fermented camel milk (Kachchi breed, India) with anti-inflammatory activity in raw macrophages cell lines
样品类型: RAW 264.7 cells - 文献: Antidiabetic, angiotensin-converting enzyme inhibitory and anti-inflammatory activities of fermented camel milk and characterisation of novel bioactive peptides from lactic-fermented camel milk with molecular interaction study
样品类型: RAW 264.7 cell - 文献: Effects of silver nanoparticles in combination with antibiotics on the resistant bacteria Acinetobacter baumannii
样品类型: Plasma - 文献: Green Pea (Pisum sativum L.) Hull Polyphenol Extracts Ameliorate DSS-Induced Colitis through Keap1/Nrf2 Pathway and Gut Microbiota Modulation
样品类型: colon - 文献: Tanshinol alleviates ulcerative colitis by promoting the expression of VLDLR
样品类型: colon - 文献: In vitro and in vivo relaxation and anti-inflammation of natural flavonoids from Elaeagnus pungens leaf via L-type calcium channel and targeting MAPK signal pathway
样品类型: Cell culture supernatant - 文献: Danggui Buxue Decoction enhances the anticancer activity of gemcitabine and alleviates gemcitabine-induced myelosuppression
样品类型: Serum,Tissue(spleen) - 文献: Modulation of LPA1 receptor-mediated neuronal apoptosis by Saikosaponin-d: A target involved in depression
样品类型: hippocampus tissue - 文献: Adenosine receptor A2B mediates alcoholic hepatitis by regulating cAMP levels and the NF-KB pathway
样品类型: serum,RAW264.7 cell - 文献: The protective effect of the PDE-4 inhibitor rolipram on intracerebral haemorrhage is associated with the cAMP/AMPK/SIRT1 pathway
样品类型: Brain tissue - 文献: Studies on the mitochondrial, immunological and inflammatory effects of solvent fractions of Diospyros mespiliformis Hochst in Plasmodium berghei-infected mice
样品类型: Serum - 文献: Mebendazole, an anti-helminth drug, suppresses inflammation, oxidative stress and injury in a mouse model of ulcerative colitis
样品类型: colon tissue - 文献: Hepatoprotective effect of Thymus vulgaris extract on sodium nitrite-induced changes in oxidative stress, antioxidant and inflammatory marker expression
样品类型: Serum - 文献: Virus-like hollow mesoporous silica nanoparticles for cancer combination therapy
样品类型: Serum - 文献: Attenuation of virulence in multiple serotypes (M1, M3, and M28) of Group A Streptococcus after the loss of secreted esterase
样品类型: skin lesion - 文献: The therapeutic potential of chondroitin sulfate in Aspergillus fumigatus keratitis
样品类型: corneas,RAW 264.7 cell - 文献: Activation of TLR4 induces severe acute pancreatitis-associated spleen injury via ROS-disrupted mitophagy pathway
样品类型: serum,spleen tissue - 文献: The Expression and Bioinformatics Analysis of Circular RNAs in Endometritis Mouse Uterus Tissues
样品类型: uterine tissue - 文献: Study of the Osteoimmunomodulatory Properties of Curcumin-Modified Copper-Bearing Titanium
样品类型: RAW 264.7 cell - 文献: Rosmanol and Carnosol Synergistically Alleviate Rheumatoid Arthritis through Inhibiting TLR4/NF-κB/MAPK Pathway
样品类型: serum - 文献: The protective effect of Palmatine on depressive like behavior by modulating microglia polarization in LPS-induced mice
样品类型: hippocampus,BV2 cell - 文献: Peripheral Administration of a Cell-Penetrating MOTS-c Analogue Enhances Memory and Attenuates Aβ1–42- or LPS-Induced Memory Impairment through Inhibiting Neuroinflammation
样品类型: Tissue homogenate(hippocampus) - 文献: Seizure-induced neuroinflammation contributes to ectopic neurogenesis and aggressive behavior in pilocarpine-induced status epilepticus mice
样品类型: Cell lysate - 文献: Research on the effect and underlying molecular mechanism of Cangzhu in the treatment of gouty arthritis
样品类型: RAW264.7-cell - 文献: Isovitexin protects against acute liver injury by targeting PTEN, PI3K and BiP via modification of m6A
样品类型: serum - 文献: Structural characterization and immunomodulatory activity of a glucan from Radix Codonopsis
样品类型: Cell culture supernatant - 文献: N-acetyl-chitooligosaccharide attenuates inflammatory responses by suppression of NF-κB signaling, MAPK and NLRP3 inflammasome in macrophages
样品类型: Cell culture medium - 文献: Effect of κ-carrageenan on glucolipid metabolism and gut microbiota in high-fat diet-fed mice
样品类型: serum - 文献: Antioxidative mechanisms and anticolitic potential of Desmodium styracifolium (Osb.) Merr. in DSS-induced colitic mice
样品类型: colonic tissue - 文献: CIP2A-promoted astrogliosis induces AD-like synaptic degeneration and cognitive deficits
样品类型: Tissue homogenate,Cell culture medium - 文献: Dihydrokaempferol attenuates CCl4-induced hepatic fibrosis by inhibiting PARP-1 to affect multiple downstream pathways and cytokines
样品类型: serum - 文献: Terpene-rich fractions of Ficus mucoso (Welw) modulate lipopolysaccharide-induced inflammatory mediators and aberrant permeability of the inner mitochondrial membrane in murine animal model
样品类型: serum - 文献: The stiffness‐controlled release of interleukin‐6 by cardiac fibroblasts is dependent on integrin α2β1
样品类型: Serum - 文献: Polysaccharides from Dicliptera chinensis ameliorate liver disturbance by regulating TLR‐4/NF‐κB and AMPK/Nrf2 signalling pathways
样品类型: Serum,Tissue homogenate - 文献: Defibrotide inhibits donor leucocyte‐endothelial interactions and protects against acute graft‐versus‐host disease
样品类型: Plasma - 文献: Inflammatory kidney injury in trichloroethylene hypersensitivity syndrome mice: Possible role of C3a receptor in the accumulation of Th17 phenotype
样品类型: Serum - 文献: Integrative Analysis of Transcriptome and Metabolome to Illuminate the Protective Effects of Didymin against Acute Hepatic Injury
样品类型: Serum - 文献: Study on the protective effect and mechanism of Dicliptera chinensis (L.) Juss (Acanthaceae) polysaccharide on immune liver injury induced by LPS
样品类型: Tissue homogenate - 文献: MG-132 attenuates cardiac deterioration of viral myocarditis via AMPK pathway
样品类型: Plasma - 文献: Marein ameliorates diabetic nephropathy by inhibiting renal sodium glucose transporter 2 and activating the AMPK signaling pathway in db/db mice and high glucose–treated HK-2 cells
样品类型: serum - 文献: Dihydrotanshinone attenuates chemotherapy-induced intestinal mucositis and alters fecal microbiota in mice
样品类型: serum - 文献: Fermented Morinda citrifolia (Noni) Alleviates DNCB-Induced Atopic Dermatitis in NC/Nga Mice through Modulating Immune Balance and Skin Barrier Function
样品类型: Serum,Cell culture supernatant - 文献: Chinese Propolis Prevents Obesity and Metabolism Syndromes Induced by a High Fat Diet and Accompanied by an Altered Gut Microbiota Structure in Mice
样品类型: Serum - 文献: Bifidobacteria-Fermented Red Ginseng and Its Constituents Ginsenoside Rd and Protopanaxatriol Alleviate Anxiety/Depression in Mice by the Amelioration of Gut Dysbiosis
样品类型: Tissue homogenate - 文献: Osthole Blocks HMGB1 Release From the Nucleus and Confers Protective Effects Against Renal Ischemia-Reperfusion Injury.
样品类型: renal tissue - 文献: The Protective Effect of Anthocyanins Extracted from Aronia Melanocarpa Berry in Renal Ischemia-Reperfusion Injury in Mice
样品类型: Serum - 文献: Curcumin Targeting NF-κB/Ubiquitin-Proteasome-System Axis Ameliorates Muscle Atrophy in Triple-Negative Breast Cancer Cachexia Mice
样品类型: gastrocnemius tissue,4T1 cell-Xenograft - 文献: Intranasal MMI-0100 Attenuates Aβ1−42- and LPS-Induced Neuroinflammation and Memory Impairments via the MK2 Signaling Pathway
样品类型: Tissue homogenate - 文献: Lipopolysaccharide exacerbates chronic restraint stress-induced neurobehavioral deficits: Mechanisms by redox imbalance, ASK1-related apoptosis, autophagic dysregulation
样品类型: serum,brain - 文献: Inula japonica ameliorated the inflammation and oxidative stress in LPS-induced acute lung injury through the MAPK/NF-κB and Keap1/Nrf2 signalling pathways
样品类型: lung - 文献: Targeting IL-17A Improves the Dysmotility of the Small Intestine and Alleviates the Injury of the Interstitial Cells of Cajal during Sepsis
样品类型: Tissue homogenate - 文献: Reactive Oxygen Species Are Involved in the Development of Gastric Cancer and Gastric Cancer-Related Depression through ABL1-Mediated Inflammation Signaling Pathway
样品类型: blood - 文献: Maggot Extracts Alleviate Inflammation and Oxidative Stress in Acute Experimental Colitis via the Activation of Nrf2
样品类型: Serum - 文献: The Role of Indoleamine 2,3-Dioxygenase in Renal Tubular Epithelial Cells Senescence under Anoxia or Reoxygenation
样品类型: RPTEC - 文献: Two Pairs of 7,7′-Cyclolignan Enantiomers with Anti-Inflammatory Activities from Perilla frutescens
样品类型: Raw 264.7 cell - 文献: Neuroprotective Effects of Savinin on LPS-Induced Neuroinflammation In Vivo via Regulating MAPK/NF-κB Pathway and NLRP3 Inflammasome Activation
样品类型: Serum - 文献: Monkfish (Lophius litulon) Peptides Ameliorate High-Fat-Diet-Induced Nephrotoxicity by Reducing Oxidative Stress and Inflammation via Regulation of Intestinal Flora
样品类型: renal tissue - 文献: Senescence marker protein 30 (SMP30) protects against high glucose-induced apoptosis, oxidative stress and inflammatory response in retinal ganglion cells by enhancing Nrf2 activation via regulation of Akt/GSK-3β pathway
样品类型: RGCs - 文献: Protective effect of combination of anakinra and MCC950 against acute lung injury is achieved through suppression of the NF-κB-mediated-MAPK and NLRP3-caspase pathways
样品类型: Tissue homogenate(lung),Bronchoalveolar Lavage Fluid - 文献: Oxymatrine inhibits neuroinflammation by Regulating M1/M2 polarization in N9 microglia through the TLR4/NF-κB pathway
样品类型: N9 microglial cell - 文献: Inhibition of P2Y6 receptor expression in Kupffer cells alleviates alcoholic steatohepatitis in mice
样品类型: serum,RAW264.7 cell - 文献: Hydrogen gas alleviates sepsis-induced neuroinflammation and cognitive impairment through regulation of DNMT1 and DNMT3a-mediated BDNF promoter IV methylation in mice
样品类型: Tissue homogenate(hippocampal tissues) - 文献: High-density lipoprotein reduces microglia activation and protects against experimental autoimmune encephalomyelitis in mice
样品类型: plasma,BV2 microglial cell - 文献: Empagliflozin, a sodium glucose cotransporter-2 inhibitor, ameliorates peritoneal fibrosis via suppressing TGF-β/Smad signaling
样品类型: peritoneal dialysis solution,Cell culture supernatant - 文献: COX-2-PGE2 signaling pathway contributes to hippocampal neuronal injury and cognitive impairment in PTZ-kindled epilepsy mice
样品类型: Tissue homogenate - 文献: Bixin protects mice against bronchial asthma though modulating PI3K/Akt pathway
样品类型: BALF - 文献: Atractyloside-A ameliorates spleen deficiency diarrhea by interfering with TLR4/MyD88/NF-κB signaling activation and regulating intestinal flora homeostasis
样品类型: colon tissue - 文献: Artesunate attenuates atherosclerosis by inhibiting macrophage M1-like polarization and improving metabolism
样品类型: plasma - 文献: Arsenic trioxide improves Treg and Th17 balance by modulating STAT3 in treatment-naïve rheumatoid arthritis patients
样品类型: serum - 文献: Arsenic Trioxide in Synergy with Vitamin D Rescues the Defective VDR-PPAR- Functional Module of Autophagy in Rheumatoid Arthritis
样品类型: serum - 文献: CaMK4‐dependent phosphorylation of Akt/mTOR underlies Th17 excessive activation in experimental autoimmune prostatitis
样品类型: Cell culture supernatant,Tissue homogenate,serum - 文献: Conditioned medium of mesenchymal stem cells pretreated with H2O2 promotes intestinal mucosal repair in acute experimental colitis
样品类型: colon tissue - 文献: lncRNA SNHG12 Inhibition Based on Microsystem Cell Imaging Technology Protects the Endothelium from LPS-Induced Inflammation by Inhibiting the Expression of miR-140-3p Target Gene fndc5
样品类型: BALF,PMVEC - 文献: L-Carnitine Alleviates the Myocardial Infarction and Left Ventricular Remodeling through Bax/Bcl-2 Signal Pathway
样品类型: plasma - 文献: MiR-181-5p protects mice from sepsis via repressing HMGB1 in an experimental model
样品类型: Serum - 文献: Bexarotene Improve Depression-Like Behaviour in Mice by Protecting Against Neuro-inflammation and Synaptic Damage
样品类型: Tissue homogenate - 文献: MMI-0100 Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice through Targeting MK2 Pathway
样品类型: colon - 文献: Design, Synthesis and Investigation of the Potential Anti-Inflammatory Activity of 7-O-Amide Hesperetin Derivatives
样品类型: Cell culture supernatant - 文献: Diosgenin glucoside protects against myocardial injury in diabetic mice by inhibiting RIP140 signaling
样品类型: serum,cardiac tissue - 文献: Nuciferine Inhibits Proinflammatory Cytokines via the PPARs in LPS-Induced RAW264.7 Cells
样品类型: Cell culture supernatant - 文献: B-cell-specific mammalian target of rapamycin complex 1 activation results in severe osteoarthritis in mice
样品类型: serum - 文献: Anti-Nociceptive and Anti-Inflammatory Activities of the Ethyl Acetate Extract of Belamcanda chinensis (L.) Redouté in Raw 264.7 Cells in vitro and Mouse Model in vivo
样品类型: RAW264.7 cell - 文献: Pancreastatin inhibitor PSTi8 attenuates hyperinsulinemia induced obesity and inflammation mediated insulin resistance via MAPK/NOX3-JNK pathway
样品类型: Plasma - 文献: Circular RNA expression profile of liver tissues in an EtOH-induced mouse model of alcoholic hepatitis
样品类型: Serum,Tissue homogenate - 文献: Anti-fatigue activity of purified anthocyanins prepared from purple passion fruit (P. edulis Sim) epicarp in mice
样品类型: Tissue homogenate - 文献: miR-128-3p Inhibits NRP1 Expression and Promotes Inflammatory Response to Acute Kidney Injury in Sepsis
样品类型: TCMK-1 cell - 文献: Casticin Attenuates Osteoarthritis-Related Cartilage Degeneration by Inhibiting the ROS-Mediated NF-κB Signaling Pathway in vitro and in vivo
样品类型: serum,ADTC5 cell - 文献: Osthole prevents acetaminophen-induced liver injury in mice
样品类型: Tissue homogenate - 文献: Diet-Derived Advanced Glycation End Products (dAGEs) Induce Proinflammatory Cytokine Expression in Cardiac and Renal Tissues of Experimental Mice: Protective Effect of Curcumin
样品类型: serum - 文献: Propacin, a coumarinolignoid isolated from durian, inhibits the lipopolysaccharide-induced inflammatory response in macrophages through the MAPK and NF-κB pathways
样品类型: Cell culture supernatant - 文献: Blockade of high mobility group box 1 involved in the protective of curcumin on myocardial injury in diabetes in vivo and in vitro
样品类型: Serum - 文献: Glucagon-like peptide-1 cleavage product GLP-1(9–36) reduces neuroinflammation from stroke via the activation of insulin-like growth factor 1 receptor in astrocytes
样品类型: Cell culture supernatant - 文献: Anti-Inflammatory Effect of Simonsinol on Lipopolysaccharide Stimulated RAW264.7 Cells through Inactivation of NF-κB Signaling Pathway
样品类型: Cell culture supernatant - 文献: A Herbal Mixture from Propolis, Pomegranate, and Grape Pomace Endowed with Anti-Inflammatory Activity in an In Vivo Rheumatoid Arthritis Model
样品类型: serum - 文献: Synergetic protective effect of berberine and ginsenoside Rb1 against tumor necrosis factor alpha−induced inflammation in adipocytes
样品类型: 3T3-L1 preadipocyte - 文献: Shikonin combined with methotrexate regulate macrophage polarization to treat psoriasis
样品类型: RAW264.7 cell - 文献: Guizhi Fuling pill attenuates liver fibrosis in vitro and in vivo via inhibiting TGF-β1/Smad2/3 and activating IFN-γ/Smad7 signaling pathways
样品类型: liver tissue - 文献: Cabergoline possesses a beneficial effect on blood-brain barrier (BBB) integrity against lipopolysaccharide (LPS)
样品类型: brain tissue - 文献: Blocking the CD38/cADPR pathway plays a double-edged role in LPS stimulated microglia
样品类型: Cell culture supernatant - 文献: Anti-inflammatory effect of a novel synthetic compound 1-((4-fluorophenyl)thio)isoquinoline in RAW264.7 macrophages and a zebrafish model
样品类型: Cell culture supernatant - 文献: MicroRNA-27a alleviates LPS-induced acute lung injury in mice via inhibiting inflammation and apoptosis through modulating TLR4/MyD88/NF-κB pathway
样品类型: bronchoalveolar lavage fluid (BALF),RAW 264.7 cells - 文献: 2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione isolated from Averrhoa carambola L. root ameliorates diabetic nephropathy by inhibiting the TLR4/MyD88/NF-κB pathway
样品类型: kidney - 文献: Regulation of CD39 expression in ATP-P2Y2R-mediated alcoholic liver steatosis and inflammation
样品类型: Serum,Cell culture supernatant - 文献: Tetrahydroxy stilbene glucoside alleviates palmitic acid-induced inflammation and apoptosis in cardiomyocytes by regulating miR-129-3p/Smad3 signaling
样品类型: Cell culture supernatant - 文献: Honokiol alleviates sepsis-induced acute kidney injury in mice by targeting the miR-218-5p/heme oxygenase-1 signaling pathway
样品类型: Serum - 文献: Overexpression of lncRNA Gm43050 alleviates apoptosis and inflammation response induced by sevoflurane treatment by regulating miR-640/ZFP91
样品类型: primary hippocampal neurons - 文献: Development, optimisation and evaluation of chitosan nanoparticles of alendronate against Alzheimer’s disease in intracerebroventricular streptozotocin model for brain delivery
样品类型: Tissue homogenate - 文献: Portulaca Extract Attenuates Development of Dextran Sulfate Sodium Induced Colitis in Mice through Activation of PPARγ
样品类型: serum - 文献: Suppressive Effects of Gelsemine on Anxiety-like Behaviors Induced by Chronic Unpredictable Mild Stress in Mice
样品类型: brain tissue - 文献: MiR-340-5p alleviates neuroinflammation and neuronal injury via suppressing STING in subarachnoid hemorrhage
样品类型: brain tissue,microglia - 文献: Pregnane X receptor activation by its natural ligand Ginkgolide-A improves tight junction proteins expression and attenuates bacterial translocation in cirrhosis
样品类型: Plasma,Tissue homogenate - 文献: VX765, a Specific Caspase-1 Inhibitor, Alleviates Lung Ischemia Reperfusion Injury by Suppressing Endothelial Pyroptosis and Barrier Dysfunction
样品类型: lung tissue,serum,PMVEC - 文献: Protective Effect of Luteolin on D-Galactosamine (D-Gal)/Lipopolysaccharide (LPS) Induced Hepatic Injury by in Mice
样品类型: serum,liver - 文献: The protective effect of Geniposide on diabetic cognitive impairment through BTK/TLR4/NF-κB pathway
样品类型: Serum - 文献: Attractylone attenuates sepsis‐associated encephalopathy and cognitive dysfunction by inhibiting microglial activation and neuroinflammation
样品类型: Cell culture supernatant,Tissue homogenate - 文献: The protective effect of formononetin on cognitive impairment in streptozotocin (STZ)-induced diabetic mice
样品类型: Serum,Tissue homogenate - 文献: Antineuroinflammatory Effects of 7,3’,4’-Trihydroxyisoflavone in Lipopolysaccharide-Stimulated BV2 Microglial Cells through MAPK and NF-κB Signaling Suppression
样品类型: Cell culture supernatant - 文献: Mesenchymal Stem Cells Promote Intestinal Mucosal Repair by Positively Regulating the Nrf2/Keap1/ARE Signaling Pathway in Acute Experimental Colitis
样品类型: colon tissue - 文献: Curcumin prevents osteocyte apoptosis by inhibiting M1‐type macrophage polarization in mice model of glucocorticoid‐associated osteonecrosis of the femoral head
样品类型: peripheral blood - 文献: (3α)-3-(tiglinoyloxy)-ent-kaur-16-en-19-oic acid, isolated from Wedelia trilobata L., exerts an anti-inflammatory effect via the modulation of NF-κB, MAPK and mTOR pathway and autophagy in LPS-stimulated macrophages
样品类型: Cell culture supernatant - 文献: Macrophage Distribution Affected by Virus-Encoded Granulocyte Macrophage Colony Stimulating Factor Combined with Lactate Oxidase
样品类型: RAW264.7 cell - 文献: Dendrobium Nobile Lindl Polysaccharides Attenuate UVB-Induced Photodamage by Regulating Oxidative Stress, Inflammation and Mmps Expression in Mice Model
样品类型: skin - 文献: The modulatory impacts of Glycyrrhiza glabra extract against methotrexate-induced testicular dysfunction and oxidative stress
样品类型: serum - 文献: 4-Methylcoumarin-[5,6–g]-hesperetin attenuates inflammatory responses in alcoholic hepatitis through PPAR-γ activation
样品类型: Serum,Cell culture supernatant - 文献: Curcumin restrains hepatic glucose production by blocking cAMP/PKA signaling and reducing acetyl CoA accumulation in high-fat diet (HFD)-fed mice
样品类型: liver - 文献: Upregulated galectin-3 is not a critical disease mediator of cardiomyopathy induced by β2-adrenoceptor overexpression
样品类型: left ventricle (LV) tissues - 文献: Methamphetamine induced neuroinflammation in mouse brain and microglial cell line BV2: Roles of the TLR4/TRIF/Peli1 signaling axis
样品类型: Cell culture supernatant,Tissue homogenate - 文献: Sulforaphane protects myocardium from ischemia-reperfusion injury by regulating CaMKIIN2 and CaMKIIδ
样品类型: H9c2 cell - 文献: Loss of serine/threonine protein kinase 25 in retinal ganglion cells ameliorates high glucose-elicited damage through regulation of the AKT-GSK-3β/Nrf2 pathway
样品类型: retina ganglion cell - 文献: Pharmacological Postconditioning by Protocatechuic Acid Attenuates Brain Injury in Ischemia–Reperfusion (I/R) Mice Model: Implications of Nuclear Factor Erythroid-2-Related Factor Pathway
样品类型: brain - 文献: Protective roles and mechanisms of rosmarinic acid in cyclophosphamide‐induced premature ovarian failure
样品类型: Serum - 文献: SIRT1 activation by butein attenuates sepsis-induced brain injury in mice subjected to cecal ligation and puncture via alleviating inflammatory and oxidative stress
样品类型: Serum,Tissue homogenate - 文献: The Protective Effects of Melatonin Against LPS-Induced Septic Myocardial Injury: A Potential Role of AMPK-Mediated Autophagy
样品类型: Serum - 文献: Pretreatment of exosomes derived from hUCMSCs with TNF-α ameliorates acute liver failure by inhibiting the activation of NLRP3 in macrophage
样品类型: Whole Blood,Tissue homogenate - 文献: Effects of taraxasterol against ethanol and high-fat diet-induced liver injury by regulating TLR4/MyD88/NF-κB and Nrf2/HO-1 signaling pathways
样品类型: Serum - 文献: Camellia cake extracts reduce burn injury through suppressing inflammatory responses and enhancing collagen synthesis
样品类型: Tissue homogenate - 文献: Exploring the potential of Lacticaseibacillus paracasei M11 on antidiabetic, anti-inflammatory, and ACE inhibitory effects of fermented dromedary camel milk (Camelus dromedaries) and the release of antidiabetic and anti-hypertensive peptides
样品类型: RAW 264.7 cells - 文献: Genistein suppresses microglial activation and inhibits apoptosis in different brain regions of hypoxia-exposed mice model of amnesia
样品类型: Hippocampus tissue - 文献: CDGSH iron sulfur domain 2 mitigates apoptosis, oxidative stress and inflammatory response caused by oxygen–glucose deprivation/reoxygenation in HT22 hippocampal neurons by Akt-Nrf2-activated pathway
样品类型: HT22 neurons - 文献: The inhibition of microRNA-203 on ischemic reperfusion injury after total knee arthroplasty via suppressing MYD88-mdiated toll-like receptor signaling pathway
样品类型: Tissue homogenate - 文献: The osteoimmunomodulatory effect of nanostructured TiF
x
/TiO
x
coating on osteogenesis induction
样品类型: RAW264.7 cells - 文献: IGF2 inhibits hippocampal over-activated microglia and alleviates depression-like behavior in LPS- treated male mice
样品类型: Serum - 文献: Sodium P-aminosalicylic Acid Attenuates Manganese-Induced Neuroinflammation in BV2 Microglia by Modulating NF-κB Pathway
样品类型: Cell culture supernatant(BV2 Cells) - 文献: Borate Ameliorates Sodium Nitrite-Induced Oxidative Stress Through Regulation of Oxidant/Antioxidant Status: Involvement of the Nrf2/HO-1 and NF-κB Pathways
样品类型: Serum - 文献: Inhibition of the mitochondrial complex-1 protects against carbon tetrachloride-induced acute liver injury
样品类型: liver - 文献: Combination of tanshinone IIA and astragaloside IV attenuate atherosclerotic plaque vulnerability in ApoE(-/-) mice by activating PI3K/AKT signaling and suppressing TRL4/NF-κB signaling
样品类型: plasma,RAW264.7 cell - 文献: Pepsin-Soluble Collagen from the Skin of Lophius litulo: A Preliminary Study Evaluating Physicochemical, Antioxidant, and Wound Healing Properties
样品类型: serum - 文献: A sesquiterpene isolated from the stems and leaves of Dioscorea opposita thunb. Transforms the composition of immune cells through ERβ in a mouse model of LPS-induced lung injury
样品类型: Serum,lung tissue,BEAS-2B cell - 文献: 3α-Angeloyloxy-ent-kaur-16-en-19-oic Acid Isolated from Wedelia trilobata L. Alleviates Xylene-Induced Mouse Ear Edema and Inhibits NF-κB and MAPK Pathway in LPS-Stimulated Macrophages
样品类型: Cell culture medium,Tissue Slice - 文献: Suhuang Antitussive Capsules-Ameliorative Effects on LPS-Induced Sputum Obstruction in Mice Through Promoting HGF Secretion
样品类型: Serum,Tissue homogenate - 文献: Adiponectin Inhibits NLRP3 Inflammasome Activation in Nonalcoholic Steatohepatitis via AMPK-JNK/ErK1/2-NFκB/ROS Signaling Pathways
样品类型: Tissue homogenate(liver tissue) - 文献: Blocking PI3K/AKT signaling inhibits bone sclerosis in subchondral bone and attenuates post‐traumatic osteoarthritis
样品类型: serum,preosteoblasts - 文献: Thymosin β10 promotes tumor-associated macrophages M2 conversion and proliferation via the PI3K/Akt pathway in lung adenocarcinoma
样品类型: RAW264.7 cell - 文献: Assessment of novel azaanthraquinone derivatives as potent multi-target inhibitors of inflammation and amyloid-β aggregation in Alzheimer’s disease
样品类型: Cell culture medium - 文献: Saikosaponin-d attenuated lipopolysaccharide-induced depressive-like behaviors via inhibiting microglia activation and neuroinflammation
样品类型: Cell sample,Tissue homogenate - 文献: NLRP12 negatively regulates EtOH-induced liver macrophage activation via NF-κB pathway and mediates hepatocyte apoptosis in alcoholic liver injury
样品类型: serum,RAW 264.7 cell - 文献: Molecular hydrogen attenuates sepsis-induced neuroinflammation through regulation of microglia polarization through an mTOR-autophagy-dependent pathway
样品类型: Tissue homogenate - 文献: miR-129-5p alleviates LPS-induced acute kidney injury via targeting HMGB1/TLRs/NF-kappaB pathway
样品类型: Serum - 文献: Inhibition of HMGB1 involved in the protective of salidroside on liver injury in diabetes mice
样品类型: Cell culture supernatant,Serum,Tissue homogenate - 文献: Didymin ameliorates dexamethasone-induced non-alcoholic fatty liver disease by inhibiting TLR4/NF-κB and PI3K/Akt pathways in C57BL/6J mice
样品类型: Tissue homogenate - 文献: Betulin alleviates on myocardial inflammation in diabetes mice via regulating Siti1/NLRP3/NF-κB pathway
样品类型: serum,heart - 文献: 10-Hydroxydecanoic acid inhibits LPS-induced inflammation by targeting p53 in microglial cells
样品类型: Cell culture supernatant - 文献: Sulfated Galactofucan from Sargassum Thunbergii Attenuates Atherosclerosis by Suppressing Inflammation Via the TLR4/MyD88/NF-κB Signaling Pathway
样品类型: serum,RAW264.7 cells - 文献: Platinum nanoparticles Protect Against Lipopolysaccharide-Induced Inflammation in Microglial BV-2 Cells via Decreased Oxidative Damage and Increased Phagocytosis
样品类型: BV-2 cell - 文献: Latexin deficiency in mice up-regulates inflammation and aggravates colitis through HECTD1/Rps3/NF-κB pathway
样品类型: Serum - 文献: Anti-inflammatory effect of preserved egg with simulated gastrointestinal digestion on LPS-stimulated RAW264.7 cells
样品类型: Cell culture supernatant - 文献: Effect of gap junctions on RAW264.7 macrophages infected with H37Rv
样品类型: Cell culture supernatant - 文献: Role of Brd4 in the production of inflammatory cytokines in mouse macrophages treated with titanium particles
样品类型: Cell culture supernatant - 文献: MicroRNA‐345‐5p regulates depression by targeting suppressor of cytokine signaling 1
样品类型: Cell culture supernatant - 文献: Osthole inhibits proliferation of kainic acid‑activated BV‑2 cells by modulating the Notch signaling pathway
样品类型: Cell culture supernatant - 文献: Coenzyme Q10 alleviates sevoflurane‑induced neuroinflammation by regulating the levels of apolipoprotein E and phosphorylated tau protein in mouse hippocampal neurons
样品类型: Tissue homogenate - 文献: Berberine Attenuates Cigarette Smoke Extract-induced Airway Inflammation in Mice: Involvement of TGF-β1/Smads Signaling Pathway
样品类型: Bronchoalveolar Lavage Fluid - 文献: Synthesis and evaluation of novel D-ring substituted steroidal pyrazolines as potential anti-inflammatory agents
样品类型: Cell culture supernatant - 文献: Atrial Natriuretic Peptide (ANP) Suppress λ-Carrageenan-Induced Acute Paw Edema by Modulating Pro-inflammatory Genes in Swiss Albino Mice
样品类型: paw tissue - 文献: Frequent exposure to varied home cage sizes alters pain sensitivity and some key inflammation-related biomarkers
样品类型: Tissue homogenate - 文献: Ghrelin ameliorates intestinal barrier dysfunction in experimental colitis by inhibiting the activation of nuclear factor-kappa B
样品类型: Tissue homogenate - 文献: Death-associated protein kinase 1 correlates with podocyte apoptosis and renal damage and can be mediated by miR-361.
样品类型: renal podocytes - 文献: Notch signalling regulates steroidogenesis in mouse ovarian granulosa cells
样品类型: Cell culture medium - 文献: Aerobic exercise alleviates ventilator-induced lung injury by inhibiting NLRP3 inflammasome activation
样品类型: Bronchoalveolar lavage fluid (BALF) - 文献: Plasmodium knowlesi Duffy binding protein alpha region II (PkDBPαII) in clinical isolates from Peninsular Malaysia and Malaysian Borneo exhibit different immune responses in animal models
样品类型: Spleen cell - 文献: Effect and mechanism of citral against methicillin‐resistant Staphylococcus aureus in vivo
样品类型: Serum - 文献: LincRNA‑EPS increases TGF‑β expression to inhibit the Wnt/β‑catenin pathway, VSMC osteoblastic differentiation and vascular calcification in diabetic mice
样品类型: serum - 文献: Clostridium butyricum protects intestinal barrier function via upregulation of tight junction proteins and activation of the Akt/mTOR signaling pathway in a mouse model of dextran sodium sulfate‑induced colitis
样品类型: Serum - 文献: The intervention mechanism of emodin on TLR3 pathway in the process of central nervous system injury caused by herpes virus infection
样品类型: Tissue homogenate - 文献: Upregulation of BRD7 protects podocytes against high glucose-induced apoptosis by enhancing Nrf2 in a GSK-3β-dependent manner
样品类型: MPC-5 cell - 文献: Isolation, characterization and anti-inflammatory mechanism of probiotics in lipopolysaccharide-stimulated RAW 264.7 macrophages
样品类型: RAW 264.7 cell - 文献: Association of IL-6, IL-8, MMP-13 gene polymorphisms with knee osteoarthritis susceptibility in the Chinese Han population
样品类型: Tissue homogenate - 文献: Eosinophils attenuate arthritis by inducing M2 macrophage polarization via inhibiting the IκB/P38 MAPK signaling pathway
样品类型: Tissue homogenate,Cell culture supernatant - 文献: Metabolites of stable fly reduce diarrhea in mice by modulating the immune system, antioxidants, and composition of gut microbiota
样品类型: serum,small intestinal tissues - 文献: Upregulated TSG-6 Expression in ADSCs Inhibits the BV2 Microglia-Mediated Inflammatory Response
样品类型: BV2 cells - 文献: MiRNA-182-5p aggravates experimental ulcerative colitis via sponging Claudin-2
样品类型: colonic tissue - 文献: Camelina sativa Oil Treatment Alleviates Castor Oil-Induced Diarrhea in ICR Mice by Regulating Intestinal Flora Composition
样品类型: plasma - 文献: IL-37 alleviates alveolar bone resorption and inflammatory response through the NF-κB/NLRP3 signaling pathway in male mice with periodontitis
样品类型: periodontal tissue - 文献: Febuxostat Alleviates Allergic Rhinitis by Inhibiting Inflammation and Monocyte Adhesion in Human Nasal Epithelial Cells via Regulating KLF6.
样品类型: nasal mucosa tissue - 文献: Exploring the Muscle Metabolomics in the Mouse Model of Sepsis-Induced Acquired Weakness
样品类型: serum - 文献: Anti-inflammatory Mechanism of Action of Benzoylmesaconine in Lipopolysaccharide-Stimulated RAW264.7 Cells
样品类型: RAW264.7 cell - 文献: Synthesis and anti-inflammatory activity of novel steroidal chalcones with 3β-pregnenolone ester derivatives in RAW 264.7 cells in vitro
样品类型: Cell culture supernatant - 文献: Chrysosplenol D protects mice against LPS-induced acute lung injury by inhibiting oxidative stress, inflammation, and apoptosis via TLR4-MAPKs/NF-κB signaling pathways:
样品类型: Bronchoalveolar Lavage Fluid - 文献: Corilagin potential in inhibiting oxidative and inflammatory stress in LPS-induced murine macrophage cell lines (RAW 264.7)
样品类型: RAW 264.7 cell - 文献: The immune-enhancing effect and in vitro antioxidant ability of different fractions separated from Colla corii asini
样品类型: RAW 264.7 cell - 文献: Impact of Thymus vulgaris extract on sodium nitrite-induced alteration of renal redox and oxidative stress: Biochemical, molecular, and immunohistochemical study
样品类型: Serum,Tissue homogenate(kidney) - 文献: Buchholzia coriacea seed (wonderful kolanut) alleviates insulin resistance, steatosis, inflammation and oxidative stress in high fat diet model of fatty liver disease
样品类型: plasma - 文献: Broccoli microgreens have hypoglycemic effect by improving blood lipid and inflammatory factors while modulating gut microbiota in mice with type 2 diabetes
样品类型: serum - 文献: The Berberis vulgaris L. extract berberine exerts its anti-oxidant effects to ameliorate cholesterol overloading–induced cell apoptosis in the primary mice hepatocytes: an in vitro study
样品类型: serum - 文献: Hace1 overexpression mitigates myocardial hypoxia/reoxygenation injury via the effects on Keap1/Nrf2 pathway
样品类型: Primary cardiac cells - 文献: MiR-18a-3p improves cartilage matrix remodeling and inhibits inflammation in osteoarthritis by suppressing PDP1
样品类型: ATDC5 cell - 文献: miR-124/MCP-1 signaling pathway modulates the protective effect of itraconazole on acute kidney injury in a mouse model of disseminated candidiasis
样品类型: serum - 文献: Therapeutic effect of imiquimod on dextran sulfate sodium-induced ulcerative colitis in mice
样品类型: Serum - 文献: Chronic administration of mitochondrion-targeted peptide SS-31 prevents atherosclerotic development in ApoE knockout mice fed Western diet
样品类型: Serum - 文献: 4-Hydroxyisoleucine relieves inflammation through iRhom2-dependent pathway in co-cultured macrophages and adipocytes with LPS stimulation
样品类型: Cell sample - 文献: Isomangiferin Attenuates Renal Injury in Diabetic Mice via Inhibiting Inflammation
样品类型: Serum,Tissue homogenate - 文献: Capparis spinosa Fruit Ethanol Extracts Exert Different Effects on the Maturation of Dendritic Cells
样品类型: Cell culture supernatant - 文献: GLP-1R activation ameliorated novel-object recognition memory dysfunction via regulating hippocampal AMPK/NF-κB pathway in neuropathic pain mice
样品类型: Tissue homogenate(hippocampus) - 文献: Structure elucidation and anti-inflammatory mechanism of difengpienol C, a new neolignan isolated from Illicium difengpi
样品类型: RAW264.7 cells - 文献: MiR-590-3p Attenuates Acute Kidney Injury by Inhibiting Tumor Necrosis Factor Receptor-Associated Factor 6 in Septic Mice
样品类型: Serum - 文献: Attenuation of Inflammation and Oxidative Stress in High-Fat-Diet-Induced Obese Mice
样品类型: Tissue homogenate - 文献: Maggot protein ameliorates dextran sulphate sodium-induced ulcerative colitis in mice
样品类型: Serum - 文献: Neurotoxic 18-kDa apolipoprotein E fragment production contributes to anesthetic sevoflurane-induced tau phosphorylation and neuroinflammation in vitro:
样品类型: neurons - 文献: Curcumin ameliorates Staphylococcus aureus-induced mastitis injury through attenuating TLR2-mediated NF−κB activation
样品类型: Serum - 文献: Protective effects of SKLB023 on a mouse model of unilateral ureteral obstruction by the modulation of gut microbiota
样品类型: plasma - 文献: Sinomenine Attenuates Cartilage Degeneration by Regulating miR-223-3p/NLRP3 Inflammasome Signaling
样品类型: Serum,Cell culture supernatant - 文献: Atractylon treatment prevents sleep-disordered breathing-induced cognitive dysfunction by suppression of chronic intermittent hypoxia-induced M1 microglial activation
样品类型: Cell culture supernatant - 文献: α‑rhamnrtin‑3‑α‑rhamnoside exerts anti‑inflammatory effects on lipopolysaccharide‑stimulated RAW264.7 cells by abrogating NF‑κB and activating the Nrf2 signaling pathway
样品类型: RAW264.7 cell - 文献: BCG stimulation promotes dendritic cell proliferation and expression of VDR and CYP27B1 in vitamin D‑deficient mice
样品类型: BMDCs - 文献: Astaxanthin suppresses lipopolysaccharide‑induced myocardial injury by regulating MAPK and PI3K/AKT/mTOR/GSK3β signaling
样品类型: Serum - 文献: Wogonin attenuates inflammation by activating PPAR-γ in alcoholic liver disease
样品类型: Serum,Cell culture supernatant - 文献: Gastrodin attenuates neuroinflammation in DOI‐induce Tourette syndrome in rats
样品类型: Serum,Tissue homogenate - 文献: Glucosylceramide synthase regulates hepatocyte repair after concanavalin A-induced immune-mediated liver injury
样品类型: serum - 文献: 3,4-dihydroxyphenylethyl alcohol glycoside reduces acetaminophen-induced acute liver failure in mice by inhibiting hepatocyte ferroptosis and pyroptosis
样品类型: plasma - 文献: A Novel Hepatectomy Model in Mice Using a Gutta Cutter Tool: A Feasibility Study and Preliminary Results
样品类型: serum - 文献: The TrkB agonist 7,8-dihydroxyflavone improves sensory-motor performance and reduces lipid peroxidation in old mice.
样品类型: cortex - 文献: Human umbilical cord mesenchymal stem cells suppress lung cancer via TLR4/NF-κB signalling pathway
样品类型: Lewis cell-xenograft - 文献: Role of Interleukin 17A in Aortic Valve Inflammation in Apolipoprotein E-deficient Mice
样品类型: Plasma - 文献: Sulfated modification promotes the immunomodulatory bioactivities of Lyciumbarbarum polysaccharides in vitro
样品类型: lymphocyte - 文献: The therapeutic effects of resveratrol on hepatic steatosis in high-fat diet-induced obese mice by improving oxidative stress, inflammation and lipid-related gene transcriptional expression
样品类型: Serum,Tissue homogenate - 文献: An experimental hyperlipidemia model with periodontitis in mice
样品类型: serum - 文献: miR‑148a inhibits pro‑inflammatory cytokines released by intervertebral disc cells by regulating the p38/MAPK pathway
样品类型: Cell culture supernatant - 文献: Enriched environment during adolescence modulates lipid metabolism and emotion-related behaviors in mice
样品类型: serum - 文献: Chemerin-9 Peptide Enhances Memory and Ameliorates Aβ1-42-induced Object Memory Impairment in Mice
样品类型: hippocampus - 文献: The association between inflammation, the microbiome and urethane-induced pulmonary adenocarcinoma Corrigendum in /10.3892/ol.2018.9063
样品类型: Serum - 文献: Bone marrow mesenchymal stem cells accelerate the hyperglycemic refractory wound healing by inhibiting an excessive inflammatory response
样品类型: Skin tissue - 文献: Subcutaneous administration of casein attenuates atherosclerotic progression in male apoE-/- mice fed with high-fat diet
样品类型: Plasma - 文献: Antioxidant and Anti-Inflammatory Activities of Kigelia africana (Lam.) Benth.
样品类型: RAW 264.7 cell - 文献: Synergistic protection of matrine and lycopene against lipopolysaccharide‑induced acute lung injury in mice
样品类型: lung - 文献: Kisspeptin‑13 inhibits bleomycin‑induced pulmonary fibrosis through GPR54 in mice
样品类型: lung - 文献: Adipose-Derived Stem Cells-Derived Exosomes with High Amounts of Circ_0001747 Alleviate Hypoxia/Reoxygenation-Induced Injury in Myocardial Cells by Targeting MiR-199b-3p/MCL1 Axis
样品类型: HL-1 cell - 文献: Effects of Simulated Heat Wave and Ozone on High Fat Diet ApoE Deficient Mice
样品类型: Plasma,Tissue homogenate - 文献: The Effects of RKI-1447 in a Mouse Model of Nonalcoholic Fatty Liver Disease Induced by a High-Fat Diet and in HepG2 Human Hepatocellular Carcinoma Cells Treated with Oleic Acid
样品类型: Serum,Cell culture supernatant,Tissue homogenate - 文献: Oral supplementation with ursolic acid ameliorates sepsis-induced acute kidney injury in a mouse model by inhibiting oxidative stress and inflammatory responses
样品类型: Serum - 文献: Embelin inhibits abdominal aortic aneurysm through decreasing IL‑6‑induced STAT3 and NF‑κB inactivation
样品类型: Aortic tissues - 文献: Dioscin prevents LPS‑induced acute lung injury through inhibiting the TLR4/MyD88 signaling pathway via upregulation of HSP70
样品类型: Serum,Tissue homogenate - 文献: Protective effects on acute hypoxic-ischemic brain damage in mfat-1 transgenic mice by alleviating neuroinflammation
样品类型: brain tissue - 文献: Neuroprotective effect of Mulmina™ against chemotherapy‑induced cognitive decline in normal mice Erratum in /10.3892/br.2021.1433
样品类型: brain - 文献: Golden sea cucumber extract revives glucose transporter-4 and interleukin-6 protein level in diabetic mouse muscle
样品类型: Tissue homogenate - 文献: Crocin Suppresses Inflammation-Induced Apoptosis in rmTBI Mouse Model Via Modulation of Nrf2 Transcriptional Activity
样品类型: brain cortex - 文献: Antihypernociceptive, Anxiolytic, and Antidepressant Properties of Aqueous and Ethanol Extracts of Dissotis thollonii Cogn. (Melastomataceae) in Mice
样品类型: Serum,Tissue homogenate - 文献: Effect of ganoderic acid on diethylnitrosamine-induced liver cancer in mice
样品类型: serum - 文献: Antioxidant and anti-inflammatory effects of an ethanol fraction from the Schisandra chinensis baillon hot water extract fermented using Lactobacilius paracasei subsp. tolerans
样品类型: RAW 264.7 cells - 文献: A Comparative Study of the Effects upon LPS Induced Macrophage RAW264.7 Inflammation in vitro of the Lipids of Hippocampus trimaculatus Leach
样品类型: Cell culture supernatant
