MT3 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-15198
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | GIF,GIFB,GRIF,Growth inhibitory factor,Metallothionein 3 (growth inhibitory factor (neurotrophic)),Metallothionein 3,Metallothionein III,Metallothionein-3,Metallothionein-III,Mt 3,MT III,MT-3,MT-III,MT3,MT3,ZnMT3,MT3抗体 |
| Swissprot | P25713 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein of human MT3 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 0.5 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoskeleton,microtubule,Cytosol,Endoplasmic reticulum,rough endoplasmic reticulum,Extracellular region or secreted,extracellular space,Mitochondrion,mitochondrial outer membrane,Plasma Membrane,Other locations:astrocyte end-foot,axon,cytoplasm,dendritic spine,inclusion body,intracellular,perinuclear region of cytoplasm,postsynaptic density,ribosome,synaptic vesicle |
| Tissue specificity | Abundant in a subset of astrocytes in the normal human brain, but greatly reduced in the Alzheimer disease (AD) brain. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | Metallothionein (MT) is a sulfhydryl- and cysteine-rich protein found in micro-organisms, plants and all invertebrate and vertebrate animals. Metallothioneins are a group of ubiquitous low-molecular-weight proteins that have functional roles in cell growth, repair and differentiation. Metallothionein are implicated primarily in metal ion detoxification as they are essential for the protection of cells against the toxicity of cadmium, mercury and copper. Metallothioneins are known to be broadly expressed in heart, liver, kidney, breast and testis tissue. Metallothionein 3, also known as MT-3 or GIFB (growth inhibitory factor), is a 68 amino acid protein that belongs to the type 1 family and Metallothionein superfamily. While highly expressed in astrocytes of the normal human brain, Metallothionein 3 expression is reduced in the brains of patients with Alzheimer disease. |
