NDRG1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-15993
宿主: Rabbit
反应性: H,M,R
应用: WB,IHC
Overview
| Synonyms | 42 kDa,Anti GC4,cap43,cmt4d,Differentiation related gene1 protein,Differentiation-related gene 1 protein,Drg 1,DRG-1,drg1,gc4,GC4,hmsnl,Human mRNA for RTP complete cds,N myc downstream regulated gene 1,N myc downstream regulated gene 1 protein,N-myc downstream-regulated gene 1 protein,Ndr 1,ndr1,NDRG 1,Ndrg1,NDRG1 protein,NDRG1,Nickel specific induction protein,Nickel specific induction protein Cap43,Nickel-specific induction protein Cap43,nmsl,Nmyc downstream regulated,Nmyc downstream regulated gene1,Nmyc downstream regulated gene1 protein,Protein NDRG1,Protein regulated by oxygen 1,Protein regulated by oxygen1,Proxy1,Reduced in tumor,Reducin,Reducing agents and tunicamycin responsive protein,Reducing agents and tunicamycin-responsive protein,Rit42,RTP,targ1,TDD5,tdds,Tunicamycin responsive protein,NDRG1抗体 |
| Swissprot | Q92597 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic peptide of human NDRG1 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:50-1:200; |
| Concentration | 0.6 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Nucleus. Cell membrane. Whereas in prostate epithelium and placental chorion it is located in both the cytoplasm and the nucleus, nuclear staining is not observed in colon epithelium cells. Instead its localization changes from the cytoplasm to the plasma membrane during differentiation of colon carcinoma cell lines in vitro. |
| Tissue specificity | Ubiquitous; expressed most prominently in placental membranes and prostate, kidney, small intestine, and ovary tissues. Reduced expression in adenocarcinomas compared to normal tissues. In colon, prostate and placental membranes, the cells that border the lumen show the highest expression. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
Images
Western Blot analysis of Human lymphoma tissue using NDRG1 Polyclonal Antibody at dilution of 1:1000
Immunohistochemistry of paraffin-embedded Human brain using NDRG1 Polyclonal Antibody at dilution of 1:70
Immunohistochemistry of paraffin-embedded Human esophagus cancer using NDRG1 Polyclonal Antibody at dilution of 1:70
