NEDD9 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-15091
宿主: Rabbit
反应性: H
应用: WB
Overview
| Synonyms | Cas like docking,Cas scaffolding protein family member 2,CAS-L,CAS2,CasL,CASL,CASS2,Crk associated substrate related,Crk associated substrate related protein,CRK-associated substrate-related protein,dJ49G10.2 (Enhancer of Filamentation 1 (HEF1)),dJ49G10.2,dJ761I2.1 (enhancer of filamentation (HEF1)),dJ761I2.1,Enhancer of filamentation 1,Enhancer of filamentation 1 p55,HEF 1,HEF1,NEDD-9,Nedd9,Neural precursor cell expressed developmentally down-regulated protein 9,P105,Renal carcinoma antigen NY-REN-12,NEDD9抗体 |
| Swissprot | Q14511 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Recombinant protein of human NEDD9 |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:200-1:1000; |
| Concentration | 0.4 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm>cytoskeleton>spindle and Cytoplasm>cell cortex. Nucleus. Golgi apparatus. Cell projection>lamellipodium. Cytoplasm. Cell junction>focal adhesion. Localizes to both the cell nucleus and the cell periphery and is differently localized in fibroblasts and epithelial cells. In fibroblasts is predominantly nuclear and in some cells is present in the Golgi apparatus. In epithelial cells localized predominantly in the cell periphery with particular concentration in lamellipodia but is also found in the nucleus. Isoforms p105 and p115 are predominantly cytoplasmic and associate with focal adhesions while p55 associates with mitotic spindle. |
| Tissue specificity | Widely expressed. Higher levels detected in kidney, lung, and placenta. Also detected in T-cells, B-cells and diverse cell lines. The protein has been detected in lymphocytes, in diverse cell lines, and in lung tissues. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported to have a role in cancer metastasis. Alternative splicing results in multiple transcript variants. |
