NFATC3 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-14243
宿主: Rabbit
反应性: H,M
应用: IHC
Overview
| Synonyms | C80703,cytoplasmic 3,D8Ertd281e,NF AT4,NF ATc3,NF-AT4,NF-ATc3,NFAC3,NFATc3,NFATx,Nuclear factor of activated T cells,cytoplasmic 3,nuclear factor of activated T cells,cytoplasmic,calcineurin dependent 3,Nuclear factor of activated T-cells,T cell transcription factor NFAT4,T-cell transcription factor NFAT4,NFATC3抗体 |
| Swissprot | Q12968 |
| Source | Rabbit |
| Reactivity | Human,Mouse |
| Immunogen | Recombinant protein of human NFATC3 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:100-1:300 |
| Concentration | 0.7 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Nucleus. Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription. |
| Tissue specificity | Isoform 1 is predominantly expressed in thymus and is also found in peripheral blood leukocytes and kidney. Isoform 2 is predominantly expressed in skeletal muscle and is also found in thymus, kidney, testis, spleen, prostate, ovary, small intestine, heart, placenta and pancreas. Isoform 3 is expressed in thymus and kidney. Isoform 4 is expressed in thymus and skeletal muscle. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex.This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component.Other members of this family participate to form this complex also.The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes.Several transcript variants encoding distinct isoforms have been identified for this gene. |
