NFKB1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-52132
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | DKFZp686C01211,DNA binding factor KBF1,DNA binding factor KBF1 EBP1,DNA-binding factor KBF1,EBP 1,EBP-1,EBP1,KBF1,MGC54151,nf b,NF kappa B,NF kappaB,NF kappabeta,NF kB1,NFkappaB,NFKB 1,NFKB p105,NFKB p50,Nfkb1,NFKB1,Nuclear factor kappa B DNA binding subunit,Nuclear factor kappa-B,subunit 1,Nuclear factor NF kappa B p105 subunit,Nuclear factor NF kappa B p50 subunit,Nuclear factor NF-kappa-B p50 subunit,Nuclear factor of kappa light chain gene enhancer in B cells 1,Nuclear factor of kappa light polypeptide gene enhancer in B cells 1,Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1,p105,p50,p84/NF-kappa-B1 p98,Transcription factor NFKB1,NFKB1抗体 |
| Swissprot | P19838 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Fusion protein of human NFKB1 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 0.84mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus. Cytoplasm. Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene. |
