PAPPA Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-13489
宿主: Rabbit
反应性: H,M
应用: IHC
Overview
| Synonyms | ASBABP2,Aspecific BCL2 ARE binding protein 2,Differentially placenta 1 expressed protein,DIPLA1,EC 3.4.24.79,IGF dependent IGFBP 4 protease,IGF-dependent IGFBP-4 protease,IGFBP 4ase,IGFBP-4ase,IGFBP4ase,Insulin like growth factor dependent IGF binding protein 4 protease,Insulin-like growth factor-dependent IGF-binding protein 4 protease,PAPA,PAPP A,PAPP-A,PAPP1,PAPPA,PAPPA1,Pappalysin 1 precursor,Pappalysin-1,Pregnancy Associated Plasma Protein A,Pregnancy associated plasma protein A pappalysin 1,Pregnancy-associated plasma protein A,PAPPA抗体 |
| Swissprot | Q13219 |
| Source | Rabbit |
| Reactivity | Human,Mouse |
| Immunogen | Synthetic peptide of human PAPPA |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 0.4 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Secreted. |
| Tissue specificity | High levels in placenta and pregnancy serum. In placenta, expressed in X cells in septa and anchoring villi, and in syncytiotrophoblasts in the chorionic villi. Lower levels are found in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow, colon, fibroblasts and osteoblasts. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. |
Images
Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PAPPA Polyclonal Antibody at dilution of 1:50
Immunohistochemistry of paraffin-embedded Human thyroid cancer using PAPPA Polyclonal Antibody at dilution of 1:50
Immunohistochemistry of paraffin-embedded Human Placenta using PAPPA Polyclonal Antibody at dilution of 1:100(Elabscience® Product Detected by Lifespan).
