PARD3 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-40193
宿主: Rabbit
反应性: R
应用: WB
Overview
| Synonyms | agouti signaling protein,ASIP,Atypical PKC isotype specific interacting protein,Atypical PKC isotype-specific-interacting protein,Baz,bazooka,Coagulation factor II receptor-like 2,CTCL tumor antigen se2-5,F2rl2,PAR-3,par-3 family cell polarity regulator alpha,par-3 family cell polarity regulator,PAR3 alpha,par3,PAR3-alpha,PARD-3,Pard3,PARD3,PARD3A,Partitioning defective 3 homolog,Partitioning-defective 3 homolog,Partitioning-defective protein 3,C. elegans,homolog of,SE2-5L16,SE2-5LT1,SE2-5T2,Thrombin receptor-like 2,PARD3A抗体 |
| Swissprot | Q9Z340 |
| Source | Rabbit |
| Reactivity | Rat |
| Immunogen | Recombinant Rat Partitioning defective 3 homolog protein |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:500-1:2000; |
| Concentration | 2mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Endomembrane system. Cell junction. Cell junction>tight junction. Cell membrane. Cytoplasm>cell cortex. Cytoplasm>cytoskeleton. Localized along the cell-cell contact region. Colocalizes with PARD6A and PRKCI at epithelial tight junctions. Colocalizes with the cortical actin that overlays the meiotic spindle during metaphase I and metaphase II (By similarity). Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction. |
| Tissue specificity | Widely expressed. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,1% protective protein and 50% glycerol,pH7.4 |
| Background | This gene encodes a member of the PARD protein family. PARD family members interact with other PARD family members and other proteins; they affect asymmetrical cell division and direct polarized cell growth. Multiple alternatively spliced transcript variants have been described for this gene.PARD3 (Par-3 Family Cell Polarity Regulator) is a Protein Coding gene. Diseases associated with PARD3 include Gamma Heavy Chain Disease and Enamel Caries. Among its related pathways are Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer and Ras signaling pathway. GO annotations related to this gene include protein phosphatase binding and phosphatidylinositol-4,5-bisphosphate binding. An important paralog of this gene is PARD3B. |
