PARD6A Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-10525
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | 0710008C04Rik,2610010A15Rik,Par 6 partitioning defective 6 C elegans homolog alpha,Par 6 partitioning defective 6 homolog alpha,Par 6 partitioning defective 6 homolog alpha C elegans,PAR 6A,PAR-6 alpha,PAR-6,par-6 family cell polarity regulator alpha,PAR-6A,PAR6,PAR6A,PAR6alpha,PAR6C,Pard6a,Partitioning defective 6 homolog alpha,partitioning-defective protein 6,partitioning-defective protein 6, C. elegans,homolog of,alpha,Tax interacting protein 40,Tax interaction protein 40,TAX40,TIP 40,TIP-40,TIP40,PARD6A抗体 |
| Swissprot | Q9NPB6 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein of human PARD6A |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 0.5 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Cell membrane. Cell projection>ruffle. Cell junction>tight junction. Colocalizes with GTP-bound CDC42 or RAC1 at membrane ruffles and with PARD3 and PRKCI at epithelial tight junctions. |
| Tissue specificity | Expressed in pancreas, skeletal muscle, brain and heart. Weakly expressed in kidney and placenta. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. |
