Phospho-FLNA (Ser2152) Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL |
| 价格： | / ￥630 / ￥1510 / ￥2415 |
货号：E-AB-21143
宿主: Rabbit
反应性: H,M,R,Mk
应用: WB,IHC-p
Overview
| Synonyms | ABP 280,ABP-280,Actin-binding protein 280,Alpha filamin,Alpha-filamin,APBX,CSBS,CVD1,Endothelial actin binding protein,Endothelial actin-binding protein,Filamin 1,Filamin A alpha,Filamin A,Filamin-1,Filamin-A,FLN,FLN-A,FLN1,FLNA,FLNA,FMD,MNS,NHBP,Non muscle filamin,Non-muscle filamin,OPD,OPD1,OPD2,XLVD,XMVD,Filamin 1 (phospho Ser2152)磷酸化抗体 |
| Swissprot | P21333 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat,Monkey |
| Immunogen | Synthesized peptide derived from human Filamin 1 around the phosphorylation site of Ser2152 |
| Application | WB(Detection kit: E-IR-R304),IHC-p(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:100-1:300; |
| Concentration | 1mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm>cell cortex. Cytoplasm>cytoskeleton. |
| Tissue specificity | Ubiquitous. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4 |
| Background | The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene. |
