Phospho-STAT3 (Tyr705) Monoclonal Antibody
| 规格： | / 20μL / 60μL / 120μL |
| 价格： | / ￥630 / ￥1510 / ￥2415 |
货号：E-AB-51040
宿主: Mouse
反应性: H
应用: IHC-p
Overview
| Synonyms | 1110034C02Rik,Acute Phase Response Factor,Acute-phase response factor,ADMIO,APRF,AW109958,DNA binding protein APRF,FLJ20882,HIES,MGC16063,Signal transducer and activator of transcription 3 (acute phase response factor),Signal transducer and activator of transcription 3,STAT 3,Stat3,STAT3,Phospho-Stat3 (Y705) Mouse (1E9)磷酸化抗体 |
| Swissprot | P40763 |
| Source | Mouse |
| Reactivity | Human |
| Immunogen | Synthetic Peptide of Phospho-Stat3 (Y705) |
| Application | IHC-p(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:100-200 |
| Concentration | 1mg/mL |
| Clonality | Monoclonal |
Properties
| Cellular localization | Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1. |
| Tissue specificity | Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. |
| Clone No | Clone:1E9 |
|---|---|
| Isotype | IgG |
| Purification | Protein A purification |
| Conjugation | Phospho-Stat3 (Y705) Mouse Monoclonal Antibody |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4. |
| Background | Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214). |
