PI 3 kinase p85 alpha Polyclonal Antibody
| 规格： | / 60μL / 120μL / 200μL |
| 价格： | / ￥1380 / ￥2220 / ￥3300 |
货号：E-AB-70381
宿主: Rabbit
反应性: H,M,R
应用: WB
Overview
| Synonyms | GRB1,p85 alpha,p85,P85A,Phosphatidylinositol 3 kinase associated p 85 alpha,Phosphatidylinositol 3 kinase regulatory 1,Phosphatidylinositol 3 kinase,regulatory subunit,polypeptide 1 (p85 alpha),Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha,Phosphatidylinositol 3-kinase regulatory subunit alpha,Phosphoinositide 3 kinase,regulatory subunit 1 (alpha),PI3 kinase p85 subunit alpha,PI3-kinase regulatory subunit alpha,PI3-kinase subunit p85-alpha,PI3K,PI3K regulatory subunit alpha,Pik3r1,PtdIns 3 kinase p85 alpha,PtdIns-3-kinase regulatory subunit alpha,PtdIns-3-kinase regulatory subunit p85-alpha,PI 3 kinase p85 alpha抗体 |
| Swissprot | P27986,P26450,Q63787 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein corresponding to Human PI 3 Kinase p85 alpha. |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:500-1:2000; |
| Concentration | 1.6 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytosol,Endoplasmic reticulum,perinuclear endoplasmic reticulum membrane,Nucleus,Plasma Membrane,Other locations:cell-cell junction,cis-Golgi network,cytoplasm,membrane,phosphatidylinositol 3-kinase complex,phosphatidylinositol 3-kinase complex, class IA,protein complex |
| Tissue specificity | The P85-alpha isoform is widely expressed. Expression of the P55-alpha isoform is Highest in brain and skeletal muscle. The P50-alpha isoform is abundant in liver with lower levels in brain and muscle.Highest expression level in brown adipose tissue. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
| Background | Phosphatidylinositol 3-kinase (PI3K) plays an important role in the metabolic actions of insulin and is required for adipogenesis. The PI3K pathway has also been identified as an important player in cancer development and progression. The Class IA PI3K heterodimer,which is composed of a P110 catalytic subunit and a P85 regulatory subunit,is activated upon association of the P85 subunit with upstream adaptor proteins or receptor tyrosine kinases. Mutations in PIK3R1 are implicated in cases of breast cancer and associated to SHORT syndrome. |
