PIAS2 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-13005
宿主: Rabbit
反应性: H,M
应用: IHC
Overview
| Synonyms | Androgen receptor interacting protein 3,Androgen receptor-interacting protein 3,ARIP3,DAB2 interacting protein,DAB2-interacting protein,DIP,E3 SUMO protein ligase PIAS2,E3 SUMO-protein ligase PIAS2,MIZ,Miz1,Msx interacting zinc finger protein,Msx-interacting zinc finger protein,PIAS NY protein,PIAS-NY protein,PIAS2,PIAS2,PIASX,PIASX-ALPHA,PIASX-BETA,Protein inhibitor of activated STAT x,Protein inhibitor of activated STAT,2,Protein inhibitor of activated STAT2,SIZ2,Zinc finger,MIZ-type containing 4,ZMIZ4,PIAS2抗体 |
| Swissprot | O75928 |
| Source | Rabbit |
| Reactivity | Human,Mouse |
| Immunogen | Synthetic peptide of human PIAS2 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 0.6 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus speckle. Nucleus, PML body. Nucleus. Colocalizes at least partially with promyelocytic leukemia nuclear bodies (PML NBs) (PubMed:22406621). Colocalizes with SUMO1 in nuclear granules (By similarity). |
| Tissue specificity | Mainly expressed in testis. Isoform 3 is expressed predominantly in adult testis, weakly in pancreas, embryonic testis and sperm, and at very low levels in other organs. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family.PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins.Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor.A pseudogene of this gene is located on the short arm of chromosome 4.The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. |
