PPM1D Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-52172
宿主: Rabbit
反应性: H,M
应用: IHC
Overview
| Synonyms | EC 3.1.3.16,p53 induced protein phosphatase 1,p53-induced protein phosphatase 1,PP2C delta,PP2C-delta,PP2CD,Ppm1d,PPM1D,Protein phosphatase 1D,protein phosphatase 1D magnesium-dependent delta isoform ,Protein phosphatase 2C delta isoform,Protein phosphatase 2C isoform delta,Protein phosphatase magnesium dependent 1 delta,Protein phosphatase magnesium-dependent 1 delta,Protein phosphatase Mg2+/Mn2+ dependent 1D,Protein phosphatase Wip1,Wild type p53 induced phosphatase 1,WIP 1,WIP1,PPM1D抗体 |
| Swissprot | O15297 |
| Source | Rabbit |
| Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human PPM1D |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:300 |
| Concentration | 0.5mg/mL |
| Clonality | Polyclonal |
Properties
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. |
