PPP1R12A Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-11418
宿主: Rabbit
反应性: H,M,R
应用: WB
Overview
| Synonyms | M130,MBS,Myosin binding subunit,Myosin phosphatase target subunit 1,Myosin phosphatase targeting subunit 1,Myosin phosphatase-targeting subunit 1,MYPT1,MYPT1,PPP1R12A,Protein phosphatase 1 regulatory inhibitor subunit 12A,Protein phosphatase 1 regulatory subunit 12A,Protein phosphatase 1,regulatory (inhibitor) subunit 12A,Protein phosphatase myosin binding subunit,Protein phosphatase myosin-binding subunit,PPP1R12A抗体 |
| Swissprot | O14974 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein of human PPP1R12A |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:200-1:1000; |
| Concentration | 0.4 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Along actomyosin filaments and stress fibers. |
| Tissue specificity | Expressed in striated muscles, specifically in type 2a fibers (at protein level). |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. |
