PRKAR1B Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-12841
宿主: Rabbit
反应性: H,M,R
应用: WB,IHC
Overview
| Synonyms | cAMP dependent protein kinase type I beta regulatory subunit,cAMP-dependent protein kinase type I-beta regulatory subunit,KAP1,PKARI beta,PRKAR 1,PRKAR 1B,PRKAR1,Prkar1b,PRKAR1B protein,Protein kinase cAMP dependent regulatory type I beta,RIbeta,PRKAR1B抗体 |
| Swissprot | P31321 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic peptide of human PRKAR1B |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:1000-1:5000;IHC,,1:50-1:200; |
| Concentration | 0.9 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytosol,Plasma Membrane,Other locations:cAMP-dependent protein kinase complex,ciliary base |
| Tissue specificity | Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | Cyclic AMP-dependent protein kinase A (PKA) is an essential enzyme in the signaling pathway of the second messenger cAMP. Through phosphorylation of target proteins, PKA controls many biochemical events in the cell including regulation of metabolism, ion transport, and gene transcription. The PKA holoenzyme is composed of 2 regulatory and 2 catalytic subunits and dissociates from the regulatory subunits upon binding of cAMP. |
Images
Western Blot analysis of Human colon cancer tissue using PRKAR1B Polyclonal Antibody at dilution of 1:1200
Immunohistochemistry of paraffin-embedded Human breast cancer using PRKAR1B Polyclonal Antibody at dilution of 1:70
Immunohistochemistry of paraffin-embedded Human lung cancer using PRKAR1B Polyclonal Antibody at dilution of 1:70
