PRKAR2A Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-52196
宿主: Rabbit
反应性: H
应用: WB,IHC
Overview
| Synonyms | cAMP dependent protein kinase regulatory subunit alpha 2,cAMP dependent protein kinase regulatory subunit RII alpha,cAMP dependent protein kinase type II alpha regulatory chain,cAMP dependent protein kinase type II alpha regulatory subunit,cAMP-dependent protein kinase type II-alpha regulatory subunit,KAP2,KAP2,MGC3606,PKR 2,PKR2,PRKA R2,PRKAR 2,PRKAR2,PRKAR2A,Protein kinase A RII alpha subunit,Protein kinase cAMP dependent regulatory type II alpha,PRKAR2A抗体 |
| Swissprot | P13861 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Fusion protein of human PRKAR2A |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:35-1:200; |
| Concentration | 0.8mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Cell membrane. Colocalizes with PJA2 in the cytoplasm and the cell membrane. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). |
Images
Western blot analysis of HEPG2 cell and Human testis tissue lysates using PRKAR2A Polyclonal Antibody at dilution of 1:550
Immunohistochemistry of paraffin-embedded Human breast cancer tissue using PRKAR2A Polyclonal Antibody at dilution of 1:50(×200)
Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PRKAR2A Polyclonal Antibody at dilution of 1:50(×200)
