PSMD12 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-18838
宿主: Rabbit
反应性: H,M,R
应用: WB,IHC
Overview
| Synonyms | 26S proteasome non-ATPase regulatory subunit 12,26S proteasome regulatory subunit p55,26S proteasome regulatory subunit RPN5,MGC75406,p55,proteasome (prosome,macropain) 26S subunit,non ATPase12,Proteasome 26S non ATPase subunit 12 isoform 2,PSD12,PSMD12,Rpn5,PSMD12抗体 |
| Swissprot | O00232 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Fusion protein of human PSMD12 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:40-1:200; |
| Concentration | 0.72mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytosol,Extracellular region or secreted,extracellular exosome,extracellular region,Nucleus,nuclear proteasome complex,nucleoplasm,Other locations:cytoplasm,ficolin-1-rich granule lumen,membrane,proteasome accessory complex,proteasome complex,proteasome regulatory particle,proteasome regulatory particle, lid subcomplex,secretory granule lumen |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Images
Western blot analysis of Rat heart tissue lysate using PSMD12 Polyclonal Antibody at dilution of 1:300
Immunohistochemistry of paraffin-embedded Human lung cancer tissue using PSMD12 Polyclonal Antibody at dilution of 1:40(×200)
Immunohistochemistry of paraffin-embedded Human tonsil tissue using PSMD12 Polyclonal Antibody at dilution of 1:40(×200)
