Purified Anti-Human CD16 Antibody[3G8]
| 规格： | / 25μg / 100μg |
| 价格： | / ￥432 / ￥880 |
货号：E-AB-F1236A
货期：咨询
宿主: Mouse
反应性: H
应用: FCM
Overview
| Synonyms | Fc gamma receptor;Fc gamma receptor 3;FcγRIII |
| Swissprot | P08637,O75015 |
| Source | Mouse |
| Reactivity | Human |
| Immunogen | Recombinant Human CD16 protein |
| Application | FCM |
| Recommended dilution | FCM,,2 μg/mL(1×10^5-5×10^5 cells) |
| Concentration | 1mg/mL |
| Clonality | Monoclonal |
Properties
| Clone No | 3G8 |
|---|---|
| Isotype | Mouse IgG1, κ |
| Purification | >98%, Protein A/G purified |
| Conjugation | Unconjugated |
| Storage instructions | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Storage buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer. |
| Background | CD16 is a 60 kD highly glycosylated protein. It is a member of the Ig superfamily and is also known as B7-1, B7, and Ly-53. CD16 is constitutively expressed on dendritic cells and monocytes/macrophages, and inducibly expressed on activated B and T cells. The ligation of CD28 on T cells with CD16 and CD86 (B7-2) on antigen presenting cells (such as dendritic cells, macrophages, and B cells) elicits co-stimulation of T cells resulting in enhanced cell activation, proliferation, and cytokine production. CD16 appears to be expressed later in the immune response than CD86. CD16 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells. |
