Purified Anti-Human CD274/PD-L1 Antibody[29E.2A3]
| 规格： | / 25μg / 100μg |
| 价格： | / ￥345.6 / ￥640 |
货号：E-AB-F1133A
货期：咨询
宿主: Mouse
反应性: H
应用: FCM
Overview
| Synonyms | B7H1; PD-L1; PDCD1L1; PDCD1LG1; PDL1;B7 homolog 1;B7-H;B7-H1;Programmed cell death ligand 1 |
| Swissprot | Q9NZQ7 |
| Source | Mouse |
| Reactivity | Human |
| Immunogen | Recombinant Human PD-L1 protein |
| Application | FCM |
| Recommended dilution | FCM,,2 μg/mL(1×10^5-5×10^5 cells) |
| Concentration | 1mg/mL |
| Clonality | Monoclonal |
Properties
| Clone No | 29E.2A3 |
|---|---|
| Isotype | Mouse IgG2b, κ |
| Purification | >98%, Protein A/G purified |
| Conjugation | Unconjugated |
| Storage instructions | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Storage buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer. |
| Background | CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells. |
