RAB35 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-12236
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | GTP binding protein RAY,GTP-binding protein RAY,H ray,OTTHUMP00000240256,OTTHUMP00000240257,OTTHUMP00000240258,OTTHUMP00000240259,RAB1C,Rab35,RAB35 member RAS oncogene family,RAB35,member RAS oncogene family,RAB35,Ras related protein rab 1c (GTP binding protein ray),Ras related protein Rab 1C,Ras related protein Rab35,Ras-related protein Rab-1C,Ras-related protein Rab-35,RAY,RAB35抗体 |
| Swissprot | Q15286 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic peptide of human RAB35 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 0.4 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cell membrane. Membrane>clathrin-coated pit. Cytoplasmic vesicle>clathrin-coated vesicle. Endosome. Melanosome. Present on sorting endosomes and endosomal tubules. Tends to be enriched in PIP2-positive cell membrane domains. During mitosis, associated with the plasma membrane and present at the ingressing furrow during early cytokinesis as well as at the intercellular bridge later during cytokinesis. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes a small GTP-binding protein that belongs to the largest family within the Ras superfamily. Rab35 plays an important role in insulin-stimulated GLUT4 translocation in adipocytes.It is the target of TBC1D10A–C and that the intracellular accumulation of endosomal vesicles and impairs exosome secretion were occured when inhibition of Rab35 function.The surface of oligodendroglia in a GTP-dependent manner was localized Rab35, it increases the density of vesicles, and may have a function in docking or tethering. |
