RBBP8 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-11108
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | COM1,COM1,CtBP interacting protein,CtBP-interacting protein,CtIP,DNA endonuclease RBBP8,JWDS,RB binding protein 8 endonuclease,RBBP-8,RBBP8,Retinoblastoma-binding protein 8,Retinoblastoma-interacting protein and myosin-like,Rim,SAE2,SCKL2,Sporulation in the absence of SPO11 protein 2 homolog,RBBP8抗体 |
| Swissprot | Q99708 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein of human RBBP8 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:100-1:300 |
| Concentration | 0.7 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus. Chromosome. Associates with sites of DNA damage in S/G2 phase (PubMed:10764811). Ubiquitinated RBBP8 binds to chromatin following DNA damage (PubMed:16818604). |
| Tissue specificity | Expressed in ER-positive breast cancer lines, but tends to be down-regulated ER-negative cells (at protein level). |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. |
